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T cell receptor grafting allows virological control of hepatitis B virus infection

Autor: Karin Wisskirchen, Tassilo Volz, Marc Lütgehetmann, Stephan Urban, Jochen M. Wettengel, Maura Dandri, Lena Allweiss, J Kah, Ulrike Protzer, Theresa Asen, Tanja Bauer, Antje Malo

Publikováno v: J. Clin. Invest. 130, 2932-2945 (2019)

T cell therapy is a promising means to treat chronic hepatitis B virus (HBV) infection and HBV-associated hepatocellular carcinoma. T cells engineered to express an HBV-specific T cell receptor (TCR) may cure an HBV infection upon adoptive transfer.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d8010a6b673d9ff2159962162c9b8a
https://doi.org/10.1172/jci120228

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Hepatitis Delta Virus Acts as an Immunogenic Adjuvant in Hepatitis B Virus-Infected Hepatocytes

Autor: Anthony T. Tan, Tassilo Volz, Maura Dandri, J Kah, Marta Borghi, Yvonne Ladiges, Antonio Bertoletti, Marc Lütgehetmann, Pietro Lampertico, Adeline Chia, Camille Sureau, Christine Y.L. Tham, Alessandro Loglio, Katja Giersch

Publikováno v: Cell Reports Medicine, Vol 1, Iss 4, Pp 100060-(2020)
Cell Reports Medicine

Summary Hepatitis delta virus (HDV) requires hepatitis B virus (HBV) to complete its infection cycle and causes severe hepatitis, with limited therapeutic options. To determine the prospect of T cell therapy in HBV/HDV co-infection, we study the impa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a33bced8547233b91fc2051e2c7cf4e
http://www.sciencedirect.com/science/article/pii/S2666379120300768

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Murine hepatocytes do not support persistence of Hepatitis D virus mono-infection in vivo

Autor: Camille Sureau, John L. Casey, Lennart Hermanussen, Maura Dandri, Marc Lütgehetmann, Tassilo Volz, Katja Giersch, J Kah, Lena Allweiss

Publikováno v: Liver international : official journal of the International Association for the Study of the LiverREFERENCES. 41(2)

Backgrounds & aims As a result of the limited availability of in vivo models for hepatitis D virus (HDV), treatment options for HDV chronically infected patients are still scant. The discovery of sodium taurocholate cotransporting polypeptide (NTCP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4311ff08293bae2280e7cba33fc1b403
https://pubmed.ncbi.nlm.nih.gov/32997847

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Hepatitis Delta Virus Infection Increases the Efficacy of HBV-Specific T Cell-Based Therapies

Autor: Marta Borghi, Maura Dandri, Pietro Lampertico, Anthony T. Tan, J Kah, Yvonne Ladiges, Christine Y.L. Tham, Camille Sureau, Marc Lütgehetmann, Alessandro Loglio, Antonio Bertoletti, Adeline Chia, Katja Giersch, Tassilo Volz

Publikováno v: SSRN Electronic Journal.

Hepatitis Delta virus (HDV) requires hepatitis B virus (HBV) to complete its infection cycle and causes a severe hepatitis with limited therapeutic options. To determine the prospect of T cell therapy in HBV/HDV co-infection, we first studied the HDV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05efae7a5d010e5b9e35664f875b3634
https://doi.org/10.2139/ssrn.3545998

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