Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J L, Merdink"'
Publikováno v:
Toxicology. 245:130-140
Chloral hydrate (CH) is a short-lived intermediate in the metabolism of trichloroethylene (TRI). TRI, CH, and two common metabolites, trichloroacetic acid (TCA) and dichloroacetic acid (DCA) have been shown to be hepatocarcinogenic in mice. To better
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fcea328e95e45f91557d42ea1569bd
https://doi.org/10.1016/j.tox.2007.12.018
https://doi.org/10.1016/j.tox.2007.12.018
Publikováno v:
Free Radical Biology and Medicine. 29:125-130
A key question in the risk assessment of trichloroethylene (TRI) is the extent to which its carcinogenic effects might depend on the formation of dichloroacetate (DCA) as a metabolite. One of the metabolic pathways proposed for the formation of DCA f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4244acba00055a57a9074da40e863cb
https://doi.org/10.1016/s0891-5849(00)00330-0
https://doi.org/10.1016/s0891-5849(00)00330-0
Publikováno v:
Toxicology and Applied Pharmacology. 158:103-114
Chloro, bromo, and mixed bromochloro haloacetates (HAs) are by-products of drinking water disinfection and are hepatocarcinogenic in rodents. We compared the toxicokinetics of a series of di-HAs, dichloro (DCA), bromochloro (BCA), dibromo (DBA) and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32297669b26ff3f2fbbe3ad66f246ff0
https://doi.org/10.1006/taap.1999.8698
https://doi.org/10.1006/taap.1999.8698
Publikováno v:
Risk Analysis. 18:261-269
Trichloroacetic acid (TCA) is a major metabolite of trichloroethylene (TRI) thought to contribute to its hepatocarcinogenic effects in mice. Recent studies have shown that peak blood concentrations of TCA in rats do not occur until approximately 12 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa97b05677a8ed9e28a9f0770e20b66
https://doi.org/10.1111/j.1539-6924.1998.tb01293.x
https://doi.org/10.1111/j.1539-6924.1998.tb01293.x
Publikováno v:
Toxicological Sciences. 45:33-41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff8fbbba2fb2dcd0bdcb6a56a0adc28d
https://doi.org/10.1093/toxsci/45.1.33
https://doi.org/10.1093/toxsci/45.1.33
Publikováno v:
Journal of Steroid Biochemistry. 36:659-666
Fluoxymesterone, an anabolic steroid, is metabolized in man primarily by 6 beta-hydroxylation, 4-ene-reduction, 3-keto-reduction, and 11-hydroxy-oxidation. These pathways of metabolism are suggested by the positive identification of 4 metabolites and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f386acfaf6162feb7d459b16bf9771c
https://doi.org/10.1016/0022-4731(90)90185-u
https://doi.org/10.1016/0022-4731(90)90185-u
Publikováno v:
Toxicology. 173(3)
Dichloroacetate (DCA) is a rodent carcinogen commonly found in municipal drinking water supplies. Toxicokinetic studies have established that elimination of DCA is controlled by liver metabolism, which occurs by the cytosolic enzyme glutathione-S-tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb3f0cbf7509e63897f27b5b290d169
https://pubmed.ncbi.nlm.nih.gov/11960676
https://pubmed.ncbi.nlm.nih.gov/11960676
Publikováno v:
Journal of applied toxicology : JAT. 21(1)
The oral and i.v. elimination kinetics were investigated for bromodichloroacetate (BDCA), a haloacetate found in drinking water. The BDCA was administered at a dose of 5, 20 and 100 mg kg(-1) to B6C3F1 mice and appears to distribute to the total body
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb33e993d656b0ff702b0f9f69f8ba4
https://pubmed.ncbi.nlm.nih.gov/11180280
https://pubmed.ncbi.nlm.nih.gov/11180280
Publikováno v:
Chemico-biological interactions. 123(3)
Dichloroacetate (DCA) and trichloroacetate (TCA) are prominent by-products of chlorination of drinking water. Both chemicals have been shown to be hepatic carcinogens in mice. Prior work has demonstrated that DCA inhibits its own metabolism in rats a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefb93b2d451977f3c5a5d036864443b
https://pubmed.ncbi.nlm.nih.gov/10654841
https://pubmed.ncbi.nlm.nih.gov/10654841
Publikováno v:
Journal of toxicology and environmental health. Part A. 57(5)
Chloral hydrate (CH) is a commonly found disinfection by-product in water purification, a metabolite of trichloroethylene, and a sedative/hypnotic drug. CH and two of its reported metabolites, trichloroacetic acid (TCA) and dichloroacetic acid (DCA),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b973f46ea27bf6748e15f94758e64ef5
https://pubmed.ncbi.nlm.nih.gov/10405189
https://pubmed.ncbi.nlm.nih.gov/10405189