Zobrazeno 1 - 10
of 56
pro vyhledávání: '"J J, Cazzulo"'
Publikováno v:
Cellular microbiology. 17(10)
SUMOylation is an important post-translational modification conserved in eukaryotic organisms. In Trypanosoma brucei, SUMO (Small Ubiquitin-like MOdifier) is essential in procyclic and bloodstream forms. Furthermore, SUMO has been linked to the antig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d389173aeb7add0ff2320ca609108cfc
https://pubmed.ncbi.nlm.nih.gov/26096196
https://pubmed.ncbi.nlm.nih.gov/26096196
Publikováno v:
The Journal of Cell Biology
It has been proposed that the UDP-Glc:glycoprotein glucosyltransferase, an endoplasmic reticulum enzyme that only glucosylates improperly folded glycoproteins forming protein-linked Glc1Man7-9-GlcNAc2 from the corresponding unglucosylated species, pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee66d8fcc9157294b2ba917912b3513
https://doi.org/10.1083/jcb.130.4.771
https://doi.org/10.1083/jcb.130.4.771
Publikováno v:
FEMS Microbiology Letters. 124:191-194
Antisera raised against papain and cysteine proteinases (CPs) purified from Leishmania mexicana and Trypanosoma cruzi have been used to study the proteins in the two parasites. The antisera against the major CP of T. cruzi (cruzipain) not only cross-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74c6184b94e3120d63d0aaf124d26caf
https://doi.org/10.1111/j.1574-6968.1994.tb07283.x
https://doi.org/10.1111/j.1574-6968.1994.tb07283.x
Autor:
J. J. Cazzulo, Berta M. Franke de Cazzulo, Graham H. Coombs, Javier Martínez, Michael J. North
Publikováno v:
FEMS Microbiology Letters. 124:81-86
Three proteinase inhibitors, one peptidyl acyloxymethyl ketone (AMK), Z-Phe-Lys-CH2-OCO-(2,4,6-Me3)Ph.HCl, and two diazomethyl ketones (DMKs), Z-Phe-Phe-DMK and Z-Phe-Ala-DMK, have been studied for their effects in vitro on the four developmental sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493f098a0aee41d7366565d29e72bd2b
https://doi.org/10.1111/j.1574-6968.1994.tb07265.x
https://doi.org/10.1111/j.1574-6968.1994.tb07265.x
Publikováno v:
Scandinavian Journal of Immunology. 40:389-394
In the present study we describe the production and characterization of a panel of monoclonal antibodies (MoAbs) directed against cruzipain (Crz), the major cysteine proteinase from Trypanosoma cruzi. The five MoAbs, BD6, BF2, CG2, CH8, and DC10 were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1dbd05f219891910e058c2c9967265
https://doi.org/10.1111/j.1365-3083.1994.tb03479.x
https://doi.org/10.1111/j.1365-3083.1994.tb03479.x
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1037:186-191
A cysteine proteinase, purified to homogeneity from epimastigotes of Trypanosoma cruzi, was strongly inhibited by L-trans-epoxysuccinylleucylamido(4-guanidino)butane (E-64). The second-order rate constant was 20,800 M-1.s-1, and the reagent could be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee49526ed7d65343d820dda940f5dcff
https://doi.org/10.1016/0167-4838(90)90166-d
https://doi.org/10.1016/0167-4838(90)90166-d
Publikováno v:
Molecular and biochemical parasitology. 105(2)
Two malate dehydrogenase isoforms, named MDH1 and MDH2, have been purified to homogeneity from Trypanosoma cruzi epimastigotes. Both enzymes consist of subunits with a molecular mass close to 33 kDa; native molecular mass determination by gel filtrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9ad2bffcb31e2b16c834ddd4ae40a03a
https://pubmed.ncbi.nlm.nih.gov/10693743
https://pubmed.ncbi.nlm.nih.gov/10693743
Autor:
J J, Cazzulo
Publikováno v:
Medicina. 59
Cruzipain is the major cysteine proteinase present in Trypanosoma cruzi, the parasite causing the American Trypanosomiasis, Chagas disease. The enzyme is encoded by a high number of genes (up to 130 in the Tul 2 stock) placed in head-to-tail tandems,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dacd71c85abb266b0ee26b018924e497
https://pubmed.ncbi.nlm.nih.gov/10668237
https://pubmed.ncbi.nlm.nih.gov/10668237
Publikováno v:
European journal of biochemistry. 267(3)
A single form of serine hydroxymethyltransferase (SHMT) was detected in epimastigotes of Trypanosoma cruzi, in contrast to the three isoforms of the enzyme characterized from another trypanosomatid, Crithidia fasciculata [Capelluto D.G.S., Hellman U.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71a71de14e55cf5def246a3426efb8b2
https://pubmed.ncbi.nlm.nih.gov/10651807
https://pubmed.ncbi.nlm.nih.gov/10651807
Publikováno v:
Medicina. 58(4)
SKF525A, an inhibitor and inducer of cytochrome P450, was tested on different developmental stages of Trypanosoma cruzi. Growth, motility and structure of epimastigotes, motility and infectivity of trypomastigotes, and infectivity of trypomastigotes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8588b2013185cef7964f24315e145a89
https://pubmed.ncbi.nlm.nih.gov/9816705
https://pubmed.ncbi.nlm.nih.gov/9816705