Výsledky vyhledávání - "J J, De Pont"

Binding of ethylenediamine to phosphatidylserine is inhibitory to Na+/K+-ATPase

Autor: F M, Schuurmans Stekhoven, G I, Tesser, G, Ramsteyn, H G, Swarts, J J, De Pont

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1109:17-32

Covalent linkage of ethylenediamine with the Na + /K + -ATPase complex from rabbit kidney outer medulla by the use of the water-soluble carbodiimide, N -ethyl, N ′-(3-dimethylaminopropyl)carbodiimide, resulted in a 73% reaction with phosphatidylser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdf9a0be1be58e4d8075d10629037de
https://doi.org/10.1016/0005-2736(92)90182-l

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K(+)-independent gastric H(+),K(+)-atpase activity. Dissociation of K(+)-independent dephosphorylation and preference for the E1 conformation by combined mutagenesis of transmembrane glutamate residues

Autor: H G, Swarts, J B, Koenderink, H P, Hermsen, P H, Willems, J J, De Pont

Publikováno v: The Journal of biological chemistry. 276(40)

Several mutations of residues Glu(795) and Glu(820) present in M5 and M6 of the catalytic subunit of gastric H(+),K(+)-ATPase have resulted in a K(+)-independent, SCH 28080-sensitive ATPase activity, caused by a high spontaneous dephosphorylation rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ee3dfc83f54519bb98ff4d0195a512c
https://pubmed.ncbi.nlm.nih.gov/11470785

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Chimeras of X+, K+-ATPases. The M1-M6 region of Na+, K+-ATPase is required for Na+-activated ATPase activity, whereas the M7-M10 region of H+, K+-ATPase is involved in K+ de-occlusion

Autor: J B, Koenderink, H G, Swarts, H C, Stronks, H P, Hermsen, P H, Willems, J J, De Pont

Publikováno v: The Journal of biological chemistry. 276(15)

In this study we reveal regions of Na(+),K(+)-ATPase and H(+),K(+)-ATPase that are involved in cation selectivity. A chimeric enzyme in which transmembrane hairpin M5-M6 of H(+),K(+)-ATPase was replaced by that of Na(+),K(+)-ATPase was phosphorylated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c7744f65ece2925c1ca5e9e4060d859
https://pubmed.ncbi.nlm.nih.gov/11278751

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Dominant isolated renal magnesium loss is caused by misrouting of the Na(+),K(+)-ATPase gamma-subunit

Autor: L.P.W.J. van den Heuvel, J J de Pont, Jan B. Koenderink, Leo A. H. Monnens, H Van Bokhoven, K.F.H. Assink, Iwan C. Meij, René J. M. Bindels, Nine V A M Knoers, Wouter M. Tiel Groenestege

Publikováno v: Nature Genetics, 26, 265-266
Nature Genetics, 26, pp. 265-266

Primary hypomagnesaemia is composed of a heterogeneous group of disorders characterized by renal or intestinal Mg(2+) wasting, often associated with disturbances in Ca(2+) excretion. We identified a putative dominant-negative mutation in the gene enc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbcc625136b0911fb54e9abedfcc387
https://pubmed.ncbi.nlm.nih.gov/11062458

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Mutational analysis of the potential phosphorylation sites for protein kinase C on the CCK(A) receptor

Autor: R L, Smeets, M A, Fouraux, W, Pouwels, S E, van Emst-de Vries, E, Ronken, J J, De Pont, P H, Willems

Publikováno v: British journal of pharmacology. 124(5)

1. Many G protein-coupled receptors contain potential phosphorylation sites for protein kinase C (PKC), the exact role of which is poorly understood. In the present study, a mutant cholecystokininA (CCK(A)) receptor was generated in which the four co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2a167fd93dcedd03be5048037a18c1c
https://pubmed.ncbi.nlm.nih.gov/9692779

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Relevance of erythrocyte Na+/Li+ countertransport measurement in essential hypertension, hyperlipidaemia and diabetic nephropathy: a critical review

Autor: K, Van Norren, T, Thien, J H, Berden, L D, Elving, J J, De Pont

Publikováno v: European journal of clinical investigation. 28(5)

In this review the usefulness of the measurement of erythrocyte Na+/Li+ countertransport (Na+/Li+ CT) activity is evaluated. In particular, the association between enhanced erythrocyte Na+/Li+ CT activity and essential hypertension, hyperlipidaemia a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5c99a8b46bef56970b4058dc01f4e1e
https://pubmed.ncbi.nlm.nih.gov/9650006

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Protein kinase C-mediated inhibition of transmembrane signalling through CCK(A) and CCK(B) receptors

Autor: R L, Smeets, M A, Fouraux, S E, van Emst-de Vries, J J, De Pont, P H, Willems

Publikováno v: British journal of pharmacology. 123(6)

1. The rat CCK(A) and CCK(B) receptors were stably expressed in Chinese hamster ovary (CHO-09) cells in order to compare modes of signal transduction and effects of protein kinase C (PKC) thereupon. 2. Spectrofluorophotometry of Fura-2-loaded cells r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::916c7eda9791126309596061987948dd
https://pubmed.ncbi.nlm.nih.gov/9559904

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Evaluation of the trophic effect of longterm treatment with the histamine H2 receptor antagonist loxtidine on rat oxyntic mucosa by differential counting of dispersed cells

Autor: J J de Pont, Corné H. W. Klaassen, Eiliv Brenna, Helge L. Waldum, Herman G.P. Swarts

Publikováno v: Gut. 35(11)

To evaluate whether the general trophic effect of gastrin on the oxyntic mucosa is an indirect effect mediated by histamine H2 receptors, sustained 24 hour hypergastrinaemia was induced in Sprague-Dawley rats by treatment with the long acting and pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3ff51d30ac9bb06a99e50939cf4104
https://pubmed.ncbi.nlm.nih.gov/7828970

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Heterogeneity between intracellular Ca2+ stores as the underlying principle of quantal Ca2+ release by inositol 1,4,5-trisphosphate in permeabilized pancreatic acinar cells

Autor: F H, van de Put, J J, De Pont, P H, Willems

Publikováno v: The Journal of biological chemistry. 269(17)

Permeabilized rabbit pancreatic acinar cells were used to study the effects of Ca2+ pump inhibition and Ca2+ store depletion on the sensitivity of internal Ca2+ stores to emptying by inositol 1,4,5-trisphosphate (Ins-1,4,5-P3). Complete inhibition of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::626fed5619a7ddfb52d37333c756b236
https://pubmed.ncbi.nlm.nih.gov/7513688

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Canavan disease: neuromorphological and biochemical analysis of a brain biopsy specimen

Autor: I F, de Coo, F J, Gabreëls, W O, Renier, J J, de Pont, U J, van Haelst, J H, Veerkamp, J M, Trijbels, H H, Jaspar, K, Renkawek

Publikováno v: Clinical neuropathology. 10(2)

In this study we present a patient with Canavan disease or Van Bogaert and Bertrand type of spongiform leukodystrophy, proven by brain biopsy. We performed morphological studies and biochemical assays on fresh homogenates of the grey and white matter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::382d381b3779cc6283fee030ccdc15e0
https://pubmed.ncbi.nlm.nih.gov/2054980

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