Zobrazeno 1 - 10
of 1 291
pro vyhledávání: '"J John, Mann"'
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/1117be557e9046a887ec3807b35efab2
Autor:
Minlan Yuan, Biao Yang, Gerson Rothschild, J. John Mann, Larry D. Sanford, Xiangdong Tang, Canhua Huang, Chuang Wang, Wei Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-30 (2023)
Abstract Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease that affects an estimated 300 million people worldwide, but its pathogenesis is poorly understood. The heritability estimate of MDD is 30–40%, sugges
Externí odkaz:
https://doaj.org/article/72b6d04ee5ad44d9a05ab84555fabe92
Autor:
Sumra Sajid, Ryan E. Lawrence, Hanga C. Galfalvy, John G. Keilp, Vivek K. Moitra, J. John Mann, Michael F. Grunebaum
Publikováno v:
Journal of Affective Disorders Reports, Vol 15, Iss , Pp 100690- (2024)
Emergency department (ED) visits for suicidal ideation or behavior have been increasing in all age groups, particularly younger adults. A rapid-acting treatment to reduce suicidal thinking, adapted for ED use, is needed. Previous studies have shown a
Externí odkaz:
https://doaj.org/article/ea248ce368e942d3ad5e1b9f51d5f2e3
Publikováno v:
BJPsych Open, Vol 9 (2023)
We previously showed that folic acid prescriptions for any indication were associated with lower rates of suicidal behaviour. Given that future randomised clinical trials are likely to focus on psychiatric disorders carrying elevated risk for suicide
Externí odkaz:
https://doaj.org/article/bf15a56dcee744f989bd210bd7ef1596
Autor:
Jinjie Ling, John G. Keilp, Hanga C. Galfalvy, Vanessa N. Cardino, Alyina Ahmed, Ainsley K. Burke, Jenifer I. Fenton, J. John Mann, M. Elizabeth Sublette
Publikováno v:
Nutrients, Vol 15, Iss 21, p 4542 (2023)
Neurocognitive deficits are implicated in major depressive disorder (MDD) and suicidal behavior, and cognitive function may be affected by blood levels of polyunsaturated fatty acids (PUFAs). Neuroprotective functions have been described for omega-3
Externí odkaz:
https://doaj.org/article/16e7f71bf2da40e3816de92ffda0790a
Autor:
Elizabeth A. Bartlett, Ashley A. Yttredahl, Maura Boldrini, Andrea E. Tyrer, Kathryn R. Hill, Mala R. Ananth, Matthew S. Milak, Maria A. Oquendo, J. John Mann, Christine DeLorenzo, Ramin V. Parsey
Publikováno v:
European Psychiatry, Vol 66 (2023)
Abstract Background Reported childhood adversity (CA) is associated with development of depression in adulthood and predicts a more severe course of illness. Although elevated serotonin 1A receptor (5-HT1AR) binding potential, especially in the raph
Externí odkaz:
https://doaj.org/article/0beaf2f9876840caa8cc2123d1a16faf
Autor:
Na Luo, Ioanna Mosialou, Mattia Capulli, Brygida Bisikirska, Chyuan-Sheng Lin, Yung-yu Huang, Peter T. Shyu, X. Edward Guo, Aris Economides, J. John Mann, Stavroula Kousteni
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
The various functions of the skeleton are influenced by extracellular cues, hormones, and neurotransmitters. One type of neuronal regulation favors bone mass accrual by inhibiting sympathetic nervous system (SNS) activity. This observation raises que
Externí odkaz:
https://doaj.org/article/b9e861080b4a4c4f82712f46ce3a089e
Autor:
Kelly Smart, Ashley Yttredahl, Maria A. Oquendo, J. John Mann, Ansel T. Hillmer, Richard E. Carson, Jeffrey M. Miller
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Preclinical studies have implicated kappa opioid receptors (KORs) in stress responses and depression-related behaviors, but evidence from human studies is limited. Here we present results of a secondary analysis of data acquired using positr
Externí odkaz:
https://doaj.org/article/441a7b9029424e3c8bf9ec359a4e5342
Autor:
Joshua T. Kantrowitz, Zhengchao Dong, Matthew S. Milak, Rain Rashid, Lawrence S. Kegeles, Daniel C. Javitt, Jeffrey A. Lieberman, J. John Mann
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-6 (2021)
Abstract Glutamate (Glu) and gamma-aminobutyric acid (GABA) are implicated in the pathophysiology of major depressive disorder (MDD). GABA levels or GABAergic interneuron numbers are generally low in MDD, potentially disinhibiting Glu release. It is
Externí odkaz:
https://doaj.org/article/45785de8c5354a3caf6214437af79f9f
Autor:
Muhammad Imran Qadeer, Ali Amar, Yung-Yu Huang, Eli Min, Hanga Galfalvy, Shahida Hasnain, J. John Mann
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The serotonin transporter (SLC6A4), 5-HT2A (HTR2A) and 5-HT2B (HTR2B) recepter genes, express proteins that are important regulators of serotonin reuptake and signaling, and thereby may contribute to the pathogenesis of aggressive criminal b
Externí odkaz:
https://doaj.org/article/0b7efe7db0a2463085455826f10fa6c2