Zobrazeno 1 - 10
of 68
pro vyhledávání: '"J Kimble, Frazer"'
Autor:
Dharambir K Sanghera, Ruth Hopkins, Megan W Malone-Perez, Cynthia Bejar, Chengcheng Tan, Huda Mussa, Paul Whitby, Ben Fowler, Chinthapally V Rao, KarMing A Fung, Stan Lightfoot, J Kimble Frazer
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0211661 (2019)
Dyslipidemia is a well-established risk factor for cardiovascular diseases. Although, advances in genome-wide technologies have enabled the discovery of hundreds of genes associated with blood lipid phenotypes, most of the heritability remains unexpl
Externí odkaz:
https://doaj.org/article/f4784dd491e54c79851cff426ec5aa4e
Autor:
Douglas K. Graham, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, Gary L. Johnson, William P. Janzen, Emily A. Hull-Ryde, Jacqueline Norris-Drouin, Catherine Simpson, Dmitri Kireev, Chao Yang, Jing Liu, Christopher T. Cummings, Debra M. Hunter, Susan Sather, Alesia Y. Trakhimets, Lance A. Batchelor, J. Kimble Frazer, Jennifer Schlegel, Deborah DeRyckere, Sandra Christoph
PDF - 164KB, Jurkat and 697 cell cultures were treated with UNC569 (500 nM) for 1 hour. Pervanadate was added to cell cultures for 3 minutes to stabilize the phosphorylated form of Mer. Cells were harvested after 24 and after 48 hours. Mer was immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b792aace27e76d7bcaa5f15a741f4e
https://doi.org/10.1158/1535-7163.22498869.v1
https://doi.org/10.1158/1535-7163.22498869.v1
Autor:
Douglas K. Graham, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, Gary L. Johnson, William P. Janzen, Emily A. Hull-Ryde, Jacqueline Norris-Drouin, Catherine Simpson, Dmitri Kireev, Chao Yang, Jing Liu, Christopher T. Cummings, Debra M. Hunter, Susan Sather, Alesia Y. Trakhimets, Lance A. Batchelor, J. Kimble Frazer, Jennifer Schlegel, Deborah DeRyckere, Sandra Christoph
PDF - 172KB, Jurkat cell cultures were treated with the indicated concentrations of UNC569 for 1 hour. Pervanadate was added to cell cultures for 3 minutes to stabilize the phosphorylated form of Tyro3. Tyro3 was immunoprecipitated from cell lysates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fd6e6b0eb551d5ec5540b41a540d51
https://doi.org/10.1158/1535-7163.22498872.v1
https://doi.org/10.1158/1535-7163.22498872.v1
Autor:
Douglas K. Graham, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, Gary L. Johnson, William P. Janzen, Emily A. Hull-Ryde, Jacqueline Norris-Drouin, Catherine Simpson, Dmitri Kireev, Chao Yang, Jing Liu, Christopher T. Cummings, Debra M. Hunter, Susan Sather, Alesia Y. Trakhimets, Lance A. Batchelor, J. Kimble Frazer, Jennifer Schlegel, Deborah DeRyckere, Sandra Christoph
PDF - 294KB, TAM receptor expression in Jurkat cell line was detected by western blot analysis. Whole cell lysates were prepared and phosphorylated (denoted by p-) and total proteins were detected. Western blots representative of three independent ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aaa550c21b0e6ea25a3b97df14e5550
https://doi.org/10.1158/1535-7163.22498875
https://doi.org/10.1158/1535-7163.22498875
Autor:
Douglas K. Graham, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, Gary L. Johnson, William P. Janzen, Emily A. Hull-Ryde, Jacqueline Norris-Drouin, Catherine Simpson, Dmitri Kireev, Chao Yang, Jing Liu, Christopher T. Cummings, Debra M. Hunter, Susan Sather, Alesia Y. Trakhimets, Lance A. Batchelor, J. Kimble Frazer, Jennifer Schlegel, Deborah DeRyckere, Sandra Christoph
PDF - 634KB, Eighteen fish (Myc1-Myc18) were treated with UNC569 for 2 weeks. Animals were imaged pre- and post-treatment, with GFP intensities quantified as described in the text. Ten of 18 fish (55.6%; Myc1-Myc8, Myc10, Myc16) showed >50% regressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff6aa50828c6ca22386951e59806f8d
https://doi.org/10.1158/1535-7163.22498863
https://doi.org/10.1158/1535-7163.22498863
Autor:
Douglas K. Graham, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, Gary L. Johnson, William P. Janzen, Emily A. Hull-Ryde, Jacqueline Norris-Drouin, Catherine Simpson, Dmitri Kireev, Chao Yang, Jing Liu, Christopher T. Cummings, Debra M. Hunter, Susan Sather, Alesia Y. Trakhimets, Lance A. Batchelor, J. Kimble Frazer, Jennifer Schlegel, Deborah DeRyckere, Sandra Christoph
PDF - 358KB, Cells were plated in methylcellulose in the presence of the indicated concentrations of UNC1653 or vehicle only. Colonies were counted after eight days. Long-term colony growth of Jurkat cells in methylcellulose is shown. Mean values and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d19ae5db09dd2cc4e5bb2320ddf698a
https://doi.org/10.1158/1535-7163.22498866
https://doi.org/10.1158/1535-7163.22498866
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Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 21, p 5313 (2019)
Despite advancements in the diagnosis and treatment of acute lymphoblastic leukemia (ALL), a need for improved strategies to decrease morbidity and improve cure rates in relapsed/refractory ALL still exists. Such approaches include the identification
Externí odkaz:
https://doaj.org/article/1da77b4c2a254d48bd2d1e0ba02c1304
Autor:
Landon Haslem, Jennifer M. Hays, Hannah Schmitz, Satoshi Matsuzaki, Virginie Sjoelund, Stephanie D. Byrum, Kenneth M. Humphries, J. Kimble Frazer, Borries Demeler, Doris M. Benbrook, Ryan M. Tierney, Kelli D. Duggan, Franklin A. Hays
SUMMARYp66Shc is an oxidoreductase that responds to cell stress by translocating to mitochondria, where p66Shc produces pro-apoptotic reactive oxygen species (ROS). This study identifies ROS-active p66Shc as a monomer that produces superoxide anion i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d04777717399a20a94b7ee8ef221511
https://doi.org/10.1101/2022.04.14.487897
https://doi.org/10.1101/2022.04.14.487897
Autor:
Pieter-Jan Volders, Megan Malone-Perez, J. Kimble Frazer, Pieter Van Vlierberghe, Givani Dewyn, Chiara Borga, Siebe Loontiens, Lance Batchelor, Wouter Van Loocke, Barbara Squiban, Suzanne Vanhauwaert, Finola E. Moore, Kaat Durinck, Lisa Depestel, David M. Langenau, Volodimir Olexiouk, Franki Speleman, Elaine G. Garcia
Publikováno v:
Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c7c872048b11cff1a1b0f503cb0d8f
https://doi.org/10.1038/s41375-020-0938-2
https://doi.org/10.1038/s41375-020-0938-2