Zobrazeno 1 - 10
of 72
pro vyhledávání: '"J L, Claflin"'
Publikováno v:
The Journal of Immunology. 153:3594-3602
To study the distribution of somatic mutations in the DNA flanking the 5' side of rearranged Ig V genes, the 5' region of 14 to 21 mutant forms of three different V(D)J were sequenced. These were compared with a fourth V(D)J for which the flanking se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70309be4f4e20e0ab2e8acf2e88974ee
https://doi.org/10.4049/jimmunol.153.8.3594
https://doi.org/10.4049/jimmunol.153.8.3594
Publikováno v:
The Journal of Immunology. 151:5955-5965
We have initiated a series of experiments to explore the effect of changes in density of the surface Ig receptor (mIg) on Ag:mIg interactions. We transfected into the surface Ig-negative B cell line M12.4 H and L chain constructs known to effect a 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1feeea350bde46dcbc5a544da297ada2
https://doi.org/10.4049/jimmunol.151.11.5955
https://doi.org/10.4049/jimmunol.151.11.5955
Publikováno v:
The Journal of Immunology. 146:3652-3655
Somatic hypermutation is known to occur in the VJ kappa exon and its flanking sequences, yet little is known about the hypermutation mechanism or its exact target within the rearranged locus. Mutations may occur at the same frequency, spanning a regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58a469ab536b4b07659e481e0556a54d
https://doi.org/10.4049/jimmunol.146.10.3652
https://doi.org/10.4049/jimmunol.146.10.3652
Publikováno v:
The Journal of Immunology. 146:3218-3226
Somatic hypermutation of the Ig genes occurs in rearranged V(D)J and its flanking sequences after Ag stimulation. Even though C regions and unrearranged V segments have been found to lack mutations, it is not known whether the mutational mechanism ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3592c575c6835552bb79eeca28ed7e52
https://doi.org/10.4049/jimmunol.146.9.3218
https://doi.org/10.4049/jimmunol.146.9.3218
Autor:
C Schultz, J Petrini, J Collins, J L Claflin, K A Denis, P Gearhart, C Gritzmacher, T Manser, M Shulman, W Dunnick
Publikováno v:
The Journal of Immunology. 144:363-370
We have analyzed the configuration of the H chain locus of 41 hybridomas by Southern blot analysis. Each H chain switch region was determined to be germ line, rearranged, or deleted. Including 13 previously analyzed hybridomas, 60% of those with rear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c42869f748af34a8081a223674b099ea
https://doi.org/10.4049/jimmunol.144.1.363
https://doi.org/10.4049/jimmunol.144.1.363
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 153(8)
To study the distribution of somatic mutations in the DNA flanking the 5' side of rearranged Ig V genes, the 5' region of 14 to 21 mutant forms of three different V(D)J were sequenced. These were compared with a fourth V(D)J for which the flanking se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05f4b9d573b588226afd545a824519b9
https://pubmed.ncbi.nlm.nih.gov/7930582
https://pubmed.ncbi.nlm.nih.gov/7930582
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 151(11)
We have initiated a series of experiments to explore the effect of changes in density of the surface Ig receptor (mIg) on Ag:mIg interactions. We transfected into the surface Ig-negative B cell line M12.4 H and L chain constructs known to effect a 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::61904c396147b183dd9955bb6df55226
https://pubmed.ncbi.nlm.nih.gov/8245440
https://pubmed.ncbi.nlm.nih.gov/8245440
Publikováno v:
Current topics in microbiology and immunology. 182
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::835ef1b5e83287354e00005b478ab5e8
https://pubmed.ncbi.nlm.nih.gov/1490349
https://pubmed.ncbi.nlm.nih.gov/1490349
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783642776359
The Immunoglobulin heavy chain switch, in which a variable region gene is rearranged from association with the Cμ gene to association with a C7, Ce, or Cα gene, is mediated by a recombination event between switch (S) regions [reviewed in 1]. Switch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9f46ce940301dccd16654c5c55c4c4b
https://doi.org/10.1007/978-3-642-77633-5_17
https://doi.org/10.1007/978-3-642-77633-5_17
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 146(10)
Somatic hypermutation is known to occur in the VJ kappa exon and its flanking sequences, yet little is known about the hypermutation mechanism or its exact target within the rearranged locus. Mutations may occur at the same frequency, spanning a regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07480e35ccb8e1db1dd4a708377f0eae
https://pubmed.ncbi.nlm.nih.gov/1902859
https://pubmed.ncbi.nlm.nih.gov/1902859