Zobrazeno 1 - 10
of 13
pro vyhledávání: '"J J, Rady"'
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. 224:93-101
Heroin produced antinociception in the tail flick test through mu receptors in the brain of ICR and CD-1 mice, a response inhibited by 3-O-methylnaltrexone. Tolerance to morphine was produced by subcutaneous morphine pellet implantation. By the third
Publikováno v:
Experimental Biology and Medicine. 220:178-183
Autor:
J J, Rady, J M, Fujimoto
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(2)
Spinal dynorphin A(1-17) (Dyn) has been shown previously to produce an antianalgesic action against intrathecal morphine in the tail-flick test in CD-1 mice. This action is known to be mediated indirectly from the spinal cord through an afferent path
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 297(2)
Dynorphin A(1-17) given intrathecally releases spinal cholecystokinin to produce an antianalgesic action against spinal morphine in the tail-flick test in CD-1 mice. The present study showed that following the cholecystokinin step, a delta(2)-opioid
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(1)
An antianalgesic action of intracerebroventricularly administered nociceptin was elicited against intrathecal morphine-induced antinociception in the tail-flick test in mice and investigated as a descending neuronal system for the spinal mediator inv
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(2)
Heroin administered i.c.v. acts on supraspinal mu opioid receptors in ICR mice but on delta receptors in Swiss Webster mice. The purpose of this study was to determine the degree to which genotype plays a role in the opioid receptor selectivity of he
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 284(3)
Pentobarbital administered intracerebroventricularly to mice has been shown previously to inhibit the analgesic action of morphine given intrathecally. The purpose of the present study was to examine the proposal that this antianalgesic action was me
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 268(3)
Heroin activates delta receptors, whereas morphine activates mu receptors, in the brain of Swiss-Webster mice, to produce antinociception. The present study determined the type of opioid receptor activated by 6-monoacetylmorphine (MAM), a metabolite
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 268(2)
Previous studies in mice demonstrate that, when dynorphin A (1-17) (Dyn A) is administered intrathecally (i.t.) or released spinally (by administration of clonidine or midazolam i.c.v.), i.t. morphine-induced analgesia was reduced. The present aim wa
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 259(3)
In recent publications we have proposed that dynorphin (Dyn) A(1-17) functions as an antianalgesic modulator to oppose opioid-induced antinociception in mice. In the present experiments using the tail-flick response in mice, other Dyns [Dyn A(1-8), D