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Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor

Autor: T, Kawai, H, Sogawa, M, Koulmanda, R N, Smith, J J, O'Neil, S L, Wee, S, Boskovic, M, Sykes, R B, Colvin, D H, Sachs, H, Auchincloss, A B, Cosimi, D S, C Ko

Publikováno v: Transplantation. 72(2)

Development of mixed chimerism by donor bone marrow transplantation (DBMT) has led to long-term tolerance of solid organ allografts in nonhuman primates. As an initial attempt to extend this approach to cellular transplant, islet transplant from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e111a5b58e1c84bb431b3d5ec6372911
https://pubmed.ncbi.nlm.nih.gov/11477369

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Increase in beta-cell mass in transplanted porcine neonatal pancreatic cell clusters is due to proliferation of beta-cells and differentiation of duct cells

Autor: Susan Bonner-Weir, M. D. López-Avalos, M. Keegan, J. J. O’Neil, Gordon C. Weir, Jennifer Hollister-Lock, Nitin Trivedi

Publikováno v: Endocrinology. 142(5)

A 20-fold increase in β-cell mass has been found after transplantation of porcine neonatal pancreatic cell clusters (NPCCs). Here the mechanisms leading to this increased β-cell mass were studied. NPCCs (4000 islet equivalents) generated after 8 da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b43ffdea0c4e6c6c25e8c01483f271
https://pubmed.ncbi.nlm.nih.gov/11316779

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Effects of 4 percent and 6 percent carboxyhemoglobin on arrhythmia production in patients with coronary artery disease

Autor: D S, Sheps, M C, Herbst, A L, Hinderliter, K F, Adams, L G, Ekelund, J J, O'Neil, G M, Goldstein, P A, Bromberg, M, Ballenger, S M, Davis

Publikováno v: Research report (Health Effects Institute). (41)

In this study, we assessed the effects of exposure to 4 percent and 6 percent carboxyhemoglobin on ventricular arrhythmias in 41 subjects (nonsmokers) with documented coronary artery disease. We used a randomized, double-blind, crossover design. On d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c7b052937f72b131655e4f57d11145c
https://pubmed.ncbi.nlm.nih.gov/1716916

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Can animal pulmonary function testing provide data for regulatory decision making?

Autor: J A Raub, J J O'Neil

Publikováno v: Environmental Health Perspectives

The process of setting health standards requires rigorous, scientifically sound data that relate to man's interaction with his environment. Tests of pulmonary function are especially useful, since they may permit some direct comparisons between anima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622b22175b0116448cfbffd70a0aff67
https://doi.org/10.1289/ehp.8352215

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Pulmonary injury in rats following continuous exposure to 60% O2 for 7 days

Autor: B A Freeman, J. J. O'Neil, G. Hayatdavoudi, J. D. Crapo, B. E. Barry

Publikováno v: Journal of Applied Physiology. 51:1220-1231

Morphological, biochemical, and physiological studies were done on rats exposed to 60% O2 for 7 days. This exposure did not induce O2 tolerance but instead caused a significant decrease in survival time of animals subsequently exposed to pure O2. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74513d8c398473731dba3e71064c9f45
https://doi.org/10.1152/jappl.1981.51.5.1220

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Factors determining degree of inflation in intratracheally fixed rat lungs

Autor: G. Hayatdavoudi, J. J. O'Neil, Frederick J. Miller, James D. Crapo

Publikováno v: Journal of Applied Physiology. 48:389-393

The total lung capacity (TLC) of rats was measured in vivo and was compared to the displacement volume of the lungs following intratracheal fixation with glutaraldehyde or formaldehyde solution. When glutaraldehyde was used the speed of infusion of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b5545beba2b6b776951f10fae5df8c
https://doi.org/10.1152/jappl.1980.48.2.389

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Single-breath diffusing capacity and lung volumes in small laboratory mammals

Autor: J J O'Neil, Frederick J. Miller, J Takezawa

Publikováno v: Journal of Applied Physiology. 48:1052-1059

We measured the single-breath diffusing capacity for carbon monoxide (DLCO), total lung capacity (TLC), functional residual capacity (FRC), and residual volume (RV) in anesthetized male hamsters, rats, guinea pigs, and rabbits whose weights varied fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825be141a606c3d0ed588ff045cbdab8
https://doi.org/10.1152/jappl.1980.48.6.1052

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Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice

Autor: B J Miller, M C Appel, J J O'Neil, L S Wicker

Publikováno v: The Journal of Immunology. 140:52-58

The nonobese diabetic mouse is a model of spontaneous type I diabetes mellitus. It is possible to induce diabetes in young, irradiated nonobese diabetic mice by using adoptive transfer of splenocytes or splenic T cells obtained from diabetic donors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31094cbf5339ade83681362b6c514179
https://doi.org/10.4049/jimmunol.140.1.52

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