Výsledky vyhledávání

A monoclonal antibody to a novel surface antigen, MKW, blocks the antiproliferative and differentiation effects of granulocyte- macrophagecolony-stimulating factor and vitamin D3

Autor: M Koehler, R Goorha, GR Kitchingman, GD Ayers, J Jr Mirro

Publikováno v: Blood. 80:367-373

A monoclonal antibody (MoAb) recognizes a novel 52-Kd cell protein (MKW) that is expressed on cells of the normal myelocytic and monocytic lineage, a subset of B cells, and the U937 cell line. Using the U937 cell line as a model, the MoAb (anti-MKW)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5931c6388e7292e92c0ac2ec337a607d
https://doi.org/10.1182/blood.v80.2.367.bloodjournal802367

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Characterization of childhood acute leukemia with multiple myeloid and lymphoid markers at diagnosis and at relapse [see comments]

Autor: CH Pui, SC Raimondi, DR Head, MJ Schell, GK Rivera, J Jr Mirro, WM Crist, FG Behm

Publikováno v: Blood. 78:1327-1337

To define the clinical and biologic significance of childhood acute mixed-lineage leukemia diagnosed by stringent criteria, we studied 25 cases of acute lymphoblastic leukemia expressing greater than or equal to 2 myeloid-associated antigens (My+ ALL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::194683b95653769e3fe75035e694a39d
https://doi.org/10.1182/blood.v78.5.1327.bloodjournal7851327

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Detection of minimal residual disease in T-cell acute lymphoblastic leukemia using polymerase chain reaction predicts impending relapse

Autor: GA Neale, J Menarguez, GR Kitchingman, TJ Fitzgerald, M Koehler, J Jr Mirro, RM Goorha

Publikováno v: Blood. 78:739-747

After achieving remission, approximately one-third of patients with T- cell acute lymphoblastic leukemia (T-ALL) relapse due to the resurgence of residual leukemic cells that cannot be detected in remission by morphologic methods. Thus, the early det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a8f569365a91eddc67cc6ce6d29af59
https://doi.org/10.1182/blood.v78.3.739.bloodjournal783739

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N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis

Autor: H P Koeffler, R Mertelsmann, F McCormick, Lübbert M, G Isaac, G Kitchingman, Carl W. Miller, J Jr Mirro, F Herrmann, J Kahan

Publikováno v: Blood. 75:1163-1169

Ras genes can be altered by point mutations at critical portions of their coding regions to acquire transforming ability in vitro. These point mutations have been detected in a variety of human malignancies. However, their relevance for the clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1499b2e37a9a86f3deb306c8ea1720f0
https://doi.org/10.1182/blood.v75.5.1163.bloodjournal7551163

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14q32 translocations are associated with mixed-lineage expression in childhood acute leukemia

Autor: Y Hayashi, CH Pui, FG Behm, AH Fuchs, SC Raimondi, GR Kitchingman, J Jr Mirro, DL Williams

Publikováno v: Blood. 76(1)

The frequency and characteristics of childhood acute leukemia with a 14q32 translocation [other than the t(8;14)(q24;q32)] were determined in 335 cases of newly diagnosed acute lymphoblastic leukemia (ALL) and 105 cases of acute nonlymphoblastic leuk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c712aa104d5d2912871738a6321a4a30
https://pubmed.ncbi.nlm.nih.gov/2364166

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Myeloid-associated antigen expression lacks prognostic value in childhood acute lymphoblastic leukemia treated with intensive multiagent chemotherapy

Autor: CH Pui, FG Behm, B Singh, GK Rivera, MJ Schell, WM Roberts, WM Crist, J Jr Mirro

Publikováno v: Blood. 75(1)

Frequency and clinical significance of myeloid-associated antigen expression in blast cells were assessed in 372 consecutive children with acute lymphoblastic leukemia (ALL). A comprehensive panel of myeloid monoclonal antibodies representing seven c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9c630835524ff5ad8cf413c8e66a74
https://pubmed.ncbi.nlm.nih.gov/2294988

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A novel treatment of childhood lymphoblastic non-Hodgkin's lymphoma: early and intermittent use of teniposide plus cytarabine

Autor: GV Dahl, G Rivera, CH Pui, J Jr Mirro, J Ochs, DK Kalwinsky, M Abromowitch, AT Look, SB Murphy

Publikováno v: Blood. 66:1110-1114

We treated 24 children and adolescents with stage III or IV lymphoblastic non-Hodgkin's lymphoma, using a protocol designed for patients with poor-prognosis acute lymphoblastic leukemia (ALL). Early therapy consisted of teniposide plus cytarabine adm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f299e48ad279cb22733efcd9b1aedf49
https://doi.org/10.1182/blood.v66.5.1110.bloodjournal6651110

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Two karyotypically independent leukemic clones with the t(8;21) and 11q23 translocation in acute myeloblastic leukemia at relapse [published erratum appears in Blood 1989 Aug 15;74(3):1180]

Autor: Y Hayashi, SC Raimondi, FG Behm, VM Santana, DK Kalwinsky, CH Pui, J Jr Mirro, DL Williams

Publikováno v: Blood. 73:1650-1655

Leukemic blast cells are thought to arise from clonal expansion of a single transformed hematopoietic cell. This generality is supported by the rarity of convincing reports on acute myeloblastic leukemia (AML) with two karyotypically independent clon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff8d1f0d77a3a78ef2ef1d9e0a7ae736
https://doi.org/10.1182/blood.v73.6.1650.bloodjournal7361650

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