From Reactive to Proactive - The Future Life Design to Promote Health and Extend the Human Lifespan.

Autor: Yao L; College of Health management, Harbin Medical University, 157 Baojian Road, Harbin, Heilongjiang, 150081, China.; Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, 38163, USA., Yang C; Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, 38163, USA., Graff JC; Department of Health Promotion and Disease Prevention, College of Nursing, University of Tennessee Health Science Center, Memphis, TN, 38163, USA., Wang G; Department of General Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China., Wang G; Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150007, China.; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150007, China., Gu W; Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.; Research Service, Memphis VA Medical Center, 1030 Jefferson Avenue, Memphis, TN, 38104, USA.; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 881 Madison Ave, Memphis, TN, 38163, USA.

Publikováno v: Advanced biology [Adv Biol (Weinh)] 2024 Oct; Vol. 8 (10), pp. e2400148. Date of Electronic Publication: 2024 Jul 22.

The human growth hormone (hGH) antagonist G120RhGH does not antagonize GH in the rat, but has paradoxical agonist activity, probably via the prolactin receptor

Autor: I. C. A. F. Robinson, W. Y. Chen, J. J. Kopchick, Timothy N. C. Wells, R. G. Clark, P. Tollet, D. F. Carmignac, Agneta Mode

Publikováno v: Scopus-Elsevier

Human GH (hGH) acts by dimerizing two hGH receptors that bind to different sites in hGH. G120RhGH, an analog mutated in the second binding site to prevent receptor dimerization, acts as an antagonist in vitro. We have now tested the activity of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4598aa8755abbb32313a603031984e
https://doi.org/10.1210/endo.137.2.8593788

Human Serum Biomarkers for Detection of Erythropoietin Action

Autor: B Christensen, L Sackmann-Sala, D Cruz-Topete, J O L Jorgensen, N Jessen, C Lundby, J J Kopchick

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1237faf781f41adf0c41f51145e726a8
https://doi.org/10.1210/endo-meetings.2010.part2.p3.p2-135

Insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights

Autor: A, Bartke, V, Chandrashekar, F, Dominici, D, Turyn, B, Kinney, R, Steger, J J, Kopchick

Publikováno v: Biogerontology. 4(1)

Insulin/insulin-like growth factor (IGF) signaling plays a major role in the control of aging and life span in invertebrates. Major extension of life span in growth hormone receptor knock out (GHR-KO) mice that are GH resistant, and subsequently, IGF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c4ad2a9faa183e1145abfba43d14b3f0
https://pubmed.ncbi.nlm.nih.gov/12652183

Assessment of growth parameters and life span of GHR/BP gene-disrupted mice

Autor: K T, Coschigano, D, Clemmons, L L, Bellush, J J, Kopchick

Publikováno v: Endocrinology. 141(7)

GH has many biological roles, including promotion of growth. Most, if not all, of its roles are achieved through interaction with its receptor. We chose to study the effects of loss of GH signaling on growth and aging in a mouse model for Laron Syndr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::199de557dac67fc1526104eb7432d6c3
https://pubmed.ncbi.nlm.nih.gov/10875265