Zobrazeno 1 - 10
of 59
pro vyhledávání: '"J Kurt Chuprun"'
Autor:
Jessica I Gold, Jeffrey S Martini, Jonathan Hullmann, Erhe Gao, J Kurt Chuprun, Linda Lee, Douglas G Tilley, Joseph E Rabinowitz, Julie Bossuyt, Donald M Bers, Walter J Koch
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57324 (2013)
G protein-Coupled Receptors (GPCRs) kinases (GRKs) play a crucial role in regulating cardiac hypertrophy. Recent data from our lab has shown that, following ventricular pressure overload, GRK5, a primary cardiac GRK, facilitates maladaptive myocyte g
Externí odkaz:
https://doaj.org/article/f933052fcc7e42b0bf320c5f5af94e73
Autor:
Qian Fan, Zheng M Huang, Matthieu Boucher, Xiying Shang, Lin Zuo, Henriette Brinks, Wayne Bond Lau, Jianke Zhang, J Kurt Chuprun, Erhe Gao
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73537 (2013)
As technological interventions treating acute myocardial infarction (MI) improve, post-ischemic heart failure increasingly threatens patient health. The aim of the current study was to test whether FADD could be a potential target of gene therapy in
Externí odkaz:
https://doaj.org/article/27ed734ee9b24f058525a0b192b4dc4e
Autor:
Xuefei Zhao, Matthew Cooper, James V. Michael, Yanki Yarman, Aiden Baltz, J. Kurt Chuprun, Walter J. Koch, Steven E. McKenzie, Maurizio Tomaiuolo, Timothy J. Stalker, Li Zhu, Peisong Ma
Publikováno v:
Blood Advances. 6:4524-4536
The critical role of G protein–coupled receptor kinase 2 (GRK2) in regulating cardiac function has been well documented for >3 decades. Targeting GRK2 has therefore been extensively studied as a novel approach to treating cardiovascular disease. Ho
Publikováno v:
Cells, Vol 10, Iss 5, p 1211 (2021)
When myocardial function is compromised as in heart failure (HF), there is activation of the sympathetic nervous system with elevated circulating catecholamine levels. These catecholamines activate cardiac and extra-cardiac adrenergic receptors (ARs)
Externí odkaz:
https://doaj.org/article/f0cb5042380a4930886f2361f9f3052d
Autor:
Jessica Pfleger, Kamila Bledzka, Iyad H. Manaserh, Jessica Grondolsky, Sarah M. Schumacher, Erhe Gao, Walter J. Koch, Rajika Roy, J. Kurt Chuprun
Publikováno v:
J Mol Cell Cardiol
G protein-coupled receptor (GPCR) kinase 2 (GRK2) expression and activity are elevated early on in response to several forms of cardiovascular stress and are a hallmark of heart failure. Interestingly, though, in addition to its well-characterized ro
Autor:
Anna-Maria Lucchese, Walter J. Koch, Kenneth S. Gresham, Eric W. Barr, Rajika Roy, Akito Eguchi, J. Kurt Chuprun, Melissa Lieu, Amanda M. Peluzzo, Jessica Ibetti, Ryan C. Coleman
Publikováno v:
Sci Signal
Aberrant changes in gene expression underlie the pathogenesis and progression of pressure-overload heart failure, leading to maladaptive cardiac hypertrophy, ventricular remodeling, and contractile dysfunction. Signaling through the G protein Gq trig
Autor:
Mohsin Khan, Erhe Gao, Jin-Sook Kwon, Jessica Ibetti, Rajika Roy, J. Kurt Chuprun, Raj Kishore, Walter J. Koch, Sarah M. Schumacher
Publikováno v:
Am J Physiol Heart Circ Physiol
Recent data supporting any benefit of stem cell therapy for ischemic heart disease have suggested paracrine-based mechanisms via extracellular vesicles (EVs) including exosomes. We have previously engineered cardiac-derived progenitor cells (CDCs) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac1ea6d08744929def5a98327fc1151
https://europepmc.org/articles/PMC8260382/
https://europepmc.org/articles/PMC8260382/
Autor:
Ryan C. Coleman, Kenneth S. Gresham, Jessica Ibetti, Erhe Gao, J. Kurt Chuprun, Akito Eguchi, Walter J. Koch
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Pathological remodeling of the heart is a hallmark of chronic heart failure (HF) and these structural changes further perpetuate the disease. G protein-coupled receptor (GPCR) kinase 5 (GRK5) has been shown to cause deleterious effects o
Publikováno v:
Circulation Research. 127
Background and Purpose: The influence of β-adrenoceptor (βAR) signaling on the regulation of exosomes secreted from cardiomyocytes is unknown and since catecholamines are increased in heart failure (HF), there is interest in uncovering whether βAR
Autor:
J. Kurt Chuprun, Mesele-Christina Valenti, Jessica Pfleger, Konstantinos Drosatos, Kenneth S. Gresham, Benjamin P. Woodall, Meryl A. Woodall, Walter J. Koch, Alessandro Cannavo
Publikováno v:
JCI insight. 5
A vast body of literature has established G protein–coupled receptor kinase 2 (GRK2; family: β-adrenergic receptor kinases [βARKs]) as a key player in the development and progression of heart failure. Inhibition of GRK2 improves cardiac function