Zobrazeno 1 - 10
of 66
pro vyhledávání: '"J J, Sramek"'
Publikováno v:
Acta Neurologica Scandinavica. 97:244-250
This study evaluates the activity of SDZ ENA 713, a centrally-selective acetylcholinesterase (AChE) inhibitor, in the cerebral spinal fluid (CSF) of patients with Alzheimer's disease (AD), and its relationship to central and peripheral pharmacokineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cafb5bdff0bc36ea64a14687e8a1e6
https://doi.org/10.1111/j.1600-0404.1998.tb00645.x
https://doi.org/10.1111/j.1600-0404.1998.tb00645.x
Autor:
W S Mullican, B Levy, M T Leibowitz, P D Toth, J J Sramek, N R Cutler, C M Mendel, F G McMahon, E. Rowe, S P Weinstein
Publikováno v:
Journal of Human Hypertension. 16:13-19
Sibutramine is a serotonin-noradrenaline reuptake inhibitor that is effective for long-term weight reduction and maintenance in obese patients when used as an adjunct to dietary and behavioural measures. Because the inhibition of noradrenaline reupta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137a99ee3228324595bb54793407d88c
https://doi.org/10.1038/sj.jhh.1001299
https://doi.org/10.1038/sj.jhh.1001299
Autor:
G. Block, Scott A. Reines, T.V. Olah, D Panebianco, H. Cheng, N. R. Cutler, J. Claghorn, J J Sramek
Publikováno v:
Cephalalgia. 16:113-116
MK-462 is a potent, selective 5HT1D receptor agonist which may be useful in treating acute migraine. We conducted a double-blind placebo-controlled inpatient study to assess the preliminary efficacy and safety of oral doses of MK-462 20 mg ( n = 8) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a72ff5c1b6ececbb50d57c08e76805
https://doi.org/10.1046/j.1468-2982.1996.1602113.x
https://doi.org/10.1046/j.1468-2982.1996.1602113.x
Autor:
J. P. Hubble, J J Sramek, Joseph H. Friedman, A Elvin, D Korts, N R Cutler, William C. Koller, Christopher G. Goetz, A Ranhosky
Publikováno v:
Clinical Neuropharmacology. 18:338-347
We evaluated the efficacy, safety, tolerability, and pharmacokinetics of pramipexole, a novel dopamine D2 receptor agonist, in early Parkinson's disease (PD). The study design was a parallel, placebo-controlled trial using an ascending dose of 4.5 mg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ced997c7b91fafd35e24acbf381490
https://doi.org/10.1097/00002826-199508000-00006
https://doi.org/10.1097/00002826-199508000-00006
Autor:
N R, Cutler, J J, Sramek
Publikováno v:
Journal of clinical pharmacology. 40(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4f767864b717cbb7a65b7da11db0637
https://pubmed.ncbi.nlm.nih.gov/11075302
https://pubmed.ncbi.nlm.nih.gov/11075302
Autor:
J J, Sramek, S, Kirkesseli, A, Paccaly-Moulin, J, Davidson, S S, Jhee, J, Hourani, D, Sémiond, N R, Cutler
Publikováno v:
Psychopharmacology bulletin. 34(4)
Fananserin is a potential antipsychotic compound with high affinity for both D4 and 5-HT2A receptors, and negligible affinity for D2 receptors. Because the tolerance for antipsychotic compounds often differs between schizophrenic patients and healthy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a3a9656fd99c9c70b138a5cadd6837b
https://pubmed.ncbi.nlm.nih.gov/10513457
https://pubmed.ncbi.nlm.nih.gov/10513457
Publikováno v:
Depression and anxiety. 9(3)
Buspirone is an azapirone with 5-HT1A partial agonist activity which has demonstrated efficacy in the treatment of generalized anxiety disorder, commonly referred to as persistent anxiety. In this meta-analysis report, safety results from two studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31c2bd686f78d5bb49cab2b224431571
https://pubmed.ncbi.nlm.nih.gov/10356651
https://pubmed.ncbi.nlm.nih.gov/10356651
Autor:
N R, Cutler, J J, Sramek
Publikováno v:
Revue neurologique. 154
The process of drug development involves cycles of learning and confirming. In the learning phase of the cycle, data from studies are used to generate hypotheses; later studies are designed specifically to confirm these hypotheses. There is a growing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::032d6b153194c68bf6dde0783d118f21
https://pubmed.ncbi.nlm.nih.gov/9834554
https://pubmed.ncbi.nlm.nih.gov/9834554
Publikováno v:
Depression and anxiety. 5(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2155f738cf546e6fae911af02c4c2745
https://pubmed.ncbi.nlm.nih.gov/9323457
https://pubmed.ncbi.nlm.nih.gov/9323457
Autor:
J J, Sramek, E H, Pi
Publikováno v:
The Mount Sinai journal of medicine, New York. 63(5-6)
Modern psychopharmacology provides us with several effective antidepressants. We are increasingly recognizing the importance of interindividual differences in plasma concentration with these drugs. Such differences are caused by genetics, and the mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce0cdb6236871517121da235ee919523
https://pubmed.ncbi.nlm.nih.gov/8898535
https://pubmed.ncbi.nlm.nih.gov/8898535