Zobrazeno 1 - 10
of 158
pro vyhledávání: '"J J, Bergan"'
Autor:
J. J. Bergan, Zachary Rattner
Publikováno v:
Acta Chirurgica Belgica. 105:12-15
Publikováno v:
Tetrahedron: Asymmetry. 8:161-168
An efficient, 9-step synthesis of LTD 4 antagonist L-708,738 is described. The asymmetric center is set via a chiral borane reduction.
Publikováno v:
Tetrahedron Letters. 36:9445-9448
A practical, convergent synthesis of L-692,429 (1) from three key intermediates - the 3- aminobenzlactam 2, the β-lactam 3 and the biphenyltetrazole 4 is described. The mechanism of the coupling reaction in which 3 is used as a β-aminoacid equivale
Autor:
L D Hillis, J T Shepherd, J J Bergan, Barry T. Katzen, J P Mohr, Jacek Hawiger, Richard A. Cohen
Publikováno v:
Circulation. 89:532-535
Autor:
J. J. Bergan
Publikováno v:
Cardiovascular Surgery. 1:624-631
Autor:
J. J. Bergan, George B. Smith, David L. Hughes, Edward J. J. Grabowski, Zhiguo Jake Song, Gabe Dezeny, Paul J. Reider
Publikováno v:
Tetrahedron: Asymmetry. 4:865-874
Enzymatic asymmetrization of a prochiral diester having 4 bonds between the ester group and prochiral center is the cornerstone of a short and efficient synthesis of an LTD4 antagonist. The enzymatic hydrolysis occurs in a heterogeneous slurry, but a
Autor:
K. Price, C. Marcin, James M. McNamara, J. J. Bergan, N. Grinberg, J. King, M. Bhupathy, Randolph Greasham, Michel Chartrain, L. Zitano, Katz Lorraine G
Publikováno v:
Journal of Industrial Microbiology. 11:89-94
A search was implemented for a microbial lipase capable of bioconverting a diester (dimethyl 5-(3-(2-(7-chloroquinolin-2-yl)ethyl)phenyl)4,6-dithianon to its S-ester acid, an intermediate in the production of Verlukast (a leukotriene receptor antagon
Autor:
J. S. Amato, M. Bhupathy, J. L. Leazer, J. J. Bergan, David L. Hughes, Daniel R. Sidler, Paul J. Reider, Edward J. J. Grabowski, James M. McNamara
Publikováno v:
ChemInform. 22
Autor:
James M. McNamara, Paul J. Reider, David L. Hughes, Robert A. Reamer, Edward J. J. Grabowski, J. L. Leazer, Ichiro Shinkai, J. J. Bergan, T. C. Lovelace, J. S. Amato, M. Bhupathy, Daniel R. Sidler
Publikováno v:
ChemInform. 24
A practical, chemoenzymatic, four-step synthesis of the LTD4 antagonist MK-0679 is described. The key steps are enzymatic hydrolysis of the prochiral diester to the ester-acid in 99% enantiomeric excess followed by aluminum mediated amidation of the
Autor:
J. J. Bergan, Zhiguo Jake Song, George B. Smith, David L. Hughes, Edward J. J. Grabowski, Paul J. Reider, Gabe Dezeny
Publikováno v:
ChemInform. 24
Enzymatic asymmetrization of a prochiral diester having 4 bonds between the ester group and prochiral center is the cornerstone of a short and efficient synthesis of an LTD4 antagonist. The enzymatic hydrolysis occurs in a heterogeneous slurry, but a