Zobrazeno 1 - 10
of 6 764
pro vyhledávání: '"J Keith"'
Autor:
Weiting Zhang, Karl Petri, Junyan Ma, Hyunho Lee, Chia-Lun Tsai, J Keith Joung, Jing-Ruey Joanna Yeh
Publikováno v:
eLife, Vol 12 (2024)
CRISPR prime editing (PE) requires a Cas9 nickase-reverse transcriptase fusion protein (known as PE2) and a prime editing guide RNA (pegRNA), an extended version of a standard guide RNA (gRNA) that both specifies the intended target genomic sequence
Externí odkaz:
https://doaj.org/article/ad99b0e410504a6dbdf94fc1701017e7
Autor:
Omid Hamid, Diwakar Davar, Keisuke Shirai, Benjamin Izar, Charlotte E Ariyan, Michael K Wong, Jason J Luke, Janis M Taube, Anna C Pavlick, Meghan J Mooradian, Douglas B Johnson, Hussein A Tawbi, Tara C Mitchell, Ryan J Sullivan, April KS Salama, Krista M Rubin, Elizabeth I Buchbinder, Sarah A Weiss, Tina J Hieken, Geoffrey T Gibney, Rajan P Kulkarni, J Keith Tolley, Caressa Valdueza
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Since the first approval for immune checkpoint inhibitors (ICIs) for the treatment of cutaneous melanoma more than a decade ago, immunotherapy has completely transformed the treatment landscape of this chemotherapy-resistant disease. Combination regi
Externí odkaz:
https://doaj.org/article/f4721e0504094c6083b6710589696855
Autor:
Thomas J Sproule, Robert Y Wilpan, Benjamin E Low, Kathleen A Silva, Deepak Reyon, J Keith Joung, Michael V Wiles, Derry C Roopenian, John P Sundberg
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292456 (2023)
Previous work strongly implicated Collagen 17a1 (Col17a1) as a potent genetic modifier of junctional epidermolysis bullosa (JEB) caused by a hypomorphic mutation (Lamc2jeb) in mice. The importance of the noncollagenous domain (NC4) of COLXVII was sug
Externí odkaz:
https://doaj.org/article/678e25f859e64d80a1b1744863c9b5d2
Autor:
M J Brown, P Patel, E Nash, T Dikid, C Blanton, J E Forsyth, R Fontaine, P Sharma, J Keith, B Babu, T P Vaisakh, M J Azarudeen, B Riram, A Shrivastava
Publikováno v:
PLOS Global Public Health, Vol 2, Iss 10, p e0000743 (2022)
Childhood lead exposure remains a key health concern for officials worldwide, contributing some 600,000 new cases of intellectually disabled children annually. Most children affected by high exposure to lead live in low- and middle-income countries.
Externí odkaz:
https://doaj.org/article/58786f0c0a674f61b03f43e54a4777b4
Autor:
Christopher J Ricketts, J Keith Killian, Cathy D Vocke, Yonghong Wang, Maria J Merino, Paul S Meltzer, W Marston Linehan
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0278108 (2022)
Germline mutations within the Krebs cycle enzyme genes fumarate hydratase (FH) or succinate dehydrogenase (SDHB, SDHC, SDHD) are associated with an increased risk of aggressive and early metastasizing variants of renal cell carcinoma (RCC). These RCC
Externí odkaz:
https://doaj.org/article/0be1cdbe7b5840ebaf72c63a9f4e65ac
Autor:
Andrea Schmidts, Leah C Marsh, Ambike A Srivastava, Amanda A Bouffard, Angela C Boroughs, Rebecca C Larson, Felipe Bedoya, Bryan D Choi, Stefanie R Bailey, Mark B Leick, Sonika Vatsa, Michael C Kann, Michelle S Prew, Benjamin P Kleinstiver, J Keith Joung
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Adoptive cell therapy with chimeric antigen receptor T cells (CAR-T) has become a standard treatment for patients with certain aggressive B cell malignancies and holds promise to improve the care of patients suffering from numerous other c
Externí odkaz:
https://doaj.org/article/1383b25b9a8e4f49a0640c17e9556951
Autor:
Diane Armao, Terry S Hartman, Christopher M Shea, Laurence Katz, Tracey Thurnes, J Keith Smith
Publikováno v:
Journal of Medical Education and Curricular Development, Vol 5 (2018)
“I am not young enough to know everything.” Oscar Wilde Background: There is insufficient knowledge among providers and patients/caregivers of ionizing radiation exposure from medical imaging examinations. This study used a brief, interactive edu
Externí odkaz:
https://doaj.org/article/e3592e4ebf9646ecbfdcf0037a49f0fa