Výsledky vyhledávání

Allelic variation in the mouse Tap-1 and Tap-2 transporter genes

Autor: K Marusina, M Iyer, J J Monaco

Publikováno v: The Journal of Immunology. 158:5251-5256

The TAP1 and TAP2 proteins form a heterodimer that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Extensive allelic polymorphism of the rat TAP transporter has been shown to affect the repertoire of peptides presente

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4509a4bbd1666a647ea02d4de69afe87
https://doi.org/10.4049/jimmunol.158.11.5251

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Interferon-gamma independently activates the MHC class I antigen processing pathway and diminishes glucose responsiveness in pancreatic beta-cell lines

Autor: M. E. Baldeon, D. J. Neece, D. Nandi, J. J. Monaco, H. R. Gaskins

Publikováno v: Diabetes. 46:770-778

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::102895488d0b9cfcdcbcc4c1723dd108
https://doi.org/10.2337/diabetes.46.5.770

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Identification of MECL-1 (LMP-10) as the third IFN-gamma-inducible proteasome subunit

Autor: D Nandi, H Jiang, J J Monaco

Publikováno v: The Journal of Immunology. 156:2361-2364

We show that six proteasome-associated proteins are induced by IFN-gamma, corresponding to three proteasome beta-type subunits and their precursors: the MHC-linked subunits (LMP-2 and LMP-7) and LMP-10. Concurrently, incorporation of LMP-9, LMP-17, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44a40aa365a5aa421a47b2d6f972aa28
https://doi.org/10.4049/jimmunol.156.7.2361

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T cell recognition of QA-1b antigens on cells lacking a functional Tap-2 transporter

Autor: C J Aldrich, R Waltrip, E Hermel, M Attaya, K F Lindahl, J J Monaco, J Forman

Publikováno v: The Journal of Immunology. 149:3773-3777

MHC class Ia H chains and beta 2-microglobulin assemble with appropriate peptides to form stable cell surface molecules that serve as targets for Ag-specific CTL. The structural similarities of class Ia and the less polymorphic Q/T/M (class Ib) molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9b7ae80daa82113de68bf6f18fb9603
https://doi.org/10.4049/jimmunol.149.12.3773

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Burn injury upregulates the activity and gene expression of the 20 S proteasome in rat skeletal muscle

Autor: C H, Fang, B G, Li, D R, Fischer, J J, Wang, H A, Runnels, J J, Monaco, P O, Hasselgren

Publikováno v: Clinical science (London, England : 1979). 99(3)

There is evidence that burn injury stimulates ubiquitin-proteasome-dependent protein breakdown in skeletal muscle. In this proteolytic pathway, protein substrates are conjugated to multiple molecules of ubiquitin, whereafter they are recognized, unfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6187b1e86231776962b1c7c72de93cff
https://pubmed.ncbi.nlm.nih.gov/11787469

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Purification of 20S proteasomes

Autor: J R, Beyette, T, Hubbell, J J, Monaco

Publikováno v: Methods in molecular biology (Clifton, N.J.). 156

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec9e0da7ea606391fdc96e016c36017c
https://pubmed.ncbi.nlm.nih.gov/11068746

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Class II antigen processing defects in two H2d mouse cell lines are caused by point mutations in the H2-DMa gene

Autor: H I, Russell, I A, York, K L, Rock, J J, Monaco

Publikováno v: European journal of immunology. 29(3)

The molecular nature of the defect in two mouse antigen processing-defective cell lines was examined. Both mutants were derived from the A20 (BALB/c, H2d) B cell line, and both were found to have defects in the H2-DMa gene. Mutant 3A5 exhibits severe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd91a1ae3b94c9b80db473aa0c86fada
https://pubmed.ncbi.nlm.nih.gov/10092094

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Antigen processing of two H2-IEd-restricted epitopes is differentially influenced by the structural changes in a viral glycoprotein

Autor: K A, Chianese-Bullock, H I, Russell, C, Moller, W, Gerhard, J J, Monaco, L C, Eisenlohr

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(4)

The factors that influence the intracellular location(s) of MHC class II-restricted epitope loading remain poorly understood. We present evidence that two I-Ed-restricted epitopes of the influenza hemagglutinin (HA) molecule, termed site 1 (S1; encom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8c4dad9fb9f9bf4752c760953161db3
https://pubmed.ncbi.nlm.nih.gov/9712021

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How do endogenous proteins become peptides and reach the endoplasmic reticulum

Autor: D, Nandi, K, Marusina, J J, Monaco

Publikováno v: Current topics in microbiology and immunology. 232

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca3ebdbff18b98777a289b63d9bc21e2
https://pubmed.ncbi.nlm.nih.gov/9557392

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Molecular and serological analysis of polymorphisms in the murine major histocompatibility complex-encoded proteasome subunits, LMP-2 and LMP-7

Autor: D, Nandi, M N, Iyer, J J, Monaco

Publikováno v: Experimental and clinical immunogenetics. 13(1)

LMP-2 and LMP-7, gamma-interferon-inducible subunits of the 20S proteasome, play an important role in antigen processing. To define the molecular basis of their polymorphism, we sequenced Lmp-2 and Lmp-7 cDNA from nine different strains of mice. Thre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c3dd9ad312dc0683ec288070abbc44df
https://pubmed.ncbi.nlm.nih.gov/8854085

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