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Dissecting Bottromycin Biosynthesis Using Comparative Untargeted Metabolomics

Autor: Andrew W. Truman, William J. K. Crone, Lukas G Schmitz, Natalia M. Vior, Javier Santos-Aberturas, Finian J. Leeper

Publikováno v: Angewandte Chemie (International Ed. in English)

Bottromycin A2 is a structurally unique ribosomally synthesized and post‐translationally modified peptide (RiPP) that possesses potent antibacterial activity towards multidrug‐resistant bacteria. The structural novelty of bottromycin stems from i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3177b2c883a893ef1abeee9645b6c9ed
https://doi.org/10.1002/anie.201604304

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The Effect of Parkinson's-Disease-Associated Mutations on the Deubiquitinating Enzyme UCH-L1

Autor: Elizabeth F. Werrell, Sophie E. Jackson, Chittarnajan Das, Shang-Te Danny Hsu, Lindsay M. McMorran, William J. K. Crone, Fredrik Andersson

Publikováno v: Journal of Molecular Biology. 407:261-272

The neuronal ubiquitin C-terminal hydrolase (UCH) UCH-L1 has been linked to Parkinson's disease (PD) and other neurodegenerative diseases. Here, we present a study on the structure, stability, unfolding, and dynamics of wild-type and mutant UCH-L1. F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b5e20a2bc1d061558c2e6d7d20ebd5
https://doi.org/10.1016/j.jmb.2010.12.029

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The effect of HNE modification on the structure and function of the neuronal protein UCH-L: Links to neurodegenerative disease

Autor: William J. K. Crone, B. Murphy, S.K. Wetzel, S.T. Hsu, E.F. Werrell, Sophie E. Jackson

Publikováno v: Free Radical Biology and Medicine. 53:S241-S242

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::faba3b0ef827277d9cd4b82d7965951b
https://doi.org/10.1016/j.freeradbiomed.2012.08.025

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Impaired ovulation in mice with targeted deletion of the neuronal isoform of nitric oxide synthase

Autor: S L, Klein, D, Carnovale, A L, Burnett, E E, Wallach, H A, Zacur, J K, Crone, V L, Dawson, R J, Nelson, T M, Dawson

Publikováno v: Molecular medicine (Cambridge, Mass.). 4(10)

BACKGROUND: Nitric oxide (NO) plays an important role in numerous reproductive processes. To date, most studies have assessed the role of NO by using nonspecific pharmacological inhibitors of the precursor to NO, nitric oxide synthase (NOS). These ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67447865e53fcbd4894a1d61942d1a40
https://pubmed.ncbi.nlm.nih.gov/9848082

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Partial sympathetic denervation of the rat epididymis permits fertilization but inhibits embryo development

Autor: D D, Ricker, J K, Crone, S L, Chamness, G R, Klinefelter, T S, Chang

Publikováno v: Journal of andrology. 18(2)

The rat cauda epididymidis receives sympathetic innervation from the inferior mesenteric ganglion (IMG). We have previously demonstrated that surgical removal of the IMG and proximal hypogastric nerves (IMG denervation) results in significant and cau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::465e0002e0bd39889d39840d7f3ffe5c
https://pubmed.ncbi.nlm.nih.gov/9154507

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The effect of androgen on nitric oxide synthase in the male reproductive tract of the rat

Autor: S L, Chamness, D D, Ricker, J K, Crone, C L, Dembeck, M P, Maguire, A L, Burnett, T S, Chang

Publikováno v: Fertility and sterility. 63(5)

To determine if nitric oxide synthase activity within the male reproductive tract is regulated by androgen.Nitric oxide synthase activity was measured in the reproductive organs of three groups of mature rats: unoperated controls, 1-week castrates, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f2efacb4cb3042d40242d40b1ce4a60
https://pubmed.ncbi.nlm.nih.gov/7536692

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Localization of nitric oxide synthase in the reproductive organs of the male rat

Autor: A L, Burnett, D D, Ricker, S L, Chamness, M P, Maguire, J K, Crone, D S, Bredt, S H, Snyder, T S, Chang

Publikováno v: Biology of reproduction. 52(1)

Nitric oxide synthase (NOS), which catalyzes the production of nitric oxide (NO), was characterized within the reproductive tract of adult male Sprague-Dawley rats by means of biochemical and immunohistochemical techniques. Tissues examined included

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67247eabea8c9b68d23ad304e21f0e19
https://pubmed.ncbi.nlm.nih.gov/7536043

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Identification and characterisation of the gene cluster for the anti-MRSA antibiotic bottromycin: expanding the biosynthetic diversity of ribosomal peptides

Autor: William J. K. Crone, Andrew W. Truman, Finian J. Leeper

Publikováno v: Chemical Science. 3:3516

Streptomycete bacteria are a rich source of antibacterial natural products. Increasing antibiotic resistance is a global concern and novel classes of potent antibiotics are rare. Here we report the identification and genetic manipulation of the gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::410ea8a44560a3594d1dae0288ec8bbc
https://doi.org/10.1039/c2sc21190d

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