Zobrazeno 1 - 10
of 85
pro vyhledávání: '"J J, Goronzy"'
Publikováno v:
Journal of Clinical Investigation. 94:1134-1140
Macrophages represent a critical component in the inflammatory lesions of giant cell arteritis. By combining immunohistochemistry and in situ hybridization, we have analyzed the functional heterogeneity of tissue-infiltrating macrophages in patients
Publikováno v:
The Journal of Immunology. 151:825-836
We have studied the molecular diversity of the allogeneic TCR repertoire specific for the HLA-DR4 variant, DRB1*0404, by analyzing the V beta gene segment usage of CD4+ T cell clones from nine different donors and comparing the V beta repertoire in a
Publikováno v:
The Journal of Immunology. 148:604-611
Superantigens encoded in the genome or released by bacteria have been identified as potent modulators of the murine immune system. High frequencies of mature or immature T cells are activated or intrathymically deleted when superantigens cross-link M
Publikováno v:
Autoimmunity. 42(7)
Immune-mediated damage to medium-sized arteries results in wall remodeling with intimal hyperplasia, luminal stenosis and tissue ischemia. In the case of the aorta, vasculitis may result in dissection, aneurysm or rupture. The response-to-injury prog
Publikováno v:
Expert opinion on biological therapy. 9(8)
Current treatments for autoimmune disease are hampered by the non-specificity of immunomodulatory interventions, having to accept broad suppression of immunoresponsiveness with potential serious side effects, such as infection or malignancy. The deve
Autor:
C M, Weyand, J J, Goronzy
Publikováno v:
Zeitschrift fur Rheumatologie. 68(2)
Giant cell arteritis (GCA), is a systemic vasculitis which preferentially targets large and medium branches of the upper-body aorta. Typical clinical manifestations result from arterial stenosis/occlusion causing blindness, stroke and aortic arch syn
Publikováno v:
The Journal of Immunology. 147:70-78
The self-restriction of Ag-specific T cell responses is interpreted as the result of a positive selection of the individual's T cell specificities for their compatibility with self-MHC molecules. If the T cell receptor (TCR) specificities in any give
Autor:
Konstantinos Aznaouridis, Sarfraz Ali, Nino Kavtaradze, Ibhar Al Mheid, Farah Quyyumi, Muhiddin Ozkor, Saurabh Dhawan, Jonathan Murrow, Riyaz Patel, Connie Weyand, J J Goronzy, R W Alexander, Arshed Quyyumi
Publikováno v:
Circulation. 118
Background: Physical activity is a determinant of cardiovascular performance and a predictor of risk. Levels of progenitor cells that contribute to repair of tissues including the cardiovascular system are modulated by cardiovascular risk factors and
Publikováno v:
Current directions in autoimmunity. 3
Autor:
J J, Goronzy, C M, Weyand
Publikováno v:
Current directions in autoimmunity. 3