Zobrazeno 1 - 10
of 42
pro vyhledávání: '"J J, Starling"'
Autor:
N, Suh, A L, Glasebrook, A D, Palkowitz, H U, Bryant, L L, Burris, J J, Starling, H L, Pearce, C, Williams, C, Peer, Y, Wang, M B, Sporn
Publikováno v:
Cancer research. 61(23)
Arzoxifene ([6-hydroxy-3-[4-[2-(1-piperidinyl)-ethoxy]phenoxy]-2-(4-methoxyphenyl)]benzo[b]thiophene) is a selective estrogen receptor modulator (SERM) that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen ago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::24086254f36ab915ef7a017b0e76a352
https://pubmed.ncbi.nlm.nih.gov/11731420
https://pubmed.ncbi.nlm.nih.gov/11731420
Publikováno v:
Current medicinal chemistry. 8(1)
Multidrug resistance may be conferred by P-glycoprotein (Pgp, ABCB1) or the multidrug resistance associated protein (MRP). These membrane proteins are members of the ATP binding cassette transporter superfamily and are responsible for the removal fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fac236d2c622044774e3d2785f48c2b
https://pubmed.ncbi.nlm.nih.gov/11172691
https://pubmed.ncbi.nlm.nih.gov/11172691
Autor:
A H, Dantzig, R L, Shepard, K L, Law, L, Tabas, S, Pratt, J S, Gillespie, S N, Binkley, M T, Kuhfeld, J J, Starling, S A, Wrighton
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(2)
Overexpression of ATP-dependent drug efflux pumps, P-glycoprotein (Pgp) or multidrug resistance-associated protein (MRP), confers multidrug resistance to tumor cells. Modulators of multidrug resistance block the action of these pumps, thereby sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d646c368d025c93a9c45d37b8ae7a0e
https://pubmed.ncbi.nlm.nih.gov/10411602
https://pubmed.ncbi.nlm.nih.gov/10411602
Autor:
A H, Dantzig, R L, Shepard, J, Cao, K L, Law, W J, Ehlhardt, T M, Baughman, T F, Bumol, J J, Starling
Publikováno v:
Cancer research. 56(18)
Overexpression of P-glycoprotein (Pgp) by tumors results in multidrug resistance (MDR) to structurally unrelated oncolytics. MDR cells may be sensitized to these oncolytics when treated with a Pgp modulator. The present study evaluates LY335979 as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0aebe6542116121920b73ee25223acb8
https://pubmed.ncbi.nlm.nih.gov/8797588
https://pubmed.ncbi.nlm.nih.gov/8797588
Autor:
V F, Patel, J N, Hardin, J M, Mastro, K L, Law, J L, Zimmermann, W J, Ehlhardt, J M, Woodland, J J, Starling
Publikováno v:
Bioconjugate chemistry. 7(4)
LY207702 (1) is a difluorinated purine nucleoside that exhibits impressive antitumor activity in preclinical models. This agent, however, also possesses cardiotoxicity which limits the potential clinical utility of this novel drug candidate. We there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::35f01e2422c3f9bb01d940d8dc0d4092
https://pubmed.ncbi.nlm.nih.gov/8853464
https://pubmed.ncbi.nlm.nih.gov/8853464
Publikováno v:
Anticancer research. 14(3A)
Well established UCLA-P3 human lung tumor xenografts were significantly regressed by treatment with a monoclonal antibody-vinca immunoconjugate whereas no regressions were observed for the LS174T and SW948 human colon carcinoma xenografts by this the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7472e8f84c1d81fc0b2a01f38b82e65e
https://pubmed.ncbi.nlm.nih.gov/7915508
https://pubmed.ncbi.nlm.nih.gov/7915508
Publikováno v:
Cancer research. 51(11)
It is widely believed that antigen heterogeneity and noninternalization of antigen-antibody complexes will severely limit the antitumor activity of monoclonal antibody-drug conjugates. The B72.3 monoclonal antibody binds to a tumor-associated antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bda2c45aafea02926a46962fd66e3471
https://pubmed.ncbi.nlm.nih.gov/2032233
https://pubmed.ncbi.nlm.nih.gov/2032233
Autor:
J J, Starling, R S, Maciak, N A, Hinson, J, Hoskins, B C, Laguzza, R A, Gadski, J, Strnad, L, Rittmann-Grauer, S V, DeHerdt, T F, Bumol
Publikováno v:
Cancer research. 50(23)
UCLA-P3 human lung adenocarcinoma cells were grown in nude mice and given repetitive treatments of a monoclonal antibody-Vinca alkaloid immunoconjugate. Although this therapy resulted in a greater than 4-fold reduction in mean tumor mass of the estab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::483884a7b612f747f01acc74b610db34
https://pubmed.ncbi.nlm.nih.gov/1979247
https://pubmed.ncbi.nlm.nih.gov/1979247
Publikováno v:
The Prostate. 3:203-214
Antibodies against a soluble cytoplasmic protein contained in prostate epithelial cells were developed using the hybridoma technique. This was done to provide markers for these cells that can be used to identify acinar cells in culture and to follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4acc3f470c447869b03fbd76e30002a4
https://doi.org/10.1002/pros.2990030212
https://doi.org/10.1002/pros.2990030212
Publikováno v:
The Prostate. 6:205-215
Virological and epidemiological studies have implicated human cytomegalovirus (HCMV) as a possible etiological agent of prostate cancer. Because of the suspected associations, this laboratory tested the reactivity of a prostate-associated monoclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cc3d54822dd9aaca23c1309d75ba40
https://doi.org/10.1002/pros.2990060211
https://doi.org/10.1002/pros.2990060211