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pro vyhledávání: '"J K, Marquis"'
Publikováno v:
Alimentary Pharmacology and Therapeutics. 24:1525-1534
Summary Background Tolevamer is a novel toxin-binding polymer that is currently being investigated in clinical trials for the treatment of patients who have Clostridium difficile-associated diarrhoea. Aims To summarize the results of in vitro and in
Autor:
J K, Marquis, J M, Grindel
Publikováno v:
Current opinion in molecular therapeutics. 2(3)
In this brief review, guidance is provided for the safety evaluation of phosphorothioate oligonucleotides. This novel class of compounds has proved to be challenging for the preclinical development scientist, as systemic exposure can evoke sometimes
Autor:
B H, Dvorchik, J K, Marquis
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(10)
The ocular disposition and toxicity of GEM132, a mixed backbone phosphorothioate oligonucleotide developed for the treatment of cytomegalovirus-induced retinitis, were studied in rabbits for 6 months following single intravitreal injection of 5, 20,
Autor:
L S, Katz, J K, Marquis
Publikováno v:
Neurotoxicology. 13(2)
Low level, chronic exposure (0.1 nM, 24 hrs) to the organophosphate paraoxon significantly inhibits N-[3H]methylscopolamine ([3H]NMS) binding to muscarinic receptors in a noncompetitive manner in the SK-N-SH neuroblastoma cell line. The effect of par
Publikováno v:
Alcoholism: Clinical and Experimental Research. 4:282-287
Prolonged ethanol consumption produces neuropathology and neurologic symptoms in humans and experimental animals. As a means of understanding the central nervous system (CNS) consequences of ethanol abuse, we sought whether cholinergic neurochemical
Autor:
J. K. Marquis
Publikováno v:
Journal - American Water Works Association. 24:728-732
A knowledge of the science of microbiology is essential to a well rounded experience of a water plant chemist. Such a knowledge is much to be desired and striven for but the science cannot be learned in a day. To be able to recognize the many differe
Publikováno v:
Cholinergic Mechanisms ISBN: 9781468486452
The postulate (18) that the acetylcholine (ACh) cycle plays an essential part in controlling the cation permeability of electrically excitable postsynaptic membranes is accepted generally.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a655e78f96fd393cf8fb6d5fbf74a9f1
https://doi.org/10.1007/978-1-4684-8643-8_37
https://doi.org/10.1007/978-1-4684-8643-8_37
Autor:
J K, Marquis, H G, Mautner
Publikováno v:
Molecular pharmacology. 11(3)
Interaction of neuroactive drugs and group-specific ligands with purified human serum cholinesterase
Autor:
J K, Marquis
Publikováno v:
Neurotoxicology. 6(2)