Zobrazeno 1 - 10
of 163
pro vyhledávání: '"J Kalervo, Hiltunen"'
Autor:
M. Tanvir Rahman, M. Kristian Koski, Joanna Panecka-Hofman, Werner Schmitz, Alexander J. Kastaniotis, Rebecca C. Wade, Rik K. Wierenga, J. Kalervo Hiltunen, Kaija J. Autio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mitochondrial fatty acid synthesis (mtFAS) is essential for respiratory function. MtFAS generates the octanoic acid precursor for lipoic acid synthesis, but the role of longer fatty acid products has remained unclear. The structurally well-c
Externí odkaz:
https://doaj.org/article/d16d0b2bf48f43899654c6293ec0c770
Autor:
Laura P. Pietikäinen, M. Tanvir Rahman, J. Kalervo Hiltunen, Carol L. Dieckmann, Alexander J. Kastaniotis
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-15 (2021)
Abstract Background Lipoylation of 2-ketoacid dehydrogenases is essential for mitochondrial function in eukaryotes. While the basic principles of the lipoylation processes have been worked out, we still lack a thorough understanding of the details of
Externí odkaz:
https://doaj.org/article/f012e0c5783342f1922b0a5e5a5651a5
Autor:
Antonina Shvetsova, Ali J. Masud, Laura Schneider, Ulrich Bergmann, Geoffray Monteuuis, Ilkka J. Miinalainen, J. Kalervo Hiltunen, Alexander J. Kastaniotis
Publikováno v:
MicrobiologyOpen, Vol 10, Iss 5, Pp n/a-n/a (2021)
Abstract Om45 is a major protein of the yeast's outer mitochondrial membrane under respiratory conditions. However, the cellular role of the protein has remained obscure. Previously, deletion mutant phenotypes have not been found, and clear amino aci
Externí odkaz:
https://doaj.org/article/d3405204928a4379ab2a3b9c6fb566a8
Autor:
Antonina N. Shvetsova, Daniela Mennerich, Juha M. Kerätär, J. Kalervo Hiltunen, Thomas Kietzmann
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 1052-1061 (2017)
Mitochondria are the main consumers of molecular O2 in a cell as well as an abundant source of reactive oxygen species (ROS). Both, molecular oxygen and ROS are powerful regulators of the hypoxia-inducible factor-1α-subunit (HIF-α). While a number
Externí odkaz:
https://doaj.org/article/98c4e796c2484e9ba92d17247ff4fc48
Autor:
Kaisa M. Kettunen, Riitta Karikoski, Riikka H. Hämäläinen, Teija T. Toivonen, Vasily D. Antonenkov, Natalia Kulesskaya, Vootele Voikar, Maarit Hölttä-Vuori, Elina Ikonen, Kirsi Sainio, Anu Jalanko, Susann Karlberg, Niklas Karlberg, Marita Lipsanen-Nyman, Jorma Toppari, Matti Jauhiainen, J. Kalervo Hiltunen, Hannu Jalanko, Anna-Elina Lehesjoki
Publikováno v:
Biology Open, Vol 5, Iss 5, Pp 584-595 (2016)
Mulibrey nanism (MUL) is a rare autosomal recessive multi-organ disorder characterized by severe prenatal-onset growth failure, infertility, cardiopathy, risk for tumors, fatty liver, and type 2 diabetes. MUL is caused by loss-of-function mutations i
Externí odkaz:
https://doaj.org/article/f8f2c0d5711c4276a5a02eaf172b5914
Autor:
Rajaram Venkatesan, Shruthi Sridhar, J. Kalervo Hiltunen, Ulrich Bergmann, Tiila Riikka Kiema, R.K. Wierenga, Werner Schmitz
Publikováno v:
Acta Crystallographica Section D Structural Biology
The peroxisomal multifunctional enzyme type 1 (MFE1) catalyzes two successive reactions in the β-oxidation cycle: the 2E-enoyl-CoA hydratase (ECH) and NAD+-dependent 3S-hydroxyacyl-CoA dehydrogenase (HAD) reactions. MFE1 is a monomeric enzyme that h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d6d6fc6556e6e03750806ecf3cedd3
https://doi.org/10.1107/s2059798320013819
https://doi.org/10.1107/s2059798320013819
Autor:
Marika Kangasniemi, Kaisu Luiro, Oskari Heikinheimo, Terhi Piltonen, Riikka K Arffman, Elina K Komsi, Juha S. Tapanainen, J. Kalervo Hiltunen, Annina Haverinen
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:e2483-e2490
Context Combined oral contraceptives (COCs) alter inflammatory status and lipid metabolism. Whether different estrogens have different effects is poorly understood. Objective We compared the effects of COCs containing ethinyl estradiol (EE) or estrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e95d5c25f62ae47114faf4d1dd99eee
https://doi.org/10.1210/clinem/dgaa186
https://doi.org/10.1210/clinem/dgaa186
Autor:
J. Kalervo Hiltunen, Tuomo Glumoff, Alexander J. Kastaniotis, Zhijun Chen, Guangyu Jiang, Kaija J. Autio
Publikováno v:
Molecular and Cellular Endocrinology. 489:107-118
17β-Hydroxysteroid dehydrogenases (HSD17B) catalyze the oxidation/reduction of 17β-hydroxy/keto group in position C17 in C18- and C19 steroids. Most HSD17Bs are also catalytically active with substrates other than steroids. A subset of these enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6840d4637af59a40af4c272cd2d0177
https://doi.org/10.1016/j.mce.2018.11.012
https://doi.org/10.1016/j.mce.2018.11.012
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53688 (2013)
Molecular basis of D-bifunctional protein (D-BP) deficiency was studied with wild type and five disease-causing variants of 3R-hydroxyacyl-CoA dehydrogenase fragment of the human MFE-2 (multifunctional enzyme type 2) protein. Complementation analysis
Externí odkaz:
https://doaj.org/article/a4b1ec5485804990a6b27f3921a68a2f
Autor:
Melisa Gualdron-López, Miia H Vapola, Ilkka J Miinalainen, J Kalervo Hiltunen, Paul A M Michels, Vasily D Antonenkov
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34530 (2012)
BACKGROUND: Glycosomes are a specialized form of peroxisomes (microbodies) present in unicellular eukaryotes that belong to the Kinetoplastea order, such as Trypanosoma and Leishmania species, parasitic protists causing severe diseases of livestock a
Externí odkaz:
https://doaj.org/article/9e09543587d240ac804bb5bb9e4f4ff0