Zobrazeno 1 - 7
of 7
pro vyhledávání: '"J J, Metterville"'
Publikováno v:
Polymeric Materials in Medication ISBN: 9781489922472
Iron chelation therapy is used to remove iron in cases of iron poisoning and Cooley’s Anemia. Cooley’s Anemia is characterized by an inability to synthesize the 3-chain of hemoglobin. Frequent transfusion, the primary treatment, introduces iron,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9097ea92e2e2531e557159866a39775a
https://doi.org/10.1007/978-1-4899-2245-8_17
https://doi.org/10.1007/978-1-4899-2245-8_17
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 232(3)
A series of polymers bearing hydroxamic acid-terminated side chains were prepared for the purpose of developing new iron chelators for treating iron overload in beta-thalassemia (Cooley's anemia) and other iron diseases. The polymers are for the most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01c93783e25912698fa01d7b982e0498
https://pubmed.ncbi.nlm.nih.gov/3973822
https://pubmed.ncbi.nlm.nih.gov/3973822
Publikováno v:
Chemischer Informationsdienst. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6826a3a464999210694acd0d3abdcbc0
https://doi.org/10.1002/chin.198648167
https://doi.org/10.1002/chin.198648167
Autor:
H, Rosenkrantz, J J, Metterville
Publikováno v:
The Journal of laboratory and clinical medicine. 95(5)
The use of EDBPHA as a potential iron chelator in cases of hemochromatosis provided impetus for investigating its toxicology. Because a reddish coloration of excreta was observed during subchronic administration of the drug to dogs, measurements of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::06cb9000952daa3e1381eaf5d8c245bc
https://pubmed.ncbi.nlm.nih.gov/7365318
https://pubmed.ncbi.nlm.nih.gov/7365318
Autor:
C G, Pitt, G, Gupta, W E, Estes, H, Rosenkrantz, J J, Metterville, A L, Crumbliss, R A, Palmer, K W, Nordquest, K A, Hardy, D R, Whitcomb, B R, Byers, J E, Arceneaux, C G, Gaines, C V, Sciortino
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 208(1)
A large-scale systematic evaluation of potential iron chelators for the treatment of hemosiderosis was conducted. The compounds were identified and evaluated using a hypertransfused mouse screen in which deferrioxamine B was a standard. This screen w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ffb9745cf191a9e5d5a877ebfc0322ff
https://pubmed.ncbi.nlm.nih.gov/759605
https://pubmed.ncbi.nlm.nih.gov/759605
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 6(2)
Because of a projected pilot study with EDHPA in Cooley's anemia patients, animal studies with emphasis on reversibility of potential toxic signs were performed. Young dogs were treated iv with 6-18 mg/kg or orally with 30-240 mg/kg for 14 days follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d9e43575c8e49895861293280735d262
https://pubmed.ncbi.nlm.nih.gov/3699319
https://pubmed.ncbi.nlm.nih.gov/3699319
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 1986 Jul; Vol. 29 (7), pp. 1231-7.