Zobrazeno 1 - 10
of 20
pro vyhledávání: '"J J, Baldassare"'
Autor:
D M, Raben, J J, Baldassare
Publikováno v:
European Journal of Histochemistry, Vol 44, Iss 1, Pp 67-80 (2009)
Since the early 1980’s, there has been an explosion of research in an area often described as “signal transduction”. Loosely defined, signal transduction refers to the communication of a signal initiated by an extracellular agonist to the cell
Autor:
Q Y Zhang, C Hammerberg, J J Baldassare, P A Henderson, D Burns, M Ceska, J J Voorhees, G J Fisher
Publikováno v:
The Journal of Immunology. 149:1402-1408
Phorbol ester (TPA) and retinoic acid (RA) are two potent immunomodulatory agents whose actions are mediated through distinct signal transduction pathways involving protein kinase C (PKC) and nuclear RA receptors, respectively. We have investigated t
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(9)
Several reports have shown that bicyclic imidazoles, specific inhibitors of the p38 mitogen-activated protein kinase (MAPK), block cytokine synthesis at the translational level. In this study, we examined the role of p38 MAPK in the regulation of the
Publikováno v:
The Biochemical journal. 337
Addition of alpha-thrombin to quiescent IIC9 cells results in the activation of lipid-metabolizing enzymes associated with signal-transduction cascades. These enzymes include phosphatidylinositol (PI)-specific phospholipase C (PI-PLC), phosphatidylch
Publikováno v:
Journal of neuroscience research. 54(3)
Huntington's disease (HD) is a progressive neurodegenerative disease striking principally medium spiny GABAergic neurons of the caudate nucleus of the basal ganglia. It affects about one in 10,000 individuals and is transmitted in an autosomal domina
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 285(3)
Administration of exogenous sulfidopeptide leukotrienes (LTs) is associated with enhanced microvascular permeability. In addition, endogenous LTs have been implicated as participants in permeability (nonhydrostatic) edema formation. The source of LTs
Publikováno v:
The Journal of biological chemistry. 272(52)
Platelet-derived growth factor (PDGF)-induced Ras activation is required for G1 progression in Chinese hamster embryo fibroblasts (IIC9 cells). Ras stimulates both extracellular signal-related kinase (ERK) activation and RhoA activation in response t
Publikováno v:
The Journal of maternal-fetal medicine. 5(4)
The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1 alpha) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells. Prostaglandins (
Publikováno v:
The Journal of biological chemistry. 267(22)
Human platelets were found by immunoblot analysis to express protein kinase C (PKC) isozymes alpha, beta, delta, and zeta, but not gamma, epsilon, or eta. Exposure of platelets to thrombin, in the presence of 1 mM calcium, induced increased membrane
Publikováno v:
The Journal of biological chemistry. 266(13)
A 400-kDa transforming growth factor beta (TGF-beta) receptor was purified from plasma membranes of bovine liver using Triton X-100 extraction, wheat germ lectin-Sepharose 4B affinity chromatography, DEAE-cellulose anion exchange chromatography, and