Zobrazeno 1 - 6 of 6 pro vyhledávání: '"J J, Leffert"'
1
A clinical-pharmacological evaluation of percutaneous isolated hepatic infusion of doxorubicin in patients with unresectable liver tumors
Autor: W J, Hwu, R R, Salem, J, Pollak, M, Rosenblatt, E, D'Andrea, J J, Leffert, S, Faraone, J C, Marsh, G, Pizzorno
Publikováno v: Oncology research. 11(11-12)
A dose escalation study of hepatic arterial infusion of doxorubicin during hemodynamic isolation of the liver (the Delcath system) was conducted to: 1) study the pharmacokinetics of regional doxorubicin therapy, and 2) define therapeutic efficacy in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21b0f2908180a34baf63559d94fda07b
https://pubmed.ncbi.nlm.nih.gov/10905565
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2
In vivo effect of 5-ethynyluracil on 5-fluorouracil metabolism determined by 19F nuclear magnetic resonance spectroscopy
Autor: E R, Adams, J J, Leffert, D J, Craig, T, Spector, G, Pizzorno
Publikováno v: Cancer research. 59(1)
Biochemical modulation of 5-fluorouracil (5-FU) has been used over the past 20 years to improve the therapeutic efficacy of this antineoplastic agent. Recently, modulation of the catabolic pathway of this fluoropyrimidine has been the focus of extens
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bbbfa31e00bfe2a7e67846f9269b69c7
https://pubmed.ncbi.nlm.nih.gov/9892196
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3
Cytosine deaminase adenoviral vector and 5-fluorocytosine selectively reduce breast cancer cells 1 million-fold when they contaminate hematopoietic cells: a potential purging method for autologous transplantation
Autor: L. H. Yin, E. G. Hanania, Albert B. Deisseroth, J. J. Leffert, J. H. Won, Ronald G. Crystal, Giuseppe Pizzorno, R. E. Giles, Richard J. Cote, Barbara Burtness, J. Liang, W. L. Wang, T. Nanakorn, X. Y. Peng, E. Adams, Matthew R. Cooperberg, Siqing Fu, R. Brown, F. Garcia-Sanchez, D. S. Krause
Publikováno v: Blood, vol 92, iss 2
Scopus-Elsevier
Garcia-Sanchez, F; Pizzorno, G; Fu, SQ; Nanakorn, T; Krause, DS; Liang, J; et al.(1998). Cytosine deaminase adenoviral vector and 5-fluorocytosine selectively reduce breast cancer cells 1 million-fold when they contaminate hematopoietic cells: A potential purging method for autologous transplantation. Blood, 92(2), 672-682. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6g53q4pc
Europe PubMed Central
Ad.CMV-CD is a replication incompetent adenoviral vector carrying a cytomegalovirus (CMV)-driven transcription unit of the cytosine deaminase (CD) gene. The CD transcription unit in this vector catalyzes the deamination of the nontoxic pro-drug, 5-fl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6388da6c2c80507a405e675624d3028
https://escholarship.org/uc/item/6g53q4pc
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4
Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor
Autor: G, Pizzorno, L, Yee, B A, Burtness, J C, Marsh, J W, Darnowski, M Y, Chu, S H, Chu, E, Chu, J J, Leffert, R E, Handschumacher, P, Calabresi
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(5)
Benzylacyclouridine (BAU, IND 039655) is a potent and specific inhibitor of uridine phosphorylase (UrdPase; EC 2.4.2.3). This enzyme plays a major role in regulating uridine homeostasis and also catalyzes the conversion of fluoropyrimidine nucleoside
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::acec260b04ef8fcbe5bd8039bb0dc6bf
https://pubmed.ncbi.nlm.nih.gov/9607574
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