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Akademický článek

Synthesis and characterization of a new bile acid and platinum(II) complex with cytostatic activity

Autor: J J Criado, M C Herrera, M F Palomero, M Medarde, E Rodriguez, J J Marin

Publikováno v: Journal of Lipid Research, Vol 38, Iss 5, Pp 1022-1032 (1997)

With a view to using bile acids as shuttles for delivering platinum-related cytostatic drugs to the liver, a cholylglycine(CG)-derivative of platinum(II) has been synthesized. The complex, named Bamet-H2, was characterized by elemental analysis, FT-I

Externí odkaz: https://doaj.org/article/a3466c03faa74fd485cee080f83b02f9

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[Attention deficit hyperactivity disorder in preschool age children. Its epidemiological prevalence in Navarra and La Rioja, Spain]

Autor: J J, Marin-Mendez, M J, Alvarez-Gomez, M C, Borra-Ruiz, M, Vallejo-Valdivielso, A, Diez-Suarez, P, de Castro-Manglano, C, Soutullo-Esperon

Publikováno v: Revista de neurologia. 66(S01)

There are few studies about preschool attention deficit hyperactivity disorder (ADHD) prevalence.To study the prevalence of ADHD in preschoolers using an specific scale (ADHD-RS-IV-P-Es) developed for this age range.We evaluated the prevalence of pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::951faa5f26eb7da8136f0c83092f1da1
https://pubmed.ncbi.nlm.nih.gov/29516463

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Akademický článek

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Increased levels of typically fetal bile acid species in patients with hepatocellular carcinoma

Autor: M Y, El-Mir, M D, Badia, N, Luengo, M J, Monte, J J, Marin

Publikováno v: Clinical science (London, England : 1979). 100(5)

The aim of this work was to investigate the reappearance during liver neoplasia of bile acids (BAs) species, which are unusual in healthy adults, but common in fetuses. Serum and urine samples were collected from patients with hepatocellular carcinom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4e61c5c1315999c0edd258f796b77855
https://pubmed.ncbi.nlm.nih.gov/11294690

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Overcoming cisplatin resistance in vitro by a free and liposome-encapsulated bile acid derivative: BAMET-R2

Autor: O, Briz, M A, Serrano, R I, Macias, J J, Marin

Publikováno v: International journal of cancer. 88(2)

Low water solubility and development of resistance are important drawbacks in the use of cisplatin as a cytostatic agent. A novel bile acid-cisplatin complex, Bamet-R2 [cis-diamminechlorocholylglycinateplatinum (II)], with liver vectoriality, has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e28c8a6143c4db051aafa84b7405e9ec
https://pubmed.ncbi.nlm.nih.gov/11004682

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Synthesis and characterization of sodium cis-dichlorochenodeoxycholylglycinato(O,N) platinum(II)--cytostatic activity

Autor: J J, Criado, M C, Garcia-Moreno, R R, Macias, J J, Marin, M, Medarde, E, Rodriguez-Fernandez

Publikováno v: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 12(3)

With a view to using bile acids as shuttles for delivering platinum-related cytostatic drugs to liver tumors, a chenodeoxycholylglycinato(CDCG)-derivative of platinum(II) has been synthesized. The complex--named Bamet-M2--was chemically characterized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8cfb08f36ac03c7ec5338f648a678d0b
https://pubmed.ncbi.nlm.nih.gov/10581693

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DNA interaction and cytostatic activity of the new liver organotropic complex of cisplatin with glycocholic acid: Bamet-R2

Autor: J J, Marin, R I, Macias, J J, Criado, A, Bueno, M J, Monte, M A, Serrano

Publikováno v: International journal of cancer. 78(3)

The aim of this study was to investigate the ability of the new liver organotropic complex of cisplatin with glycocholate (GC), Bamet-R2, to interact with DNA, inhibit its replication and hence reduce tumor-cell proliferation. Changes in the electrop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::193044f2c9e364482e16fec59b6b79ef
https://pubmed.ncbi.nlm.nih.gov/9766570

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Bile acid secretion during synchronized rat liver regeneration

Autor: M J, Monte, M Y, El-Mir, G R, Sainz, P, Bravo, J J, Marin

Publikováno v: Biochimica et biophysica acta. 1362(1)

One major difficulty in interpreting the changes occurring during liver regeneration is the co-existence of non-activated cells and proliferating hepatocytes at all stages of differentiation. The aim of this study was to investigate bile acid (BA) se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19d4edca8de784f16c6631bc51363696
https://pubmed.ncbi.nlm.nih.gov/9434100

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Bile acid-induced modifications in DNA synthesis by the regenerating perfused rat liver

Autor: J J, Marin, E R, Barbero, M C, Herrera, A, Tabernero, M J, Monte

Publikováno v: Hepatology (Baltimore, Md.). 18(5)

Liver cell proliferation is a complex process that can be affected by a large number of factors such as bile acids, which have been reported to be associated to the pathogenesis of liver cancer. In this work, bile acid-induced modifications in DNA sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54c75c0527f88e0f4d5eb4146c190fb8
https://pubmed.ncbi.nlm.nih.gov/8225225

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