Zobrazeno 1 - 10
of 44
pro vyhledávání: '"J K, Selkirk"'
Publikováno v:
Proceedings of the National Academy of Sciences. 92:11534-11538
Variants of chemically immortalized Syrian hamster embryo cells that had either retained (supB+) or lost (supB-) the ability to suppress tumorigenicity when hybridized with a fibrosarcoma cell line were subcloned. Both supB cell types are nontumorige
Publikováno v:
Cancer research. 57(14)
We previously generated cell hybrids between a derivative of the E6-containing HeLa cell line and a p53 null peripheral neuroepithelioma (PNET) cell line. Although p53 protein from the hybrids was genotypically wild type, it did not demonstrate wild-
Publikováno v:
BioTechniques. 18(2)
Phosphor imaging was evaluated for detection, quantitation and resolution of multiphosphorylated protein isoforms separated by two-dimensional gel electrophoresis. A nuclear phosphoprotein, p53, was isolated by immunoprecipitation after biosynthetic
Publikováno v:
Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society. 5(1)
Embryonic fibroblasts derived from p53-deficient transgenic mice showed distinct phenotypic and biological changes in vitro. In this study, we investigated the possible impact of p53 on the synthesis of other cellular proteins by comparing the protei
Autor:
J. K. Selkirk
Publikováno v:
Pure and Applied Chemistry. 75:2413-2414
Toxicology is the science of adverse effects of chemicals, drugs, environmental agents, and stressors. Genomics defines the structure, sequence (code), and function of the entire DNA complement of organisms. The interface of these diverse disciplines
Publikováno v:
Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society. 4(1)
At least eleven isoforms of p53 protein were observed in a human mammary tumor cell line. T47D. Comparative 33P and 35S incorporation analysis showed an equal distribution of P53 isoforms within cytoplasmic and nuclear compartments, although phosphor
Publikováno v:
Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society. 4(2)
Embryonic mouse cells containing a disrupted p53 gene (-/-) were compared to the heterozygote (+/-) and homozygote control (+/+) for growth characteristics and the presence of p53 protein isoforms. There were considerable morphological differences be
Publikováno v:
BioTechniques. 14(5)
Publikováno v:
Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society. 3(5)
Proteins from leukemic spleen cells derived from a F344 rat transplant model were investigated by 2D gel electrophoresis. The cell line was maintained in vivo by serial transplant of mononuclear spleen cells from leukemic donors into syngeneic recipi