Výsledky vyhledávání - "J L, Jameson"

Estrogen Receptor α Signaling Pathways Differentially Regulate Gonadotropin Subunit Gene Expression and Serum Follicle-Stimulating Hormone in the Female Mouse

Autor: Jeffrey Weiss, J. E. Levine, J L Jameson, Lisa A. Hurley, Christine Glidewell-Kenney

Publikováno v: Endocrinology. 149:4168-4176

Estrogen, acting via estrogen receptor (ER)alpha, regulates serum gonadotropin levels and pituitary gonadotropin subunit expression. However, the cellular pathways mediating this regulation are unknown. ERalpha signals through classical estrogen resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d549e2e4f428da10622dff9e4759359
https://doi.org/10.1210/en.2007-1807

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Human disorders caused by nuclear receptor gene mutations

Autor: John C. Achermann, J L Jameson

Publikováno v: Pure and Applied Chemistry. 75:1785-1796

The identification of naturally occurring nuclear receptor mutations highlights the critical role that many of these transcription factors play in human endocrine development and function. Inactivating mutations in the ligand-dependent nuclear recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ecf80d1e1b46b19a7fbb966b7efb84a
https://doi.org/10.1351/pac200375111785

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Missense Mutations Cluster within the Carboxyl-Terminal Region of DAX-1 and Impair Transcriptional Repression1

Autor: John C. Achermann, Songya Pang, A Rosler, M Ito, J L Jameson, Bernard L. Silverman, Reema L. Habiby

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 86:3171-3175

DAX-1 is an orphan nuclear receptor that plays a key role in the development and function of the adrenal gland and hypothalamic-pituitary gonadal axis. Mutations in the gene encoding DAX-1 result in X-linked adrenal hypoplasia congenita (AHC). Affect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25ecd5d7b74a75fe7c2fd34ca68cbe57
https://doi.org/10.1210/jcem.86.7.7660

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X-Linked Adrenal Hypoplasia Congenita and DAX-1

Autor: Joshua J. Meeks, John C. Achermann, J L Jameson

Publikováno v: The Endocrinologist. 10:289-299

X-linked adrenal hypoplasia congenita (AHC) (OMIM, 300200) is a potentially life-threatening condition that results from mutations in the orphan nuclear receptor, DAX-1. More than 50 different mutations in the DAX1 gene have been reported. DAX1 is ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab6014300b4968fea2e91664b631f811
https://doi.org/10.1097/00019616-200010050-00003

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Role of Ets2 in cyclic AMP regulation of the human chorionic gonadotropin Î² promoter

Autor: W Johnson, J L Jameson

Publikováno v: Molecular and Cellular Endocrinology. 165:17-24

Activation of the human chorionic gonadotropin beta (hCGbeta) by the protein kinase A (PKA) pathway has been shown to occur through an activating protein-2 (AP-2)-dependent mechanism. However, in HepG2 cells, which are deficient in AP-2, the PKA cata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66fd4e358b93c3a38b5e171066eff7d
https://doi.org/10.1016/s0303-7207(00)00269-0

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X-Linked Adrenal Hypoplasia Congenita: A Mutation inDAX1Expands the Phenotypic Spectrum in Males and Females1

Autor: Stephanie B. Seminara, William F. Crowley, J L Jameson, Myron Genel, John C. Achermann

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 84:4501-4509

X-linked adrenal hypoplasia congenita (AHC) is a disorder associated with primary adrenal insufficiency and hypogonadotropic hypogonadism (HH). The gene responsible for X-linked AHC, DAX1, encodes a member of the nuclear hormone receptor superfamily.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a63e80fb6a03b1389e269f344d29b89
https://doi.org/10.1210/jcem.84.12.6172

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Mutational Analysis of DAX1 in Patients with Hypogonadotropic Hypogonadism or Pubertal Delay1

Autor: Tom Kotlar, Wen-Xia Gu, William F. Crowley, Layman Lc, Richard J. Sherins, Stephanie B. Seminara, David Bick, Sabacan Lp, John C. Achermann, Joshua J. Meeks, J L Jameson, Reema L. Habiby, Peter C. Hindmarsh

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 84:4497-4500

Although delayed puberty is relatively common and often familial, its molecular and pathophysiologic basis is poorly understood. In contrast, the molecular mechanisms underlying some forms of hypogonadotropic hypogonadism (HH) are clearer, following

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99e4d6ee14dcd092958974796a5bb926
https://doi.org/10.1210/jcem.84.12.6269

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Estradiol Increases Proliferation and Down-Regulates the Sodium/Iodide Symporter Gene in FRTL-5 Cells1

Autor: Tania Weber Furlanetto, J L Jameson, Lynda Q. Nguyen

Publikováno v: Endocrinology. 140:5705-5711

Goiter (increased thyroid gland size) is more prevalent in women than men, even in areas where iodine levels in the diet are sufficient. We investigated a possible role of estrogen on thyroid follicular cell growth using rat FRTL-5 thyroid follicular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4623b417389d2bc2f1e0b15770f6624d
https://doi.org/10.1210/endo.140.12.7197

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AP-2 (Activating Protein 2) and Sp1 (Selective Promoter Factor 1) Regulatory Elements Play Distinct Roles in the Control of Basal Activity and Cyclic Adenosine 3′,5′-Monophosphate Responsiveness of the Human Chorionic Gonadotropin-β Promoter

Autor: W Johnson, J L Jameson

Publikováno v: Molecular Endocrinology. 13:1963-1975

The CG beta-subunit gene (CGbeta) arose evolutionarily from the LH beta-subunit gene (LHbeta) through gene duplication. Although the promoter sequences of the CGbeta and human (h) hLHbeta genes are greater than 90% homologous, their expression patter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fccc84a3b6a9e94e1e37d89cf89463
https://doi.org/10.1210/mend.13.11.0386

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Estradiol Suppresses Phosphorylation of Cyclic Adenosine 3′,5′-Monophosphate Response Element Binding Protein (CREB) in the Pituitary: Evidence for Indirect Action via Gonadotropin-Releasing Hormone

Autor: J L Jameson, J L Shin, W R Duan

Publikováno v: Scopus-Elsevier

Estradiol acts on the hypothalamus and pituitary gland to modulate the synthesis and secretion of gonadotropins. We recently reported that GnRH-induced transcription of the human gonadotropin α-gene promoter is increased markedly in transfected pitu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18383a4a41d58c23bbe0e7ad9b888679
https://doi.org/10.1210/mend.13.8.0322

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