Zobrazeno 1 - 10 of 40 pro vyhledávání: '"J L, Falk"'
2
Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner
Autor: M. S. Lee, Sue Atherton-Fessler, Laura L. Parker, K. I. Swenson, Helen Piwnica-Worms, S. Ogg, J. L. Falk
Publikováno v: The EMBO Journal. 10:1255-1263
The regulation of p34cdc2 was investigated by overproducing p34cdc2, cyclin (A and B) and the wee1+ gene product (p107wee1) using a baculoviral expression system. p34cdc2 formed a functional complex with both cyclins as judged by co-precipitation, ph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47768004b083901447d7ea2be89138f9
https://doi.org/10.1002/j.1460-2075.1991.tb08067.x
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3
Oral cocaine pharmacokinetics and pharmacodynamics in a cumulative-dose regimen: pharmacokinetic-pharmacodynamic modeling of concurrent operant and spontaneous behavior within an operant context
Autor: C E, Lau, L, Sun, Q, Wang, A, Simpao, J L, Falk
Publikováno v: The Journal of pharmacology and experimental therapeutics. 295(2)
Despite wide use of cumulative-dosing procedures to evaluate dose-response relations, limited attention has been paid to investigating drug concentration-effect relations. We first characterized the pharmacokinetic (PK) parameters for i.v. (2 mg/kg)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e008c40eaea99014e6d7d4e4a6e57277
https://pubmed.ncbi.nlm.nih.gov/11046099
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4
Within-subject variability in cocaine pharmacokinetics and pharmacodynamics after intraperitoneal compared with intravenous cocaine administration
Autor: F, Ma, J L, Falk, C E, Lau
Publikováno v: Experimental and clinical psychopharmacology. 7(1)
Performance in rats (Rattus norvegicus) was measured on a differential reinforcement of low-rate schedule (DRL 45-s) in 1.5-hr sessions after 2 mg/kg intravenous (i.v.) or 10-20 mg/kg intraperitoneal (i.p.) cocaine administration, with each dose give
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ef1e72fccb0cb0a7701626de72d0f69
https://pubmed.ncbi.nlm.nih.gov/10036604
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5
Pharmacokinetic-pharmacodynamic modeling of the psychomotor stimulant effect of cocaine after intravenous administration: timing performance deficits
Autor: C E, Lau, F, Ma, D M, Foster, J L, Falk
Publikováno v: The Journal of pharmacology and experimental therapeutics. 288(2)
We investigated dose-response cocaine pharmacokinetic and metabolite profiles in a within-subject design after intravenous bolus cocaine administration (1-4 mg/kg) in rats under a food-limited regimen. Cocaine was rapidly distributed (T1/2beta = 1.09
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8461f1e6e9b4e30e98d56a6893b6ffdb
https://pubmed.ncbi.nlm.nih.gov/9918556
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9
Differential reinforcement of low rate performance, pharmacokinetics and pharmacokinetic-pharmacodynamic modeling: independent interaction of alprazolam and caffeine
Autor: C E, Lau, Y, Wang, J L, Falk
Publikováno v: The Journal of pharmacology and experimental therapeutics. 281(3)
To investigate the interaction between alprazolam and caffeine, performance on a differential reinforcement of low-rate behavior schedule and the respective pharmacokinetics (PK) were explored in concurrent studies. Alprazolam PK was not altered by c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c05086ef0ed5e10ee8256ee4b514bf34
https://pubmed.ncbi.nlm.nih.gov/9190832
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10
Tolerance to the anxiolytic effects of the triazolobenzodiazepines triazolam and alprazolam, as measured by the ingestion of a hypertonic sodium chloride solution in rats
Autor: E J, Barbarito, C E, Lau, J L, Falk
Publikováno v: The Journal of pharmacology and experimental therapeutics. 278(3)
Rats were adapted to a water-deprivation regimen that allowed daily 1-hr drinking sessions of a single fluid, either 1.5% NaCl solution or water. Oral, presession, acute doses of triazolam (0.05-1.6 mg/kg) or alprazolam (0.4-6.4 mg/kg) produced dose-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e88dea26013a0d906dc7d71c1aa307dc
https://pubmed.ncbi.nlm.nih.gov/8819503
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