Zobrazeno 1 - 10
of 58
pro vyhledávání: '"J J, HAGAN"'
Publikováno v:
Behavioural Pharmacology. 14:545-550
Gerbils are a highly social species and extremely sensitive to social manipulations. In this laboratory, separating male/female pairs has been found to produce significant effects on these animal's subsequent social behaviour. The present studies wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3bc2aef41cad108509e22148531928
https://doi.org/10.1097/00008877-200311000-00007
https://doi.org/10.1097/00008877-200311000-00007
Publikováno v:
Psychopharmacology. 138:275-282
Sabcomeline, (SB-202026 [R-(Z)-alpha-(methoxyimino)-1 -azabicyclo [2.2.2] octane-3-acetonitrile]), a functionally selective muscarinic M1 receptor partial agonist, was tested in rats trained to perform a delayed, reinforced alternation task in a T ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7260c756a65120d4ae7a20c6e735b1b4
https://doi.org/10.1007/s002130050672
https://doi.org/10.1007/s002130050672
Publikováno v:
British journal of pharmacology. 132(7)
1. The presence of 5-HT(7) receptor mRNA and protein in 5-HT neurons suggests that this receptor may act as a 5-HT autoreceptor. In this study, the effect of the 5-HT(7) receptor antagonist, SB-269970 ((R)-1-[3-hydroxy phenyl)sulfonyl]-2-[2-(4-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::730ba038499653ac637eeaccb5a80401
https://pubmed.ncbi.nlm.nih.gov/11264252
https://pubmed.ncbi.nlm.nih.gov/11264252
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 294(3)
This study examined the effect of acute and repeated p.o. administration of the selective D(3) receptor antagonist SmithKline Beecham (SB)-277011-A (1, 3, or 10 mg/kg) on the activity of spontaneously active midbrain dopamine (DA) neurons in anesthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4cb4c75683df26e6e5ee60c636b6f3fa
https://pubmed.ncbi.nlm.nih.gov/10945873
https://pubmed.ncbi.nlm.nih.gov/10945873
Autor:
C, Reavill, S G, Taylor, M D, Wood, T, Ashmeade, N E, Austin, K Y, Avenell, I, Boyfield, C L, Branch, J, Cilia, M C, Coldwell, M S, Hadley, A J, Hunter, P, Jeffrey, F, Jewitt, C N, Johnson, D N, Jones, A D, Medhurst, D N, Middlemiss, D J, Nash, G J, Riley, C, Routledge, G, Stemp, K M, Thewlis, B, Trail, A K, Vong, J J, Hagan
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 294(3)
SB-277011-A (trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolininecarboxamide), is a brain-penetrant, high-affinity, and selective dopamine D(3) receptor antagonist. Radioligand-binding experiments in Chinese hams
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08a1378e0dba35339782ae1689d10d0e
https://pubmed.ncbi.nlm.nih.gov/10945872
https://pubmed.ncbi.nlm.nih.gov/10945872
Autor:
J J, Hagan, G W, Price, P, Jeffrey, N J, Deeks, T, Stean, D, Piper, M I, Smith, N, Upton, A D, Medhurst, D N, Middlemiss, G J, Riley, P J, Lovell, S M, Bromidge, D R, Thomas
Publikováno v:
British journal of pharmacology. 130(3)
The novel 5-HT(7) receptor antagonist, SB-269970-A, potently displaced [(3)H]-5-CT from human 5-HT(7(a)) (pK(i) 8.9+/-0.1) and 5-HT(7) receptors in guinea-pig cortex (pK(i) 8.3+/-0.2). 5-CT stimulated adenylyl cyclase activity in 5-HT(7(a))/HEK293 me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2fba9af73cfc119fddf16ee0f070d70
https://pubmed.ncbi.nlm.nih.gov/10821781
https://pubmed.ncbi.nlm.nih.gov/10821781
Autor:
D R, Thomas, P J, Atkinson, M, Ho, S M, Bromidge, P J, Lovell, A J, Villani, J J, Hagan, D N, Middlemiss, G W, Price
Publikováno v:
British journal of pharmacology. 130(2)
Binding of the 5-HT(7) receptor antagonist radioligand [(3)H]-SB-269970 to human 5-HT(7(a)) receptors expressed in HEK293 cell membranes (h5-HT(7(a))/293) and to guinea-pig cerebral cortex membranes, was characterized and compared with [(3)H]-5-CT bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb9bed005eacd21675947e60545ca6bf
https://pubmed.ncbi.nlm.nih.gov/10807680
https://pubmed.ncbi.nlm.nih.gov/10807680
Publikováno v:
British journal of pharmacology. 127(7)
1. The aim of the present study was to characterize functional responses to ropinirole, its major metabolites in man (SKF-104557 (4-[2-(propylamino)ethyl]-2-(3H) indolone), SKF-97930 (4-carboxy-2-(3H) indolone)) and other dopamine receptor agonists a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67e9527fa64319a6301d5bb98128a69e
https://pubmed.ncbi.nlm.nih.gov/10455328
https://pubmed.ncbi.nlm.nih.gov/10455328
Autor:
P. D. Slade, P. Ham, K. R. Mulholland, Gary W. Price, J. J. Hagan, J V Selkirk, Graham Francis Joiner, Laramie Mary Gaster, F. D. King, Wyman Paul Adrian, Derek N. Middlemiss, Carol Routledge, Claire Roberts
Publikováno v:
Annals of the New York Academy of Sciences. 861
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2d2585a1e29aa29aca6473b498d272
https://pubmed.ncbi.nlm.nih.gov/9928285
https://pubmed.ncbi.nlm.nih.gov/9928285
Autor:
J P Hatcher, J J Hagan
Publikováno v:
Psychopharmacology. 140(4)
The effects of the dopamine D3/D2 receptor agonists quinpirole, quinelorane and (+/-)7-OH-DPAT [(+/-) 7-hydroxy-2(N,N-di-n-propylamino) tetralin] on intracranial self-stimulation (ICSS) were investigated. Rats implanted with bipolar electrodes into t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c83537b8cba1fbef2d09202eecb859
https://pubmed.ncbi.nlm.nih.gov/9888614
https://pubmed.ncbi.nlm.nih.gov/9888614