Zobrazeno 1 - 10
of 18
pro vyhledávání: '"J K McClung"'
Publikováno v:
Experimental Gerontology. 31:245-252
Prohibitin is an evolutionarily conserved gene that has antiproliferative activity, is ubiquitously expressed, and appears to be essential for cell survival. The gene codes for a 30 kD, post-synthetically modified protein located primarily in the mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b937837dc69e6ea580d106c9fd77d6
https://doi.org/10.1016/0531-5565(95)02009-8
https://doi.org/10.1016/0531-5565(95)02009-8
Publikováno v:
Experimental Cell Research. 218:577-580
Experiments were performed to determine whether prohibitin, an evolutionarily conserved gene with antiproliferative activity, has a role in cellular immortalization. A cell proliferation assay was used to examine one human cell line from each of four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6e0078d7e6dcd2a03b6c9d7395816e
https://doi.org/10.1006/excr.1995.1194
https://doi.org/10.1006/excr.1995.1194
Publikováno v:
Experimental Gerontology. 30:99-124
Prohibitin is an evolutionarily conserved gene with homologues found in organisms ranging from yeast to man. In man the gene is located on chromosome 17 at q21. The deduced amino acid sequences of the protein products from mouse and rat are identical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc5801ae389ae7c2df491107308d977
https://doi.org/10.1016/0531-5565(94)00069-7
https://doi.org/10.1016/0531-5565(94)00069-7
Publikováno v:
Biochemical and Biophysical Research Communications. 201:409-414
Prohibitin is an evolutionarily conserved gene postulated to possess tumor suppressor activity and to contribute to the limited lifespan of human diploid fibroblast-like cells. Prohibitin mRNA and protein expression and its ability to become post-tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd912e155263dce8c87009014f95d49b
https://doi.org/10.1006/bbrc.1994.1716
https://doi.org/10.1006/bbrc.1994.1716
Autor:
J. K. Mcclung, Mark J. Nuell, David B. Danner, L. S. Walker, R T Dell'Orco, C. A. Stewart, R. L. King
Publikováno v:
Experimental Gerontology. 27:413-417
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343ff632e20aba79309f59cce1390130
https://doi.org/10.1016/0531-5565(92)90074-a
https://doi.org/10.1016/0531-5565(92)90074-a
Autor:
J. K. McClung
Publikováno v:
Mitochondrial DNA Mutations in Aging, Disease and Cancer ISBN: 9783662125113
The prohibitin story begins with the development of an assay for the detection of mRNAs that could inhibit the initiation of DNA synthesis.1’2 Messenger RNAs were tested by microinjecting them into individual human diploid fibroblasts that had been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d115a2372f8b8cb26e831c0861290769
https://doi.org/10.1007/978-3-662-12509-0_17
https://doi.org/10.1007/978-3-662-12509-0_17
Autor:
Sukanya Narasimhan, Frank F. Richards, Martine Y. K. Armstrong, Eleanor K. Spicer, J K McClung
Publikováno v:
Infection and immunity. 65(12)
Little is known about the molecules involved in the regulation of Pneumocystis carinii replication and development in vitro and in vivo. We describe in this report the identification of a P. carinii gene encoding the P. carinii prohibitin protein. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a29db8d2c019f8eaaf1a0bad52857b
https://pubmed.ncbi.nlm.nih.gov/9393805
https://pubmed.ncbi.nlm.nih.gov/9393805
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 7(7)
The evolutionarily conserved prohibitin gene is located on human chromosome 17q21, and two alleles have been identified. Our previous studies characterizing prohibitin in immortalized cells, classified into four complementation groups (A-D) based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83140496457490ce0793bf208665f9eb
https://pubmed.ncbi.nlm.nih.gov/8809404
https://pubmed.ncbi.nlm.nih.gov/8809404
Publikováno v:
Experimental cell research. 224(1)
We have been studying the role of the evolutionarily conserved prohibitin gene in cellular immortalization and tumor suppression. Immortalized human cells are classified into four complementation groups (A, B, C, and D) based on the ability of fusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c9378c35ef9337506bfbd5e64d99a1
https://pubmed.ncbi.nlm.nih.gov/8612677
https://pubmed.ncbi.nlm.nih.gov/8612677
Autor:
David A. Stewart, Garrison Owens, M. S. Altus, Carla M. Wood, Varda Friedman, David B. Danner, Xiao-Tie Liu, L. Walker, A. J. Roskams, J. K. Mcclung
Publikováno v:
Journal of cellular physiology. 157(2)
Prohibitin, a novel intracellular antiproliferative protein, blocks entry into the S phase of the cell division cycle when its mRNA is microinjected into normal fibroblasts or HeLa cells. To learn more about the interaction between prohibitin and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7779a003864a9021d40670b0639691f9
https://pubmed.ncbi.nlm.nih.gov/8227162
https://pubmed.ncbi.nlm.nih.gov/8227162