Zobrazeno 1 - 10
of 36
pro vyhledávání: '"J J de Pont"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1109:17-32
Covalent linkage of ethylenediamine with the Na + /K + -ATPase complex from rabbit kidney outer medulla by the use of the water-soluble carbodiimide, N -ethyl, N ′-(3-dimethylaminopropyl)carbodiimide, resulted in a 73% reaction with phosphatidylser
Publikováno v:
The Journal of biological chemistry. 276(40)
Several mutations of residues Glu(795) and Glu(820) present in M5 and M6 of the catalytic subunit of gastric H(+),K(+)-ATPase have resulted in a K(+)-independent, SCH 28080-sensitive ATPase activity, caused by a high spontaneous dephosphorylation rat
Publikováno v:
The Journal of biological chemistry. 276(15)
In this study we reveal regions of Na(+),K(+)-ATPase and H(+),K(+)-ATPase that are involved in cation selectivity. A chimeric enzyme in which transmembrane hairpin M5-M6 of H(+),K(+)-ATPase was replaced by that of Na(+),K(+)-ATPase was phosphorylated
Autor:
L.P.W.J. van den Heuvel, J J de Pont, Jan B. Koenderink, Leo A. H. Monnens, H Van Bokhoven, K.F.H. Assink, Iwan C. Meij, René J. M. Bindels, Nine V A M Knoers, Wouter M. Tiel Groenestege
Publikováno v:
Nature Genetics, 26, 265-266
Nature Genetics, 26, pp. 265-266
Nature Genetics, 26, pp. 265-266
Primary hypomagnesaemia is composed of a heterogeneous group of disorders characterized by renal or intestinal Mg(2+) wasting, often associated with disturbances in Ca(2+) excretion. We identified a putative dominant-negative mutation in the gene enc
Autor:
R L, Smeets, M A, Fouraux, W, Pouwels, S E, van Emst-de Vries, E, Ronken, J J, De Pont, P H, Willems
Publikováno v:
British journal of pharmacology. 124(5)
1. Many G protein-coupled receptors contain potential phosphorylation sites for protein kinase C (PKC), the exact role of which is poorly understood. In the present study, a mutant cholecystokininA (CCK(A)) receptor was generated in which the four co
Publikováno v:
European journal of clinical investigation. 28(5)
In this review the usefulness of the measurement of erythrocyte Na+/Li+ countertransport (Na+/Li+ CT) activity is evaluated. In particular, the association between enhanced erythrocyte Na+/Li+ CT activity and essential hypertension, hyperlipidaemia a
Protein kinase C-mediated inhibition of transmembrane signalling through CCK(A) and CCK(B) receptors
Publikováno v:
British journal of pharmacology. 123(6)
1. The rat CCK(A) and CCK(B) receptors were stably expressed in Chinese hamster ovary (CHO-09) cells in order to compare modes of signal transduction and effects of protein kinase C (PKC) thereupon. 2. Spectrofluorophotometry of Fura-2-loaded cells r
Publikováno v:
Gut. 35(11)
To evaluate whether the general trophic effect of gastrin on the oxyntic mucosa is an indirect effect mediated by histamine H2 receptors, sustained 24 hour hypergastrinaemia was induced in Sprague-Dawley rats by treatment with the long acting and pot
Publikováno v:
The Journal of biological chemistry. 269(17)
Permeabilized rabbit pancreatic acinar cells were used to study the effects of Ca2+ pump inhibition and Ca2+ store depletion on the sensitivity of internal Ca2+ stores to emptying by inositol 1,4,5-trisphosphate (Ins-1,4,5-P3). Complete inhibition of
Autor:
I F, de Coo, F J, Gabreëls, W O, Renier, J J, de Pont, U J, van Haelst, J H, Veerkamp, J M, Trijbels, H H, Jaspar, K, Renkawek
Publikováno v:
Clinical neuropathology. 10(2)
In this study we present a patient with Canavan disease or Van Bogaert and Bertrand type of spongiform leukodystrophy, proven by brain biopsy. We performed morphological studies and biochemical assays on fresh homogenates of the grey and white matter