Zobrazeno 1 - 10
of 23
pro vyhledávání: '"J J, Turchi"'
Autor:
J J, Turchi
Publikováno v:
Methods in molecular medicine. 39
Programmed cell death or apoptosis can be induced by a variety of mechanisms including genotoxic stress (1-3). The initiation of apoptosis involves the activation of a proteolytic cascade reminiscent of the blood-clotting pathway or activation of pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fe235b366872de0733778087cee7e3c
https://pubmed.ncbi.nlm.nih.gov/21340832
https://pubmed.ncbi.nlm.nih.gov/21340832
Autor:
S M, Patrick, J J, Turchi
Publikováno v:
The Journal of biological chemistry. 276(25)
Replication protein A (RPA) is a heterotrimeric protein required for many DNA metabolic functions, including replication, recombination, and nucleotide excision repair (NER). We report the pre-steady-state kinetic analysis of RPA-binding DNA substrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28916d23ed7d896d9e206b6a71017add
https://pubmed.ncbi.nlm.nih.gov/11278662
https://pubmed.ncbi.nlm.nih.gov/11278662
Autor:
J J, Turchi, M, Ho
Publikováno v:
EXS. 89
Protein kinases are key regulatory enzymes involved in a multitude of biochemical pathways. This chapter will describe the current research on targeting specific protein kinases with inhibitors in attempts to disrupt flux through specific pathways. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62090087a5e886176d350ba700a6e071
https://pubmed.ncbi.nlm.nih.gov/10997285
https://pubmed.ncbi.nlm.nih.gov/10997285
Autor:
K M, Henkels, J J, Turchi
Publikováno v:
Cancer research. 59(13)
We have assessed in detail the effect of cisplatin-activated programmed cell death in the cisplatin-sensitive human ovarian cancer cell line A2780 and two drug-resistant subclones, CP70 and C30. To determine whether the differential extent of apoptos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5a69a39271e69036a411706d98565c5
https://pubmed.ncbi.nlm.nih.gov/10397248
https://pubmed.ncbi.nlm.nih.gov/10397248
Publikováno v:
Cancer research. 57(22)
In response to genotoxic stress, the p53 tumor suppressor protein exerts a G1 cell cycle arrest that is dependent on its ability to transactivate downstream target genes. This p53-dependent G1 block is reversed by the binding of Mdm-2 to p53, prevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::926c1e294368d3db134f567351e152ca
https://pubmed.ncbi.nlm.nih.gov/9371494
https://pubmed.ncbi.nlm.nih.gov/9371494
Autor:
K M, Henkels, J J, Turchi
Publikováno v:
Cancer research. 57(20)
In this study, we have assessed the mechanism of cytotoxicity in a series of cisplatin-sensitive and -resistant ovarian carcinoma cells following treatment with equitoxic concentrations of cisplatin. The specific proteolytic degradation and the enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30f83b9aa57921c8ee95c0f82f5c92a3
https://pubmed.ncbi.nlm.nih.gov/9377558
https://pubmed.ncbi.nlm.nih.gov/9377558
Publikováno v:
The Journal of biological chemistry. 269(41)
Cleavage specificity of RNase HI was examined on model Okazaki fragments, to determine the likely role of this nuclease in lagging strand DNA replication. Each substrate was prepared by annealing a short RNA primer, made by transcription in vitro, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2290961d90a4471f1983d5163c98bd92
https://pubmed.ncbi.nlm.nih.gov/7523396
https://pubmed.ncbi.nlm.nih.gov/7523396
Publikováno v:
The Journal of biological chemistry. 269(2)
The catalytic activity of the calf thymus 5'- to 3'-exonuclease was measured on substrates consisting of two primers annealed adjacent to each other on a template. Exonucleolytic degradation of the downstream primer is very slow if the primers are se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4390000d3b086e3c2eff51489a98d941
https://pubmed.ncbi.nlm.nih.gov/8288581
https://pubmed.ncbi.nlm.nih.gov/8288581
Publikováno v:
The Journal of biological chemistry. 268(35)
Calf DNA helicase E (hel E) is a moderately processive, 3' to 5' helicase, active on nicked DNA, that we have proposed to have a role in DNA repair (Turchi, J. J., Murante, R. S., and Bambara, R. A. (1992) Nucleic Acids Res. 20, 6075-6080). Here we h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb66887d7a11237f88b71e1473b4926c
https://pubmed.ncbi.nlm.nih.gov/8253808
https://pubmed.ncbi.nlm.nih.gov/8253808
Autor:
J J, Turchi, R A, Bambara
Publikováno v:
The Journal of biological chemistry. 268(20)
We have modeled the reactions involved in the completion of lagging strand DNA replication using a synthetic DNA substrate and purified enzymes from calf thymus. We have demonstrated that each polymerase, alpha, delta, and epsilon, is capable of exte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ff0c76d9af056c0ae7c1216ef40f650
https://pubmed.ncbi.nlm.nih.gov/8392066
https://pubmed.ncbi.nlm.nih.gov/8392066