Zobrazeno 1 - 10 of 46 pro vyhledávání: '"J K, Rees"'
1
Comparison of 'sequential' versus 'standard' chemotherapy as re-induction treatment, with or without cyclosporine, in refractory/relapsed acute myeloid leukaemia (AML): results of the UK Medical Research Council AML-R trial
Autor: J A, Liu Yin, K, Wheatley, J K, Rees, A K, Burnett
Publikováno v: British journal of haematology. 113(3)
This aim of the acute myeloid leukaemia (AML)-R trial was to compare sequential (Seq) ADE (cytarabine, daunorubicin, etoposide) with standard (Std) ADE as remission re-induction treatment and to assess any benefit of cyclosporine (CSA) as a multidrug
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::abfb9b5c80ef2c3e78f5c1406903688e
https://pubmed.ncbi.nlm.nih.gov/12823362
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2
A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial. United Kingdom Medical Research Council's Adult and Childhood Leukaemia Working Parties
Autor: K, Wheatley, A K, Burnett, A H, Goldstone, R G, Gray, I M, Hann, C J, Harrison, J K, Rees, R F, Stevens, H, Walker
Publikováno v: British journal of haematology. 107(1)
Data on 1711 patients, aged up to 55 years, in the MRC AML 10 trial were used to create a prognostic index for use in risk-directed therapy decision making for younger patients with acute myeloid leukaemia (AML). Two parameters, response after course
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a86b1fdf8293794782e1b1529c02f9ff
https://pubmed.ncbi.nlm.nih.gov/10520026
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3
Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of MRC AML 10 trial. UK Medical Research Council Adult and Children's Leukaemia Working Parties
Autor: A K, Burnett, A H, Goldstone, R M, Stevens, I M, Hann, J K, Rees, R G, Gray, K, Wheatley
Publikováno v: Lancet (London, England). 351(9104)
Three strategies are used to prevent relapse in patients with acute myeloid leukaemia in first remission. Most of those with suitable donors are offered allogeneic haemopoietic-stem-cell transplant. Other patients may receive intensive chemotherapy o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1cf6870a384f8ccd6fc90bbe0ada7b94
https://pubmed.ncbi.nlm.nih.gov/9504514
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5
Dose intensification in acute myeloid leukaemia: greater effectiveness at lower cost. Principal report of the Medical Research Council's AML9 study. MRC Leukaemia in Adults Working Party
Autor: J K, Rees, R G, Gray, K, Wheatley
Publikováno v: British journal of haematology. 94(1)
Between 1984 and 1990, 972 patients aged 1-79 years with acute myeloid leukaemia (AML), from 85 British hospitals, were entered into the MRC's 9th AML trial. Patients were randomized between DAT 1 + 5 (daunorubicin for 1 d, with cytarabine and 6-thio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2c204cba3341c6466a30f144bffc7e7
https://pubmed.ncbi.nlm.nih.gov/8757514
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6
Chemotherapy versus transplants for acute myelogenous leukemia in second remission
Autor: R P, Gale, M M, Horowitz, J K, Rees, R G, Gray, M M, Oken, E H, Estey, K M, Kim, M J, Zhang, R C, Ash, K, Atkinson, R E, Champlin, K A, Dicke, J L, Gajewski, J M, Goldman, W, Helbig, P S, Henslee-Downey, W, Hinterberger, N, Jacobsen, A, Keating, J P, Klein, A M, Marmont, H G, Prentice, J, Reiffers, A A, Rimm, M M, Bortin
Publikováno v: Leukemia. 10(1)
The best therapy for persons with acute myelogenous leukemia (AML) in 2nd remission is unknown. Bone marrow transplants from an HLA-identical sibling are reported to be better than chemotherapy but this is controversial. The objective of the study wa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6130437b4e02dd330bebb81b4512987f
https://pubmed.ncbi.nlm.nih.gov/8558917
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7
Aspects of treatment of acute myeloid leukemia in adults
Autor: J K, Rees
Publikováno v: Current opinion in oncology. 5(1)
The treatment of acute myeloid leukemia has made steady rather than spectacular progress in the past few years, principally because of improved supportive care. The use of hematopoietic growth factors may contribute to the speed of normal bone marrow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e2b86b9dc596376b73e3bad83de1fc4
https://pubmed.ncbi.nlm.nih.gov/8427894
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8
Resistance circumvention strategies tested in clinical leukaemia specimens using the MTT colorimetric assay
Autor: E, Lambert, J K, Rees, P R, Twentyman
Publikováno v: Leukemia. 6(10)
We have used a 4-day MTT colorimetric assay to study drug sensitivity of leucocytes from leukaemia patients and from normal donors. Response to Adriamycin, vincristine, aclacinomycin A, 3'-deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin (MX2),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e49fd8ecea44d8c56835a4ff4932b7c
https://pubmed.ncbi.nlm.nih.gov/1405760
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9
Selective toxicity of ethacrynic acid towards lymphocytes of chronic lymphocytic leukemia in vitro
Autor: P R, Twentyman, E, Lambert, M, Müller, J K, Rees
Publikováno v: Leukemia. 6(7)
We have used the MTT colorimetric assay to determine the sensitivity to ethacrynic acid of lymphocytes from normal donors and of peripheral blood cells from leukaemia patients. Whereas normal lymphocytes and cells from acute or chronic myeloid leukae
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7542115670246669e981d9d07a414727
https://pubmed.ncbi.nlm.nih.gov/1625494
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