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pro vyhledávání: '"J K, Roche"'
Autor:
J K, Roche
Publikováno v:
Methods in molecular medicine. 50
While in situ techniques have been valuable in identifying the presence and localization of cytoplasmic and membrane components in tissue (1), there is often a need to study directly one or more cell types, free from its own microenvironment. For the
Autor:
R, Cosme, J K, Roche
Publikováno v:
Methods in molecular medicine. 50
The mucosa of the colon occupies 25% of the intestinal wall, from the muscularis mucosa to the lumen-lining epithelium, and contains a variety of cell types, predominantly B and T lymphocytes, but also monocytes, mast cells, and macrophages (1,2). Th
Publikováno v:
The Journal of Immunology. 150:5281-5288
In mucosa-bearing organs with inherent lymphoid populations, classical modes for control of the immune response may be augmented by products of extrinsic sensory afferent nerve endings which arborize through the lamina propria compartment containing
Publikováno v:
The Journal of Immunology. 150:2356-2363
The single cell-thick intestinal epithelium forms a crucial barrier between the host and environment, and is modeled in vitro by a monolayer of polarized, highly differentiated T84 epithelial cells impermeable to most macromolecules because of functi
Publikováno v:
Clinical Microbiology Reviews. 4:270-285
In recent years, the relationship between human papillomaviruses (HPV) and genital neoplasia has been explored intensively, and a molecular basis for the role of HPV in the genesis of these diseases has been convincingly demonstrated. These findings
Publikováno v:
Journal of cellular physiology. 181(1)
Freshly isolated human mucosal T lymphocytes in vitro can markedly diminish an important property of intestinal epithelium-its barrier function. On the other hand, cytokines and their cellular receptors, which maintain homeostasis of epithelia, limit
Publikováno v:
Digestive diseases and sciences. 42(4)
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 153(12)
Maintenance of the integrity of the single-cell-thick intestinal epithelium as an in vivo barrier between environmental Ags and mucosal immunocytes is pivotal for health. The T cell cytokine IFN-gamma consistently disrupts this epithelial barrier in
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 150(12)
In mucosa-bearing organs with inherent lymphoid populations, classical modes for control of the immune response may be augmented by products of extrinsic sensory afferent nerve endings which arborize through the lamina propria compartment containing
Publikováno v:
Digestive diseases and sciences. 38(6)
Mucosal and submucosal mast cell hyperplasia is a feature of the chronic inflammatory bowel diseases--ulcerative colitis and Crohn's disease. The mast cells are often seen to be degranulated in areas of active disease, suggesting that the inflammator