Zobrazeno 1 - 10
of 52
pro vyhledávání: '"J K, Inman"'
Publikováno v:
The Journal of Immunology. 159:3782-3791
The present studies have examined whether the potential of an Ag to co-ligate the complement (C3d)-binding CD21 receptor complex with the membrane IgM (mIgM) receptor complex can reduce the mIgM:Ag affinity threshold for triggering human B cell S pha
Publikováno v:
The Journal of Immunology. 157:1397-1405
In the present study, we analyze the role of Ig receptor cross-linking in T cell-dependent stimulation of both preswitch (surface IgM+ (sIgM+/sIgD+) B cells and postswitch (sIgA+) B cells. We demonstrate that purified sIgA+ B cells pretreated with an
Publikováno v:
Journal of Liposome Research. 6:397-414
The humoral immune response to haptenated liposomes is well documented. This review summarizes our efforts in this field of research. The immunogenicity of haptens, small oligosaccharides and peptides linked to phosphatidyl ethanolamine are studied i
Publikováno v:
The Journal of Immunology. 155:3385-3400
Given the range of mIg-binding affinities expressed by Ag-specific B cells, the ligand:receptor affinity threshold for achieving full B cell activation via the mIgM-mediated signaling pathway is quite high. Several recombinant, or semi-purified, cyto
Publikováno v:
The Journal of Immunology. 151:6757-6768
The Ag, pigeon cytochrome c, was coupled to human ferric transferrin by a heteroligation technique to target Ag into the endosomal transport pathway via transferrin receptors. The ability of various types of APC that do or do not express transferrin
Publikováno v:
The Journal of Immunology. 151:4583-4594
The Ag, pigeon cytochrome c, was delivered to the early endosomes in a form coupled to human ferric transferrin that entered APC through transferrin receptors. The processing of the transferrin-Ag conjugate by B lymphoma cells was compared with that
Publikováno v:
The Journal of Immunology. 150:1691-1704
The role of endosomes in exogenous Ag processing was investigated by targeting Ag into the endosomal transport pathway via transferrin receptors. The Ag, pigeon cytochrome c and chicken OVA, were coupled to human ferric transferrin by a heteroligatio
Publikováno v:
The Journal of Immunology. 148:3892-3901
The potential for ligand-initiated signal transduction through B cell membrane IgM is assessed in terms of ligand concentration, binding site valency, and binding site affinity for membrane Ig. Estimates of the physicochemical requirements for achiev
Publikováno v:
Investigative ophthalmologyvisual science. 41(8)
Thrombospondin (TSP)1 is a tumor suppressor with activity that is associated with its ability to inhibit neovascularization. Previous studies have mapped this antiangiogenic activity to the type 1 repeats and the amino-terminal portion of the molecul
Autor:
V, Basrur, Y, Song, S J, Mazur, Y, Higashimoto, J A, Turpin, W G, Rice, J K, Inman, E, Appella
Publikováno v:
The Journal of biological chemistry. 275(20)
The synthesis and antiviral properties of pyridinioalkanoyl thioester (PATE) compounds that target nucleocapsid p7 protein (NCp7) of the human immunodeficiency virus type 1 (HIV-1) have been described previously (Turpin, J. A., Song, Y., Inman, J. K.