Výsledky vyhledávání

New benzylpyrimidines: inhibition of DHFR from various species. QSAR, CoMFA and PC analysis

Autor: Wolfram Hänsel, M. Wiese, K.-H. Czaplinski, J. K. Seydel

Publikováno v: European Journal of Medicinal Chemistry. 30:779-787

Summary To further analyze the structural requirements responsible for the enhanced activity of the newly developed, highly active benzylpyrimidine K-130, a series of trimethoprim analogues with various 4-anilinoalkoxy moieties has been synthesized a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac2e2d36334b74f67fb815df5016c10a
https://doi.org/10.1016/0223-5234(96)88297-3

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[The problem of resistance in the treatment of Mycobacterium infections: new experimental results and combinations for the treatment of tuberculosis and leprosy]

Autor: J K, Seydel, K J, Schaper

Publikováno v: Pharmazie in unserer Zeit. 24(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3fd608a15d06017bd42054fd8cf11b9
https://pubmed.ncbi.nlm.nih.gov/8592712

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Substituted 2-acylpyridine-alpha-(N)-hetarylhydrazones as inhibitors of ribonucleotide reductase activity and L1210 cell growth

Autor: J G, Cory, D L, Downes, A H, Cory, K J, Schaper, J K, Seydel

Publikováno v: Anticancer research. 14(3A)

A series of substituted 2-acylpyridine-alpha-(N)-hetarylhydrazones was prepared and studied for their effects on mammalian ribonucleotide reductase activity using a highly purified enzyme preparation from Ehrlich tumor cells and on mouse leukemia L12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d9c298999e1724ce1789e27f0dc4f7a
https://pubmed.ncbi.nlm.nih.gov/8074487

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Influence of membrane composition of various parasites on the inhibitory activity of a series of bipyridyl analogues

Autor: H. Timmerman, H. Van der Goot, J. K. Seydel

Publikováno v: Chemotherapy. 40(2)

In a previous report the dependence of the antimycoplasmal activity of bipyridyl analogues on the presence of Cu+ ions has been shown. The inhibitory activity of these compounds has now been studied against Escherichia coli mycobacteria and Candida a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae3664e04a2453e260b15ca4d928895
https://pubmed.ncbi.nlm.nih.gov/8131634

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In vitro and in vivo results of brodimoprim and analogues alone and in combination against E. coli and mycobacteria

Autor: J K, Seydel

Publikováno v: Journal of chemotherapy (Florence, Italy). 5(6)

New diaminodiphenylsulfone inhibitors of dihydropteroate synthase are described with increased inhibitory activity against mycobacteria and plasmodia, whereas their side effect of methemoglobin formation could be suppressed. The optimization of diami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2753ee00cbbac20e4e2542768a4f015d
https://pubmed.ncbi.nlm.nih.gov/8195833

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Critical comments on the treatment of leprosy and other mycobacterial infections with clofazimine

Autor: E, Freerksen, J K, Seydel

Publikováno v: Arzneimittel-Forschung. 42(10)

The usefulness of clofazimine (CLO, CAS 2030-63-9) in the treatment of mycobacterial infections with special emphasis on treatment of leprosy is critically discussed. Skin discolouration which decreases compliance, placenta passage, excretion in moth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b4c0d040dbd1702fb6c600179cd9cc23
https://pubmed.ncbi.nlm.nih.gov/1472145

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Development of effective drug combinations for the inhibition of multiply resistant mycobacteria, especially of the Mycobacterium avium complex

Autor: J K, Seydel, K J, Schaper, S, Rüsch-Gerdes

Publikováno v: Chemotherapy. 38(3)

Rationally designed combinations of rifampicin (RAMP) and thiacetazone plus isonicotinic acid hydrazide and/or ethambutol are highly effective in the treatment of patients (including HIV-positive) infected with multiply resistant mycobacteria of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f24fc2dcca838f8819feb24485088694
https://pubmed.ncbi.nlm.nih.gov/1380906

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A new series of 2,2'-bipyridyl analogues with high activity against AIDS-complicating micro-organisms

Autor: H. Van der Goot, H. Timmerman, J. K. Seydel

Publikováno v: Pharmaceutisch weekblad. Scientific edition. 13(2)

I t has been general ly accepted tha t the acquired immuno-deficiency syndrome (AIDS) is characterized by a defect in the cell-mediated immuno-response; the selective destruction is caused by the h u m a n immuno-deficiency virus (HIV), HIV infection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3071f25f086e51865584d97563cfabf0
https://pubmed.ncbi.nlm.nih.gov/1870942

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