Zobrazeno 1 - 10 of 19 pro vyhledávání: '"J J, Letterio"'
1
Up-regulation of cytokine mRNA, adhesion molecule proteins, and MHC class II proteins in salivary glands of TGF-beta1 knockout mice: MHC class II is a factor in the pathogenesis of TGF-beta1 knockout mice
Autor: T Nakabayashi, J J Letterio, A G Geiser, L Kong, N Ogawa, W Zhao, T Koike, G Fernandes, H Dang, N Talal
Publikováno v: The Journal of Immunology. 158:5527-5535
Mice homozygous for a disrupted TGF-beta1 allele develop multiple lymphoproliferative disorders similar to those seen in the pseudolymphoma of Sjögren's syndrome. At 2 wk of age, these TGF-beta1 mutant mice begin to develop wasting syndrome and die
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8ee1c2b2fed82ab69b0c49a2b05aefa
https://doi.org/10.4049/jimmunol.158.11.5527
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2
SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF-beta knockout mice
Autor: H Dang, A G Geiser, J J Letterio, T Nakabayashi, L Kong, G Fernandes, N Talal
Publikováno v: The Journal of Immunology. 155:3205-3212
Mice bearing the TGF-beta 1 null mutation (-/-) develop lymphoid infiltrates in the heart, lungs, salivary glands, and other organs similar to those seen in the pseudolymphoma of Sjögren's Syndrome. We studied sera from -/- mice and found elevated A
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ddbdbef738ad838fe48a59e1ef88cac
https://doi.org/10.4049/jimmunol.155.6.3205
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3
TGF-beta1 null mutation leads to CD154 upregulated expression in affected tissues
Autor: T, Nakabayashi, K M, Sakata, A, Sakata, L, Kong, C A, Lau, J J, Letterio, N, Vela-Roch, N, Talal, H, Dang
Publikováno v: Inflammation. 25(2)
The TGF-beta1(-/-) mouse is a murine model for systemic autoimmune disease. The aim of this study is to elucidate the immunological mechanism that leads to multifocal tissue inflammation and autoantibody production in TGF-beta1(-/-) mice. Heart, lung
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf705510d281b5771f00555435828b71
https://pubmed.ncbi.nlm.nih.gov/11321361
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4
Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse
Autor: S, Kobayashi, K, Yoshida, J M, Ward, J J, Letterio, G, Longenecker, L, Yaswen, B, Mittleman, E, Mozes, A B, Roberts, S, Karlsson, A B, Kulkarni
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(7)
TGF-beta 1 null (TGF-beta1-/-) mice die at 3-4 wk of age and show an autoimmune inflammatory phenotype associated with enhanced expression of both class I and II MHC molecules. To determine the role of MHC class I Ags in the autoimmune manifestations
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e33838348374cf6c65cb5a6baa2b4c4b
https://pubmed.ncbi.nlm.nih.gov/10491004
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5
Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production
Autor: R A, Seder, T, Marth, M C, Sieve, W, Strober, J J, Letterio, A B, Roberts, B, Kelsall
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 160(12)
TGF-beta has been shown to play a central role in regulating inflammatory responses; thus, understanding the factors involved in the generation of TGF-beta-producing cells could lead to interventions that are useful in effecting disease progression.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2a43818a79c77eb6e4a4436fab6abe4
https://pubmed.ncbi.nlm.nih.gov/9637480
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8
Induction of transforming growth factor beta 1 and its receptors during all-trans-retinoic acid (RA) treatment of RA-responsive human neuroblastoma cell lines
Autor: P S, Cohen, J J, Letterio, C, Gaetano, J, Chan, K, Matsumoto, M B, Sporn, C J, Thiele
Publikováno v: Cancer research. 55(11)
Recent work on a variety of normal and malignant cell lines has shown that induction and secretion of biologically active TGF-beta may occur after exposure to all-trans-retinoic acid (RA), coincident with decreased growth rate and/or differentiation.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a74dfc0d0ba28f17cd268119a970e325
https://pubmed.ncbi.nlm.nih.gov/7757990
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10
Transforming growth factor-beta1 circulates in normal human plasma and is unchanged in advanced metastatic breast cancer
Autor: L M, Wakefield, J J, Letterio, T, Chen, D, Danielpour, R S, Allison, L H, Pai, A M, Denicoff, M H, Noone, K H, Cowan, J A, O'Shaughnessy
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 1(1)
A method has been developed to determine true plasma transforming growth factor beta (TGF-beta) levels by using the platelet alpha granule-specific marker, platelet factor 4, to correct for the TGF-beta contributed by platelets degranulated ex vivo.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04f070c743f5f1cce1b7a729970902da
https://pubmed.ncbi.nlm.nih.gov/9815895
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