Effect of high dose vitamin D3 on the HIV-1 reservoir: A pilot randomised controlled trial

Autor: Matthew C. Pitman, Niamh Meagher, David J. Price, Ajantha Rhodes, J. Judy Chang, Barbara Scher, Brent Allan, Alan Street, James H. McMahon, Thomas A. Rasmussen, Paul U. Cameron, Jennifer F. Hoy, Stephen J. Kent, Sharon R. Lewin

Publikováno v: Journal of Virus Eradication, Vol 9, Iss 3, Pp 100345- (2023)

Introduction: Antiretroviral therapy for people living with HIV-1 must be taken lifelong due to the persistence of latent virus in long-lived and proliferating CD4+ T cells. Vitamin D3 is a steroidal gene transcription regulator which exerts diverse

Externí odkaz: https://doaj.org/article/d855402a478d4c80a0f9d2f7a2dcf56a

A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection

Autor: Eugène D.M.B. Kroon, Jintanat Ananworanich, Amélie Pagliuzza, Ajantha Rhodes, Nittaya Phanuphak, Lydie Trautmann, Julie L. Mitchell, Michelle Chintanaphol, Jintana Intasan, Suteeraporn Pinyakorn, Khuntalee Benjapornpong, J. Judy Chang, Donn J. Colby, Nitiya Chomchey, James L.K. Fletcher, Keith Eubanks, Hua Yang, John Kapson, Ashanti Dantanarayana, Surekha Tennakoon, Robert J. Gorelick, Frank Maldarelli, Merlin L. Robb, Jerome H. Kim, Serena Spudich, Nicolas Chomont, Praphan Phanuphak, Sharon R. Lewin, Mark S. de Souza

Publikováno v: Journal of Virus Eradication, Vol 6, Iss 3, Pp 100004- (2020)

Objective and Design: A randomized, open-label pilot study in individuals treated with antiretroviral therapy (ART) since acute HIV infection (AHI) with a regimen including a histone deacetylase inhibitor to induce HIV from latency and control HIV re

Externí odkaz: https://doaj.org/article/ee3fe8f6603e4421be2fb7d906475a82

Memory CD4+ T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency

Autor: Thomas A. Rasmussen, Jennifer M. Zerbato, Ajantha Rhodes, Carolin Tumpach, Ashanti Dantanarayana, James H. McMahon, Jillian S.Y. Lau, J. Judy Chang, Celine Gubser, Wendy Brown, Rebecca Hoh, Melissa Krone, Rachel Pascoe, Chris Y. Chiu, Michael Bramhall, Hyun Jae Lee, Ashraful Haque, Rèmi Fromentin, Nicolas Chomont, Jeffrey Milush, Renee M. Van der Sluis, Sarah Palmer, Steven G. Deeks, Paul U. Cameron, Vanessa Evans, Sharon R. Lewin

Publikováno v: Rasmussen, T A, Zerbato, J M, Rhodes, A, Tumpach, C, Dantanarayana, A, McMahon, J H, Lau, J S Y, Chang, J J, Gubser, C, Brown, W, Hoh, R, Krone, M, Pascoe, R, Chiu, C Y, Bramhall, M, Lee, H J, Haque, A, Fromentin, R, Chomont, N, Milush, J, Van der Sluis, R M, Palmer, S, Deeks, S G, Cameron, P U, Evans, V & Lewin, S R 2022, ' Memory CD4 + T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency ', Cell Reports Medicine, vol. 3, no. 10, 100766 . https://doi.org/10.1016/j.xcrm.2022.100766
Rasmussen, T A, Zerbato, J M, Rhodes, A, Tumpach, C, Dantanarayana, A, McMahon, J H, Lau, J S Y, Chang, J J, Gubser, C, Brown, W, Hoh, R, Krone, M, Pascoe, R, Chiu, C Y, Bramhall, M, Lee, H J, Haque, A, Fromentin, R, Chomont, N, Milush, J, Van der Sluis, R M, Palmer, S, Deeks, S G, Cameron, P U, Evans, V & Lewin, S R 2022, ' Memory CD4 + T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency. ', Cell Reports Medicine, pp. 100766 . https://doi.org/10.1016/j.xcrm.2022.100766

Programmed cell death 1 (PD1) and cytotoxic T lymphocyte-associated protein 4 (CTLA4) suppress CD4 + T cell activation and may promote latent HIV infection. By performing leukapheresis (n = 21) and lymph node biopsies (n = 8) in people with HIV on an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7eac3cf1d47dbee21076020c6ebd2c8
https://pure.au.dk/portal/da/publications/memory-cd4-tcells-that-coexpress-pd1-and-ctla4-have-reduced-response-to-activating-stimuli-facilitating-hiv-latency(d7670f1d-7904-4614-92cb-acb34e8ac600).html

Additional file 1 of Longitudinal analysis of subtype C envelope tropism for memory CD4+ T cell subsets over the first 3 years of untreated HIV-1 infection

Autor: Gartner, Matthew J., Gorry, Paul R., Tumpach, Carolin, Jingling Zhou, Dantanarayana, Ashanti, J. Judy Chang, Angelovich, Thomas A., Ellenberg, Paula, Laumaea, Annemarie E., Molati Nonyane, Moore, Penny L., Lewin, Sharon R., Churchill, Melissa J., Flynn, Jacqueline K., Roche, Michael

Additional file 1: Table S1. List of sequences and Genbank accession numbers used in this study. Table S2. Primers used to amplify and clone C-HIV Envs into pSVIII-Env. Table S3. Coreceptor usage of C-HIV Envs. Figure S1. Sequence alignments of V3 re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafc0436d3f94d261bc116d1ed9249d8

A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection

Autor: K. Eubanks, Merlin L. Robb, Jintana Intasan, Donn J Colby, Jerome H. Kim, John D. Kapson, H. Yang, James L. K. Fletcher, S. Tennakoon, Rv Study Teams, Michelle Chintanaphol, Ashanti Dantanarayana, Khuntalee Benjapornpong, Mark de Souza, Serena Spudich, Nicolas Chomont, Amélie Pagliuzza, Julie Mitchell, Robert J. Gorelick, Lydie Trautmann, Sharon R Lewin, Suteeraporn Pinyakorn, Frank Maldarelli, Nitiya Chomchey, Ajantha Rhodes, Eugene Kroon, Praphan Phanuphak, J Judy Chang, Nittaya Phanuphak, Jintanat Ananworanich

Publikováno v: Journal of Virus Eradication
Journal of Virus Eradication, Vol 6, Iss 3, Pp 100004-(2020)
Journal of virus eradication, 6(3):100004. Mediscript Ltd

Objective and Design: A randomized, open-label pilot study in individuals treated with antiretroviral therapy (ART) since acute HIV infection (AHI) with a regimen including a histone deacetylase inhibitor to induce HIV from latency and control HIV re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5572f29aee5c95d966da5b98b01087
https://pubmed.ncbi.nlm.nih.gov/33251022