Zobrazeno 1 - 9
of 9
pro vyhledávání: '"J L, Rideout"'
Autor:
G B, Roberts, J A, Fyfe, S A, McKee, S G, Rahim, S M, Daluge, M R, Almond, J L, Rideout, G W, Koszalka, T A, Krenitsky
Publikováno v:
Biochemical pharmacology. 46(12)
The varicella-zoster virus (VZV) thymidine kinase (TK) EC 2.7.2.21) catalyzes the phosphorylation of many anti-VZV nucleosides. Purified, bacterially expressed VZV TK was characterized with regard to N-terminal amino acid sequence, pI value, pH optim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d77f12a34fbb7920a7a9b86c2ec1d81
https://pubmed.ncbi.nlm.nih.gov/8274154
https://pubmed.ncbi.nlm.nih.gov/8274154
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 18(3)
A major metabolite of zidovudine (3'-azido-3'-deoxythymidine, AZT), which previously had not been observed in a variety of experimental animals, was identified in samples of plasma and urine from cynomolgus monkeys and a patient treated with AZT. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb027fd850ab7b50c7c3a713ce64322b
https://pubmed.ncbi.nlm.nih.gov/1974193
https://pubmed.ncbi.nlm.nih.gov/1974193
Publikováno v:
Journal of Medicinal Chemistry. 26:1489-1494
Ribonucleosides of 4-(alkylthio)-1H-pyrazolo[3,4-d]pyrimidines have been shown to be useful anticoccidial agents [Krenitsky, T. A.; Rideout, J. L.; Koszalka, G. W.; Inmon, R. B.; Chao, E. Y.; Elion, G. B.; Latter, V. S.; Williams, R. B. J. Med. Chem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e8670837e4c95e8dde193eb4631c63
https://doi.org/10.1021/jm00364a024
https://doi.org/10.1021/jm00364a024
Publikováno v:
Journal of Biological Chemistry. 251:6757-6766
2-Fluoroadenosine (F-Ado) is a potent inhibitor of lymphocyte-mediated cytolysis studied in vitro. The inhibition of cytolysis by F-Ado was potentiated markedly by an inhibiotr (Ro 20-1724) of adenosine 3':5'-monophosphate (cAMP) phosphodiesterase an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7d07f5dc612b72b5262857e80087e15
https://doi.org/10.1016/s0021-9258(17)33010-7
https://doi.org/10.1016/s0021-9258(17)33010-7
Publikováno v:
The Journal of biological chemistry. 251(21)
2-Fluoroadenosine (F-Ado) is a potent inhibitor of lymphocyte-mediated cytolysis studied in vitro. The inhibition of cytolysis by F-Ado was potentiated markedly by an inhibiotr (Ro 20-1724) of adenosine 3':5'-monophosphate (cAMP) phosphodiesterase an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb663accd6ef21141c707069e760e483
https://pubmed.ncbi.nlm.nih.gov/185217
https://pubmed.ncbi.nlm.nih.gov/185217
Publikováno v:
ChemInform. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82286005a1a8af551fa1f00713ef80d9
https://doi.org/10.1002/chin.198911191
https://doi.org/10.1002/chin.198911191
Autor:
T P, Zimmerman, G, Wolberg, G S, Duncan, J L, Rideout, L M, Beacham, T A, Krenitsky, G B, Elion
Publikováno v:
Biochemical pharmacology. 27(13)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0713392a9199de35326f8cd95b68d47c
https://pubmed.ncbi.nlm.nih.gov/213077
https://pubmed.ncbi.nlm.nih.gov/213077
Autor:
T A, Krenitsky, J V, Tuttle, G W, Koszalka, I S, Chen, L M, Beacham, J L, Rideout, G B, Elion
Publikováno v:
The Journal of biological chemistry. 251(13)
Kinetic constants were determined for 34 nucleoside substrates of deoxycytidine kinase (EC 2.7.1.74) from calf thymus. Substrate efficiency was assessed by the ratio of Vmax to Km. Inhibition constants were determined for 61 nonsubstrate nucleosides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bdacf5ad3f247f70ae09d7bc3818b912
https://pubmed.ncbi.nlm.nih.gov/932021
https://pubmed.ncbi.nlm.nih.gov/932021
Autor:
R L, Miller, D L, Adamczyk, W H, Miller, G W, Koszalka, J L, Rideout, L M, Beacham, E Y, Chao, J J, Haggerty, T A, Krenitsky, G B, Elion
Publikováno v:
The Journal of biological chemistry. 254(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9443a7a5b886c97d6f28a0c261ab0281
https://pubmed.ncbi.nlm.nih.gov/218934
https://pubmed.ncbi.nlm.nih.gov/218934