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Engineering of Human Adipose-Derived Mesenchymal Stem-Like Cells

Autor: Brian M. Strem, J. K. Fraser, M. Zhu, M. H. Hedrick

Publikováno v: Genetic Engineering of Mesenchymal Stem Cells ISBN: 9781402039355

In summary, adipose contains a population of cells that has extensive self-renewal capacity and the ability to differentiate along multiple lineages. The cells possessing this activity can be obtained in large numbers at high frequency from a tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9469e0e187580911d19c135bfb875a3e
https://doi.org/10.1007/1-4020-3959-x_6

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Apoptosis and megakaryocytic differentiation during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin

Autor: K H, Ryu, S, Chun, S, Carbonierre, S A, Im, H L, Kim, M H, Shin, H Y, Shin, H S, Ahn, S Y, Woo, J Y, Seoh, J K, Fraser

Publikováno v: British journal of haematology. 113(2)

Thrombopoietin (TPO), the primary regulator of megakaryocytopoiesis, plays important roles in early haematopoiesis. Previously, we have demonstrated that TPO induces a characteristic pattern of apoptosis during ex vivo expansion of cord blood (CB) CD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb4d11e6accabc0d7256e2021bd37933
https://pubmed.ncbi.nlm.nih.gov/11380418

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Characterization of HOX gene expression during myelopoiesis: role of HOX A5 in lineage commitment and maturation

Autor: J F, Fuller, J, McAdara, Y, Yaron, M, Sakaguchi, J K, Fraser, J C, Gasson

Publikováno v: Blood. 93(10)

During the process of normal hematopoiesis, proliferation is tightly linked to maturation. The molecular mechanisms that lead to production of mature effector cells with a variety of phenotypes and functions from a single multipotent progenitor are o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e54e4f305667296e9a982598f9a5df7
https://pubmed.ncbi.nlm.nih.gov/10233891

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The biology of the cytokine sequence cascade

Autor: J K, Fraser, M C, Lill, R A, Figlin

Publikováno v: Seminars in oncology. 23(2 Suppl 4)

Pretransplant and posttransplant use of hematopoietic growth factors in bone marrow transplantation (BMT) has shortened the time to engraftment. Severe neutropenia and thrombocytopenia have been the major clinical problems associated with autologous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2ca58f33068c35bbc2062aee6537d81
https://pubmed.ncbi.nlm.nih.gov/8600544

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Polypyrimidine tract-binding protein and heterogeneous nuclear ribonucleoprotein A1 bind to human T-cell leukemia virus type 2 RNA regulatory elements

Autor: A C Black, J Luo, C Watanabe, S Chun, A Bakker, J K Fraser, J P Morgan, J D Rosenblatt

Efficient expression of human T-cell leukemia virus (HTLV) and human immunodeficiency virus structural proteins requires Rx and Rev proteins, respectively. Decreased expression of Gag and Env appears to be due, in part, to intragenic RNA sequences, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356a8120f937b1a760dc8407a65d75d4
https://europepmc.org/articles/PMC189599/

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Characterization of nuclear factors that bind to a critical positive regulatory element of the human granulocyte-macrophage colony-stimulating factor promoter

Autor: J K, Fraser, S, Tran, S D, Nimer, J C, Gasson

Publikováno v: Blood. 84(8)

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that stimulates the proliferation, maturation, and functional activity of myeloid cells in peripheral blood and bone marrow. Expression of GM-CSF is tightly re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eeaee47dcde4864e6020e2ef5f16d02f
https://pubmed.ncbi.nlm.nih.gov/7919370

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Human granulocyte-macrophage colony-stimulating factor (GM-CSF): regulation of expression

Autor: J C, Gasson, J K, Fraser, S D, Nimer

Publikováno v: Progress in clinical and biological research. 338

GM-CSF is a potent hematopoietic growth factor which exerts its effects on hematopoietic cell growth both in vivo and in vitro. In addition, GM-CSF has profound effects enhancing the functional activity of circulating effector cells. GM-CSF can be pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21a0af9aab55227db8ad1f804b666635
https://pubmed.ncbi.nlm.nih.gov/2189139

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Effects of recombinant human erythropoietin on megakaryocytes and on platelet production in the rat

Autor: M V, Berridge, J K, Fraser, J M, Carter, F K, Lin

Publikováno v: Blood. 72:970-977

The contention that erythropoietin (Epo) affects platelet production was investigated in the rat with recombinant human Epo (rHuEpo). In normal rats, Epo caused a dose-dependent increase in both reticulocyte and platelet numbers, the reticulocyte res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d78f9302f0ebd5248244624c9318d7
https://doi.org/10.1182/blood.v72.3.970.bloodjournal723970

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