Zobrazeno 1 - 2
of 2
pro vyhledávání: '"J L, Myhre"'
Preclinical safety evaluation of the nadolol/bendroflumethiazide combination in mice, rats, and dogs
Autor:
A C, Stevens, C H, Keysser, J S, Kulesza, M M, Miller, J L, Myhre, P L, Sibley, Y H, Yoon, G R, Keim
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 4(3 Pt 1)
Nadolol, a beta-adrenergic antagonist, and bendroflumethiazide, a thiazide diuretic, were administered orally alone and in combination to animals in acute and 6-month toxicity studies and in a rat teratology study. The two drugs in combination showed
Autor:
J. L. Myhre, A. Depaoli
Publikováno v:
Stain technology. 60(2)
A method has been developed for the histologic evaluation of rat inner ear using glycol methacrylate (GMA) and steel knife sectioning. The necropsy, fixation, and histologic techniques described are not so complex and difficult as to preclude their r