Zobrazeno 1 - 10
of 59
pro vyhledávání: '"J J Kopchick"'
Publikováno v:
Journal of Molecular Endocrinology. 19:1-13
In murine species, the GH receptor (mGHR) gene encodes a full-length membrane-anchored mGHR and a truncated soluble receptor ectodomain (the GH-binding protein; mGHBP). The mGHR and mGHBP mRNAs are generated by alternative pre-mRNA splicing. Similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899fa97c18ef5ae522b2a9962669cb0a
https://doi.org/10.1677/jme.0.0190001
https://doi.org/10.1677/jme.0.0190001
Autor:
I. C. A. F. Robinson, W. Y. Chen, J. J. Kopchick, Timothy N. C. Wells, R. G. Clark, P. Tollet, D. F. Carmignac, Agneta Mode
Publikováno v:
Scopus-Elsevier
Human GH (hGH) acts by dimerizing two hGH receptors that bind to different sites in hGH. G120RhGH, an analog mutated in the second binding site to prevent receptor dimerization, acts as an antagonist in vitro. We have now tested the activity of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4598aa8755abbb32313a603031984e
https://doi.org/10.1210/endo.137.2.8593788
https://doi.org/10.1210/endo.137.2.8593788
Autor:
A, Jara, J J, Kopchick
Publikováno v:
Anales de pediatria (Barcelona, Spain : 2003). 78(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d9c7b7292fd7b8329a6f392fe2cb427c
https://pubmed.ncbi.nlm.nih.gov/23265721
https://pubmed.ncbi.nlm.nih.gov/23265721
Autor:
J J, Kopchick
Publikováno v:
Journal of endocrinological investigation. 26
In attempting to understand the structure of the GH molecule and its function(s), we found that 1 amino acid, glycine, in the third alpha-helix of GH (Gly119 of bovine GH and Gly120 of human GH) was important for biologic activity. Substitution of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c393f2972ae73a9c357e454ccaf207b2
https://pubmed.ncbi.nlm.nih.gov/15497656
https://pubmed.ncbi.nlm.nih.gov/15497656
Publikováno v:
Biogerontology. 4(1)
Insulin/insulin-like growth factor (IGF) signaling plays a major role in the control of aging and life span in invertebrates. Major extension of life span in growth hormone receptor knock out (GHR-KO) mice that are GH resistant, and subsequently, IGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c4ad2a9faa183e1145abfba43d14b3f0
https://pubmed.ncbi.nlm.nih.gov/12652183
https://pubmed.ncbi.nlm.nih.gov/12652183
Autor:
D T, Kohn, J-J, Kopchick
Publikováno v:
Minerva endocrinologica. 27(4)
Growth hormone (GH) has profound effects on vertebrate growth and cellular differentiation in diverse tissue types. Sexually dimorphic levels of circulating GH vary during development and throughout the lifespan. The synthesis and secretion of GH by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f1cb10402e4568442d5795dbfc57596c
https://pubmed.ncbi.nlm.nih.gov/12511851
https://pubmed.ncbi.nlm.nih.gov/12511851
Publikováno v:
Endocrinology. 141(7)
GH has many biological roles, including promotion of growth. Most, if not all, of its roles are achieved through interaction with its receptor. We chose to study the effects of loss of GH signaling on growth and aging in a mouse model for Laron Syndr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::199de557dac67fc1526104eb7432d6c3
https://pubmed.ncbi.nlm.nih.gov/10875265
https://pubmed.ncbi.nlm.nih.gov/10875265
Autor:
A E, Leonard, B, Kelder, E G, Bobik, L T, Chuang, J M, Parker-Barnes, J M, Thurmond, P E, Kroeger, J J, Kopchick, Y S, Huang, P, Mukerji
Publikováno v:
The Biochemical journal.
Two human expressed sequence tag (EST) cDNA sequences with identity with Delta(5)- and Delta(6)-desaturases from a filamentous fungus, Mortierella alpina, were identified from the LifeSeq(R) database of Incyte Pharmaceuticals, Inc. (Palo Alto, CA, U.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5998b62be2bf987e52ffa9898995c44c
https://pubmed.ncbi.nlm.nih.gov/10769175
https://pubmed.ncbi.nlm.nih.gov/10769175
Publikováno v:
Endocrinology. 141(1)
To further investigate the role of GH in diabetic nephropathy, experimental diabetes was induced with streptozotocin (STZ) in mice in which the GH receptor/binding protein gene was disrupted. Body weight, blood glucose, and renal histology and morpho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9820f9e36da30a7bd555b932f5e733b5
https://pubmed.ncbi.nlm.nih.gov/10614635
https://pubmed.ncbi.nlm.nih.gov/10614635