Zobrazeno 1 - 2
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pro vyhledávání: '"J K, Kidney"'
Autor:
S R, Channel, J R, Latendresse, J K, Kidney, J H, Grabau, J W, Lane, L, Steel-Goodwin, M C, Gothaus
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 43(2)
The common groundwater contaminant trichloroethylene (TCE), when given by oral gavage, can produce free radical species during metabolism. Furthermore, TCE end-stage metabolites, trichloroacetic acid and dichloroacetic acid, cause lipid peroxidation
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(12)
Chloral hydrate (CH) and its metabolites, trichloroacetate (TCA) and dichloroacetate (DCA), have been shown to induce liver tumors in male B6C3F1 mice. The pharmacokinetics of CH and its metabolites play an important role in its toxicity. This study