Zobrazeno 1 - 10
of 99
pro vyhledávání: '"J Klominek"'
Publikováno v:
Scandinavian Journal of Immunology. 69:381-386
Asthma is characterized by eosinophilic inflammation and remodelling of the airways. Eosinophil cationic protein (ECP) is a protein released by activated eosinophils and the hypothesis that ECP contributes to the development of structural changes in
Publikováno v:
European Respiratory Journal. 14:405-411
Signalling through epidermal growth factor (EGF) receptor leads to several cellular responses including cell division and cell migration. Since EGF receptors are expressed on normal mesothelial cells, this study investigated whether EGF receptor liga
Publikováno v:
European Respiratory Journal. 11:400-407
Since tumour progression is dependent on the ability of malignant cells to interact with the extracellular matrix (ECM), we have investigated the significance of beta1 and beta3 integrins for migration of lung cancer cells to components of the ECM. I
Publikováno v:
The Journal of Immunology. 158:76-84
The mechanisms by which T lymphocytes are transformed from passively transported cells during circulation in the vascular system to actively migrating cells during extravasation are unknown. Therefore, the possibility that lymphocyte receptors are ca
Publikováno v:
The Journal of Immunology. 153:960-971
We have investigated the role of alpha 4 beta 1 and alpha 5 beta 1 integrins in adhesion and migration of T lymphocytes to extracellular matrix proteins. Fibronectin, collagen type IV, and laminin promoted haptotactic and chemotactic migration of lym
Publikováno v:
Lung Cancer. 6:16-27
Malignant mesotheliomas often constitute a difficult diagnostic problem. A possible marker for a mesenchymal origin of the tumor is the type of collagen produced. A study was therefore made of the immunocytochemical reactivity of collagen type I, as
Red blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 290(2)
Tissue remodeling is an important process in many inflammatory and fibrotic lung disorders. RBC may in these conditions interact with extracellular matrix (ECM). Fibroblasts can produce and secrete matrix components, matrix-degrading enzymes (MMPs) a
Regulation of matrix metalloprotease activity in malignant mesothelioma cell lines by growth factors
Autor:
J Klominek, Z Liu
Background: The extracellular matrix metalloproteases (MMPs) produced by tumour and stromal cells are believed to play a key role in tumour cell invasion and metastasis. Malignant mesothelioma is a highly aggressive tumour. Previous studies have show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9425353cb56d4e828b932a699dd297
https://europepmc.org/articles/PMC1746590/
https://europepmc.org/articles/PMC1746590/
Publikováno v:
Anticancer research. 20(4)
Activated CD 3+ enriched human peripheral blood T cells exhibited potent capacity for transendothelial migration through HUVEC layers in the absence of T cell ***. In contrast, malignant human T cell lines *** no or negligible ability of transendothe
Publikováno v:
Anticancer research. 19(3A)
Human T cells produce and release fibronectin degrading neutral serine proteases with a molecular weight of 50 kD, 70-80 kD (doublet) and 95 kD and have a cell associated 400 kD fibronectin degrading enzyme. In addition, human T cells produce proteas