Zobrazeno 1 - 10
of 155
pro vyhledávání: '"J Ian Mason"'
Autor:
Christopher R Harlow, Xuan Wu, Marielle van Deemter, Fiona Gardiner, Craig Poland, Rebecca Green, Sana Sarvi, Pamela Brown, Karl E Kadler, Yinhui Lu, J Ian Mason, Hilary O D Critchley, Stephen G Hillier
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183013 (2017)
Abdominal surgery and disease cause persistent abdominal adhesions, pelvic pain, infertility and occasionally, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposition is a consistent
Externí odkaz:
https://doaj.org/article/e05ed63c7a5b49d6b351fb6517bf7a40
Autor:
Laura Milne, Rod T. Mitchell, Lee B. Smith, Anne Jørgensen, Sarah Smith, Hanne Frederiksen, Anne-Louise Gannon, J. Ian Mason, Laura O’Hara
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Gannon, A, O’hara, L, Mason, J I, Jørgensen, A, Frederiksen, H, Milne, L, Smith, S, Mitchell, R T & Smith, L B 2019, ' Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing ', Scientific Reports, vol. 9, no. 1 . https://doi.org/10.1038/s41598-019-46049-3
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Gannon, A, O’hara, L, Mason, J I, Jørgensen, A, Frederiksen, H, Milne, L, Smith, S, Mitchell, R T & Smith, L B 2019, ' Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing ', Scientific Reports, vol. 9, no. 1 . https://doi.org/10.1038/s41598-019-46049-3
Androgens are known to be an essential regulator of male health. Androgen receptor (AR) is widely expressed throughout the adrenal cortex, yet the wider role for androgen signalling in the adrenal remains underexplored. To investigate AR-dependent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c694804b0a2d8ba9efc0c3616f67c5b0
https://doi.org/10.1038/s41598-019-46049-3
https://doi.org/10.1038/s41598-019-46049-3
Autor:
Anne Jørgensen, Adriana Traveres, Hanne Frederiksen, Lee B. Smith, Anne-Louise Gannon, Carlos J. Alcaide-Corral, Sarah Smith, Rod T. Mitchell, J. Ian Mason, Diane Rebourcet, Laura O’Hara, Laura Milne
Publikováno v:
Gannon, A, O'Hara, L, Mason, I, Rebourcet, D, Smith, S, Tavares, A, Corral, C A, Frederiksen, H, Jorgensen, A, Mitchell, R T & Smith, L B 2019, ' Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders ', Scientific Reports, vol. 9, 3250 . https://doi.org/10.1038/s41598-019-39867-y
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
The hypothalamic-pituitary-adrenal (HPA) axis regulates responses to internal and external stressors. Many patients diagnosed with conditions such as depression or anxiety also have hyperactivity of the HPA axis. Hyper-stimulation of the HPA axis res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff0de89f23c9d36c27a80e14c4d8513
https://hdl.handle.net/20.500.11820/0b8861b2-8ae0-46af-9e01-8f970194f193
https://hdl.handle.net/20.500.11820/0b8861b2-8ae0-46af-9e01-8f970194f193
Autor:
Christopher R, Harlow, Xuan, Wu, Marielle, van Deemter, Fiona, Gardiner, Craig, Poland, Rebecca, Green, Sana, Sarvi, Pamela, Brown, Karl E, Kadler, Yinhui, Lu, J Ian, Mason, Hilary O D, Critchley, Stephen G, Hillier
Publikováno v:
Harlow, C R, Wu, X, Van Deemter, M, Gardiner, F, Poland, C A, Green, R, Sarvi, S, Brown, P, Kadler, K E, Lu, Y, Mason, J I, Critchley, H O D & Hillier, S G 2017, ' Targeting lysyl oxidase reduces peritoneal fibrosis ', PLoS ONE, vol. 12, no. 8, e0183013 . https://doi.org/10.1371/journal.pone.0183013
Harlow, C R, Wu, X, van Deemter, M, Gardiner, F, Poland, C, Green, R, Sarvi, S, Brown, P, Kadler, K E, Lu, Y, Mason, J I, Critchley, H O D & Hillier, S G 2017, ' Targeting lysyl oxidase reduces peritoneal fibrosis ', PLoS ONE, vol. 12, no. 8, pp. e0183013 . https://doi.org/10.1371/journal.pone.0183013
PLoS ONE, Vol 12, Iss 8, p e0183013 (2017)
PLoS ONE
Harlow, C R, Wu, X, van Deemter, M, Gardiner, F, Poland, C, Green, R, Sarvi, S, Brown, P, Kadler, K E, Lu, Y, Mason, J I, Critchley, H O D & Hillier, S G 2017, ' Targeting lysyl oxidase reduces peritoneal fibrosis ', PLoS ONE, vol. 12, no. 8, pp. e0183013 . https://doi.org/10.1371/journal.pone.0183013
PLoS ONE, Vol 12, Iss 8, p e0183013 (2017)
PLoS ONE
BACKGROUND: Abdominal surgery and disease cause persistent abdominal adhesions, pelvic pain, infertility and occasionally, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposition is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::65b012772ca93edc8e882f2f88b7e069
https://www.research.manchester.ac.uk/portal/en/publications/targeting-lysyl-oxidase-reduces-peritoneal-fibrosis(ddb4e554-a842-4440-b6d8-9d04c0f6db0f).html
https://www.research.manchester.ac.uk/portal/en/publications/targeting-lysyl-oxidase-reduces-peritoneal-fibrosis(ddb4e554-a842-4440-b6d8-9d04c0f6db0f).html
Autor:
A. Michael Wallace, Thorsten M. Hoffmann, Dairena Gaffney, A. Forbes Howie, Malcolm Donaldson, Anwar M. El. Bakkush, J. Ian Mason
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 123:109-114
The study subject was a 13 day-old boy admitted to hospital, with weight loss since birth. He presented with the vomiting and hypotension that are classical features of congenital adrenal hyperplasia (CAH). The most common type of CAH is an autosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f67cbf2ae21ad3eb3b682aacdb13e1
https://doi.org/10.1016/j.jsbmb.2010.11.013
https://doi.org/10.1016/j.jsbmb.2010.11.013
Publikováno v:
Endocrine Reviews. 30:883-925
Masculinization depends on adequate production of testosterone by the fetal testis within a specific "masculinization programming window." Disorders resulting from subtle deficiencies in this process are common in humans, and environmental exposures/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb91e9d0a3c484b5d62c7b264af2e01
https://doi.org/10.1210/er.2009-0016
https://doi.org/10.1210/er.2009-0016
Autor:
Deborah Price, Brian R. Walker, Mick T Rae, J. Ian Mason, Stephen G. Hillier, Amirah Mohamad, Hilary O. D. Critchley, Patrick W. F. Hadoke
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 94:1443-1450
Heavy menstrual bleeding (HMB; menorrhagia) impairs quality of life for women and requires medication or surgery. Because glucocorticoids inhibit angiogenesis in other organs, we hypothesized that endometrium of women with HMB is subject to decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622dc9665a47fea79c51b7fc183348ab
https://doi.org/10.1210/jc.2008-1879
https://doi.org/10.1210/jc.2008-1879
Autor:
Richard J. Edmondson, Stephen G. Hillier, J. Ian Mason, Georgia Papacleovoulou, Hilary O. D. Critchley
Publikováno v:
Molecular and Cellular Endocrinology. 301:65-73
Ovulation-associated inflammation with accompanied cytokines and reproductive hormones impact upon the human ovarian surface epithelium (hOSE) and probably have a role in the aetiology of ovarian cancer. Progesterone and progestin-related events, i.e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca12e50dd90c2476e20a9e273e7e258
https://doi.org/10.1016/j.mce.2008.08.010
https://doi.org/10.1016/j.mce.2008.08.010
Autor:
J. Ian Mason, Margaret M. Hinshelwood, Karla J Saner-Amigh, William E. Rainey, Bruce R. Carr, Yasuhiro Nakamura, Yewei Xing
Publikováno v:
Xing, Y, Saner-Amigh, K, Nakamura, Y, Hinshelwood, M M, Carr, B R, Mason, J I & Rainey, W E 2009, ' The farnesoid X receptor regulates transcription of 3 beta-hydroxysteroid dehydrogenase type 2 in human adrenal cells ', Molecular and Cellular Endocrinology, vol. 299, no. 2, pp. 153-162 . https://doi.org/10.1016/j.mce.2008.11.006
Recent studies have shown that the adrenal cortex expresses high levels of farnesoid X receptor (FXR), but its function remains unknown. Herein, using microarray technology, we tried to identify candidate FXR targeting genes in the adrenal glands. an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b260d4ba6daa55ca9bc1556647b08c
https://doi.org/10.1016/j.mce.2008.11.006
https://doi.org/10.1016/j.mce.2008.11.006
Autor:
Matt Jobling, I. Kim Mahood, Marion F Walker, Richard M. Sharpe, Chris McKinnell, J. Ian Mason, Hayley M. Scott, Gary R. Hutchison
Publikováno v:
International Journal of Andrology. 31:103-111
A testicular dysgenesis-like syndrome is induced in rats by fetal exposure to di(n-butyl) phthalate (DBP). A key feature of this is the formation of focal dysgenetic areas comprising malformed seminiferous cords/tubules and intratubular Leydig cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a1fb11dd71b384509d9c3761bf3705
https://doi.org/10.1111/j.1365-2605.2007.00816.x
https://doi.org/10.1111/j.1365-2605.2007.00816.x