Zobrazeno 1 - 10
of 72
pro vyhledávání: '"J L, Steimer"'
Autor:
S F, Marshall, R, Burghaus, V, Cosson, S Y A, Cheung, M, Chenel, O, DellaPasqua, N, Frey, B, Hamrén, L, Harnisch, F, Ivanow, T, Kerbusch, J, Lippert, P A, Milligan, S, Rohou, A, Staab, J L, Steimer, C, Tornøe, S A G, Visser
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
This document was developed to enable greater consistency in the practice, application, and documentation of Model‐Informed Drug Discovery and Development (MID3) across the pharmaceutical industry. A collection of “good practice” recommendation
Autor:
J L Steimer, Lewis B. Sheiner
Publikováno v:
Annual Review of Pharmacology and Toxicology. 40:67-95
We propose a framework for considering the role of pharmacokinetic/ pharmacodynamic modeling in drug development and an appraisal of its current and potential impact on that activity. After some introduction, definitions, and background information o
Publikováno v:
Biopharmaceutics & Drug Disposition. 11:279-309
The sublingual absorption of vincamine used as tracer occurs in two successive absorption steps: true sublingual absorption and absorption in the gastrointestinal tract of the drug dissolved in the saliva and not absorbed through the buccal mucosa. T
Publikováno v:
Journal of pharmacokinetics and pharmacodynamics. 29(1)
Capecitabine has been developed as an orally administered tumor selective fluoropyrimidine for use in the treatment of breast and colorectal cancer. The metabolic pathway for capecitabine includes 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fl
Autor:
J L Steimer, R Gieschke
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 25(1)
There is broad recognition within the pharmaceutical industry that the drug development process, especially the clinical part of it, needs considerable improvement to cope with rapid changes in research and health care environments. Modelling and sim
Publikováno v:
Pharmacokinetics of Drugs ISBN: 9783642786822
Variation in the response of individual patients to drugs is a matter of major concern in drug evaluation and therapy (Rowland et al. 1985). Since the seminal paper in 1972 (Sheiner et al. 1972), followed by its first application to digoxin 5 years l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9833cdc892b16385ac51346c183490fa
https://doi.org/10.1007/978-3-642-78680-8_15
https://doi.org/10.1007/978-3-642-78680-8_15
Publikováno v:
Journal of Pharmacokinetics & Pharmacodynamics; Feb2007, Vol. 34 Issue 1, p57-85, 29p
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 16:311-327
A new method, nonparametric maximum likelihood (NPML), for statistical analysis of population kinetic data is proposed. NPML provides a discrete estimate of the whole probability density function of the pharmacokinetic parameters. This permits a stra
Autor:
M. Claire, H. P. Gaeggeler, Bernard C. Rossier, Pierre Corvol, M. E. Oblin, J. L. Steimer, A. Venot
Publikováno v:
American Journal of Physiology-Cell Physiology. 248:C88-C101
The mechanism of aldosterone uptake in the epithelial cells of toad bladder was studied using mathematical modeling. Two complementary approaches were used. The first involved analysis of cytosolic aldosterone binding at steady state according to mod