Zobrazeno 1 - 10 of 228 pro vyhledávání: '"J J, Lipsky"'
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Metabolism of a disulfiram metabolite, S-methyl N,N-diethyldithiocarbamate, by flavin monooxygenase in human renal microsomes
Autor: M G, Pike, D C, Mays, D W, Macomber, J J, Lipsky
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(2)
S-Methyl N,N-diethyldithiocarbamate (MeDDC), a metabolite of the alcohol deterrent disulfiram, is converted to MeDDC sulfine and then S-methyl N,N-diethylthiocarbamate sulfoxide, the proposed active metabolite in vivo. Several isoforms of CYP450 and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a43d24588df81c3ee283b21dd12317f1
https://pubmed.ncbi.nlm.nih.gov/11159801
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3
Clinical outcome and pharmacokinetics after addition of low-dose cyclosporine to methotrexate: a case study of five patients with treatment-resistant inflammatory bowel disease
Autor: L J, Egan, W J, Tremaine, D C, Mays, J J, Lipsky, W J, Sandborn
Publikováno v: Inflammatory bowel diseases. 6(4)
This study reports the clinical outcome, toxicity, and methotrexate pharmacokinetics after the addition of low-dose cyclosporine to methotrexate in patients with ulcerative colitis or Crohn's disease.Three patients with steroid-refractory ulcerative
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ff5a59dc926ff0e2235f99876301a88
https://pubmed.ncbi.nlm.nih.gov/11149561
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4
Identification of the protein-drug adduct formed between aldehyde dehydrogenase and S-methyl-N,N-diethylthiocarbamoyl sulfoxide by on-line proteolytic digestion high performance liquid chromatography electrospray ionization mass spectrometry
Autor: M L, Shen, K L, Johnson, D C, Mays, J J, Lipsky, S, Naylor
Publikováno v: Rapid communications in mass spectrometry : RCM. 14(10)
Disulfiram has been used clinically as an aversion therapy treatment for recovering alcoholics. One of its metabolites, S-methyl-N, N-diethylthiocarbamoyl sulfoxide (MeDTC-SO), is currently believed by some to be the active metabolite in vivo. We dem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ad44fe1b132872f548d137124ab4fe96
https://pubmed.ncbi.nlm.nih.gov/10825257
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5
A randomized dose-response and pharmacokinetic study of methotrexate for refractory inflammatory Crohn's disease and ulcerative colitis
Autor: L J, Egan, W J, Sandborn, W J, Tremaine, J A, Leighton, D C, Mays, M G, Pike, A R, Zinsmeister, J J, Lipsky
Publikováno v: Alimentary pharmacologytherapeutics. 13(12)
The optimum initial dose of methotrexate for steroid-requiring inflammatory bowel disease is not known.To compare directly the efficacy and toxicity of methotrexate 15 and 25 mg/week, and to explore the value of methotrexate blood levels as predictor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80b80aa95c4007f5d3c95f31685f7a0d
https://pubmed.ncbi.nlm.nih.gov/10594394
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6
Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease. North American Azathioprine Study Group
Autor: W J, Sandborn, W J, Tremaine, D C, Wolf, S R, Targan, C A, Sninsky, L R, Sutherland, S B, Hanauer, J W, McDonald, B G, Feagan, R N, Fedorak, K L, Isaacs, M G, Pike, D C, Mays, J J, Lipsky, S, Gordon, C S, Kleoudis, R H, Murdock
Publikováno v: Gastroenterology. 117(3)
Azathioprine is effective for Crohn's disease but acts slowly. A loading dose may decrease the time to response.A placebo-controlled study was conducted in patients with active Crohn's disease despite prednisone treatment. Patients were randomized to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3f3b5e4dd828d697f51938c794a7d6f5
https://pubmed.ncbi.nlm.nih.gov/10866522
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7
Roles of FMO and CYP450 in the metabolism in human liver microsomes of S-methyl-N,N-diethyldithiocarbamate, a disulfiram metabolite
Autor: M G, Pike, Y N, Martin, D C, Mays, L M, Benson, S, Naylor, J J, Lipsky
Publikováno v: Alcoholism, clinical and experimental research. 23(7)
The conversion of S-methyl-N,N-diethyldithiocarbamate (MeDDC) to MeDDC sulfine is the first step after methylation in the metabolic pathway of disulfiram, an alcohol deterrent, to its ultimate active metabolite. Various isoforms of CYP450 have recent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8215d2ee6f69aa4d583386cc89d38c33
https://pubmed.ncbi.nlm.nih.gov/10443982
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10
Measles antibody seroprevalence rates among immunized Inuit, Innu and Caucasian subjects
Autor: G A, Poland, R M, Jacobson, S A, Colbourne, A M, Thampy, J J, Lipsky, P C, Wollan, P, Roberts, S J, Jacobsen
Publikováno v: Vaccine. 17(11-12)
Measles antibody seroprevalence was compared in Innu, Inuit, and Caucasian peoples of northern Newfoundland, Canada, who were immunized with a single dose of M-M-R-II (Merck Research Laboratories) vaccine. Healthy, volunteer schoolchildren (n = 606)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0dadb550173f18c1604a7ac14a9e2818
https://pubmed.ncbi.nlm.nih.gov/10195789
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