Zobrazeno 1 - 10
of 41
pro vyhledávání: '"J L, Meinkoth"'
Publikováno v:
Journal of Virology. 70:2350-2359
The human immunodeficiency virus type 1 Rev trans activator binds directly to unspliced viral mRNA in the nucleus and activates its transport to the cytoplasm. In additon to the sequences that confer RNA binding and nuclear localization, Rev has a ca
Publikováno v:
Endocrinology. 137:96-104
We previously reported that microinjection of purified Ras protein stimulated DNA synthesis in quiescent Wistar rat thyrocytes and that TSH (TSH)-stimulated DNA synthesis was Ras-dependent. In contrast to these results, microinjection of cellular or
Publikováno v:
The FASEB Journal. 9:552-558
Nitric oxide (NO) increases cytosolic guanylate cyclase activity and thereby activates the cGMP signal transduction pathway. The cAMP and Ca2+/phospholipid signal transduction pathways activate transcription factors that bind to the cAMP response ele
Publikováno v:
Molecular and Cellular Biology. 15:1826-1832
Cyclic AMP (cAMP) stimulates the expression of numerous genes through the protein kinase A (PK-A)-mediated phosphorylation of the nuclear factor CREB at Ser-133 (G. A. Gonzalez and M. R. Montminy, Cell 59:675-680, 1989). Like other signal transductio
Autor:
J L Meinkoth, Susan S. Taylor, Stephen R. Adams, Alec Tate Harootunian, Wei Wen, Roger Y. Tsien, James R. Feramisco
Publikováno v:
Journal of Biological Chemistry. 269:32214-32220
The heat-stable inhibitor of cAMP-dependent protein kinase (PKI) was shown previously to export the kinase catalytic subunit (C) from the nucleus (Fantozzi, D. A., Harootunian, A. T., Wen, W., Taylor, S. S., Feramisco, J.R., Tsien, R. Y., and Meinkot
Autor:
J L Meinkoth, Susan S. Taylor, Vincent M. Coghlan, Rigmor Solberg, Wei Wen, Kjetil Taskén, Tore Jahnsen, John D. Scott
Publikováno v:
Experimental Cell Research. 214:595-605
The human regulatory subunit RI beta of cAMP-dependent protein kinases was expressed in Escherichia coli as a fusion protein with glutathione S-transferase. Purification was performed by affinity chromatography on glutathione-agarose beads after clea
Autor:
Marilyn G. Farquhar, J L Meinkoth, C Nuoffer, Bridget S. Wilson, James R. Feramisco, William E. Balch, M McCaffery
Publikováno v:
The Journal of Cell Biology
The Golgi apparatus is a dynamic organelle whose structure is sensitive to vesicular traffic and to cell cycle control. We have examined the potential role for rab1a, a GTPase previously associated with ER to Golgi and intra-Golgi transport, in the f
Publikováno v:
Journal of Biological Chemistry. 269:5699-5704
We have investigated the role of cellular p21ras protein in insulin and insulin-like growth factor-I (IGF-I) signaling pathways. Insulin stimulation increased Ras-GTP formation in Rat-1 fibroblasts overexpressing normal human insulin receptors (HIRc-
Autor:
J L Meinkoth, Susan S. Taylor, James R. Feramisco, D. A. Fantozzi, Roger Y. Tsien, Wei Wen, Alec Tate Harootunian
Publikováno v:
Journal of Biological Chemistry. 269:2676-2686
The catalytic (C) subunit of cAMP-dependent protein kinase is inhibited by the regulatory (R) subunit and by a thermostable inhibitor (PKI). Both inhibitors also affect the intracellular distribution of the C subunit. Whether injected into the cytopl