Zobrazeno 1 - 10 of 22 pro vyhledávání: '"J L, Occolowitz"'
1
Aqueous acidic degradation of the carbacephalosporin loracarbef
Autor: M J, Skibic, K W, Taylor, J L, Occolowitz, M W, Collins, J W, Paschal, L J, Lorenz, L A, Spangle, D E, Dorman, S W, Baertschi
Publikováno v: Journal of pharmaceutical sciences. 82(10)
The aqueous degradation of the carbacephalosporin loracarbef under moderately acidic conditions (pH range, 2.7-4.3) is described. Structures of a total of 10 compounds isolated by preparative reversed-phase HPLC have been proposed. Five of these 10 d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13a36da2c389591d1e79d3e653750ee5
https://pubmed.ncbi.nlm.nih.gov/8254485
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2
Disposition of zatosetron, a serotonin (5-HT3) receptor antagonist, in humans
Autor: P M, Franz, E L, Mattiuz, B L, Hatcher, K A, DeSante, A P, Breau, J L, Occolowitz, D E, Dorman, C R, Schmid, M J, Goldberg, A, Rubin
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 21(2)
Zatosetron is being tested clinically as an antianxiety agent; it is a highly selective antagonist of the serotonin 5-HT3 receptor, with minimal agonist activity. The disposition of [14C]zatosetron was studied in five healthy men after a single oral
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f8aa3c2219252f63efbad4c31cfab1a
https://pubmed.ncbi.nlm.nih.gov/8097693
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3
Structural biochemistry. IV. 3β-Hydroxy-17β-(l-prolyl)amino-androst-5-ene
Autor: George R. Pettit, Robert L. Smith, J. L. Occolowitz, A. K. Das Gupta
Publikováno v: Canadian Journal of Chemistry. 45:501-507
The synthesis of the title compound III was studied in detail and the following combination of methods was found reliable and convenient. The oxime derivative Ib of ketone la was reduced with sodium–ethanol to 3β-hydroxy-17β-amino-androst-5-ene.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9167252faf02747ed941af63ef9e23d
https://doi.org/10.1139/v67-085
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5
Energetics of the electron-impact fragmentation of alkoxybenzenes and alkylthiobenzenes
Autor: J. L. Occolowitz, G. J. Long, A. G. Moritz, R. G. Gillis
Publikováno v: Organic Mass Spectrometry. 1:527-530
Using energetic considerations, ketonic structures are postulated for the [Molefin]+ fragments derived from alkoxybenzenes, alkylthiobenzenes and 9-ethoxyanthracene. Experimentally determined heats of formation for the tautomeric molecular ions deriv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e225037628b33ac4a52ed9a5442a3c4c
https://doi.org/10.1002/oms.1210010405
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7
The ions [CH3S]+, [C2H5S]+ and [CH3O]+ formed by electron-impact
Autor: R. G. Gillis, D. Amos, J. L. Occolowitz, J. F. Pisani
Publikováno v: Organic Mass Spectrometry. 2:209-212
The mass spectra of deuterated species shows that both the isomeric ions (CH2=SH)(+) and (CH3-S)(+) are formed in the ratio 2:1 from CH3SH; the ions (CH3CH=SH)(+) and (CH3CH2S)(+) in the ratio 0.8:1 from CH3CH2SH; and (CH2=OH)(+) and (CH3-O)(+) in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9df3c36706ed1ff32d77b786ca1a1670
https://doi.org/10.1002/oms.1210020206
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10
Microbial transformation of A23187, a divalent cation ionophore antibiotic
Autor: J L Occolowitz, Bernard J. Abbott, D E Dorman, M Debono, L Farhner, D. S. Fukuda
A23187 is an ionophore antibiotic that forms dimeric complexes with divalent cations such an Mn2+ and Ca2+. Over 200 randomly selected soil microorganisms were incubated with A23187. None of these cultures was capable of transforming this compound. I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546b2de7622333df3c2e69614b60f3fe
https://europepmc.org/articles/PMC352958/
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