Zobrazeno 1 - 10
of 59
pro vyhledávání: '"J L, Fischel"'
Autor:
H. Marouani, J. L. Fischel, P. Formento, N. Renée, M. Chefrour, G. Milano, C. Mercier, Mireille Francoual, J. Ciccolini, R.-M. Ferri-Dessens, S. Giacometti
Publikováno v:
Journal of Chemotherapy. 22:129-133
The combination of capecitabine and the tyrosine kinase inhibitor erlotinib has recently been tested in patients with gemcitabine-refractory pancreatic tumors, with limited success. To understand this lack of efficacy, we studied the molecular effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58934f638da133250e7a5d1ee81b9a9a
https://doi.org/10.1179/joc.2010.22.2.129
https://doi.org/10.1179/joc.2010.22.2.129
Publikováno v:
Oncologie. 11:152-159
Le developpement des therapeutiques moleculaires ciblees en cancerologie est, aujourd’hui, en plein essor et fait appel a deux grandes categories de molecules, les anticorps monoclonaux (Acm) et les inhibiteurs de tyrosine-kinase (TKI). L’action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67b91b098ee85c45df520bffa365d865
https://doi.org/10.1007/s10269-008-1038-5
https://doi.org/10.1007/s10269-008-1038-5
Autor:
Frederic Peyrade, G. Milano, Alexandre Bozec, Olivier Dassonville, J.-L. Fischel, Gilles Poissonnet
Publikováno v:
Oncologie. 8:842-849
Le developpement de therapeutiques ciblees en cancerologie est actuellement en plein essor et fait appel essentiellement a deux grandes categories de molecules, les anticorps monoclonaux (Mabs) et les inhibiteurs de tyrosine kinase (TKIs). Parmi ces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05f7fbd19bb36f9ed1f283c340eeb7ee
https://doi.org/10.1007/s10269-006-0522-z
https://doi.org/10.1007/s10269-006-0522-z
Autor:
Marie-Christine Etienne, Mireille Francoual, Moïse Namer, Eric Francois, Jean-Louis Formento, Marc Frenay, Gérard Milano, P. Formento, J. L. Fischel
Publikováno v:
Breast Cancer Research and Treatment. 17:211-219
Epidermal growth factor (EGF) is a 6000 kDa peptide which exerts its biological effects by binding to a specific cell membrane receptor (EGF-R). Extensive studies on EGF-R in breast tumors have demonstrated the prognostic value of such assays. EGF-R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a567a5bb868b1ef738a0c810c3078f
https://doi.org/10.1007/bf01806370
https://doi.org/10.1007/bf01806370
Publikováno v:
Cancer research. 61(21)
The transcription factor nuclear factor (NF) kappaB is involved in the regulation of cell survival. NFkappaB is activated in many malignant tumors and seems to play a role in the resistance to cytostatic treatments and escape from apoptosis. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3aaefdc51948a2891949de8e079ab289
https://pubmed.ncbi.nlm.nih.gov/11691793
https://pubmed.ncbi.nlm.nih.gov/11691793
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(10)
The combination of oxaliplatin (LOHP)-5-fluorouracil (FU)-folinic acid (FA) has provided high response rates in pretreated patients with advanced colorectal cancer that is resistant to FU-FA. However, the choice of the optimal schedule between LOHP,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87fa82d7b30930020b668319a823af14
https://pubmed.ncbi.nlm.nih.gov/9796987
https://pubmed.ncbi.nlm.nih.gov/9796987
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 1(9)
Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme of 5-fluorouracil (FU) catabolism. Ethynyluracil (776C) is a very potent, mechanism-based irreversible DPD inhibitor that improves the antitumor efficacy and the therapeutic index of F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4780a5d36c69c5299e7f2c227a231dc8
https://pubmed.ncbi.nlm.nih.gov/9816071
https://pubmed.ncbi.nlm.nih.gov/9816071
Autor:
J L, Fischel, R, Lemee, P, Formento, C, Caldani, J L, Moll, D, Pesando, A, Meinesz, P, Grelier, P, Pietra, A, Guerriero
Publikováno v:
Anticancer research. 15(5B)
Caulerpa taxifolia (Vahl) C. Agardh (Ulvophyceae, Caulerpales) is an algae of tropical origin that was accidentally introduced into the Mediterranean in 1984. Caulerpenyne (Cau) is the major metabolite present in Caulerpa taxifolia. This metabolite h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c18d3e8e09486295438f108f4e237e7
https://pubmed.ncbi.nlm.nih.gov/8572617
https://pubmed.ncbi.nlm.nih.gov/8572617
Autor:
J. L. Fischel, Antoine Thyss, Olivier Dassonville, F Demard, Patricia Formento, M Schneider, S. Chéradame, Gérard Milano, Marie-Christine Etienne, Nicole Renée
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 13(7)
PURPOSE The aim of the present study was to analyze the role of thymidylate synthase (TS; main cellular target of fluorouracil [FU]) and dihydropyrimidine dehydrogenase (DPD; rate-limiting enzyme of FU catabolism) in tumoral biopsies with respect to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b6a4e9b137da03079a5dfd4554996e
https://pubmed.ncbi.nlm.nih.gov/7602356
https://pubmed.ncbi.nlm.nih.gov/7602356
Publikováno v:
Bulletin du cancer. 81(7)
Fotemustine (Fote) is a new aminoacid linked chloroethyl nitrosourea which has been shown to be useful in disseminated malignant melanoma. The aim of the present study was to analyze the cytotoxic effects resulting from the combination of antiestroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65c483a7f09cd96139bdd3d22b1a826a
https://pubmed.ncbi.nlm.nih.gov/7742602
https://pubmed.ncbi.nlm.nih.gov/7742602